A spacer device for the oral administration of a volatile medium containing a medicament comprises a chamber ( 110 ) having an inlet ( 102 ) to admit a measured dose of medicament and an outlet ( 104 ) to be received in the mouth, wherein the spacer comprises a butterfly valve ( 106 ). Preferably, the chamber comprises two frustoconical members assembled together coaxially at their divergent ends,...

A compound of formula I wherein X, Y, X' & Y' are selected from hydrogen, halogen, substituted or unsubstituted alkyl (linear, branched or cyclo), aryl, alkyloxy and haloalkyl group; R₁, R₂, R₃ & R₄ are selected from hydrogen, substituted or unsubstituted alkyl groups (linear, branched or cyclo), aryl, heteroaryl groups or aralkyl groups, heterocycles co...

Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using suc...

An exhaust gas sensor device for detecting a concentration of at least one exhaust gas component in the exhaust gas line of an internal combustion engine is described, having at least one ChemFET for detecting the oxygen content of the exhaust gas. In addition, a corresponding engine control device and an engine control method are described.

Packaging for consumer goods having a discontinuous tactile coating is provided. The discontinuous tactile coating is formed by applying one or more varnishes to the outer surface of the packaging in a pattern comprising a plurality of raised features having a height of at least about 10 microns and a separation of at least about 20 microns. The one or more varnishes can include one or more tinted...

The present invention relates to a household appliance (1) comprising an electronic control unit (4). The electronic control unit (4) comprises a printed circuit board (40) and a microcontroller (41). An edge (43) of the board (40) comprises at least one metallized portion (44) operationally connected to the microcontroller (41). The invention also relates to a system and a method for testing or v...

Stable aqueous herbicide concentrate composition containing potassium, ammonium or isopropylamine salts of glyphosate and anionic esters of alkyl polyglycosides containing a salified sulfonic acid group.

A method for mutually blocking edges of elements of an item, in particular footwear, clothing and/or furniture items, comprising: frontal longitudinal cutting of edges (B1, B2) of a first and a second element (1, 2) of an item, to define respectively a first and a second flap (10 - 20, 11 - 21) in each of the edges (B1, B2); bringing together outer surfaces of the first flaps (10, 20) of the first...

The sewing machine M is designed to operate on a semifinished workpiece constituted by an open vamp (T) previously turned inside-out and glued to a sole (F), the sole (F) being provided, at a perimeter edge (22) thereof, with a step (21) and an oblique slit (23). The machine (M) comprises: a vertical support stud (13), associated to an oscillating arm (14) on which the sole (F) is rested; a spread...

The apparatus for wrapping products with a film made of extensible material comprisesa supply unit (11) having a first spool (12) of extensible material film, a rotation device (3) suitable to produce a relative rotation of said supply unit (11) with respect to the products to wrap, and a shifting device (9) suitableto shift said supply unit (11)with respect to the said products to wrap. The appar...