An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in ...

The invention relates to a method for producing the compound of formula 1, characterized in that a diamine of the formula 2 is converted to a compound of formula 4 by reaction with an oxadiazolone of the formula 3, said compound of formula 4 being converted to the amidine of formula 1 without isolation by hydrating and adding p-toluene sulfonic acid and ammonia.; La presente invención se relaciona...

A composition useful for treating fabrics. The composition contains a silver-containing copolymer having polymerized units of a monomer X and a monomer Y; wherein monomer X is an ethylenically unsaturated compound having a substituent group selected from an unsaturated or aromatic heterocyclic group having at least one nitrogen atom; wherein monomer Y is selected from carboxylic acids, carboxylic ...

Flexible magnetic sheets made with high-energy strontium ferrite, such as to decrease thickness with maintaining a strong magnetic energy (over one Megagause-Oersted) as well as flexibility.; Una hoja magnética flexible hecha con ferrita de estroncio de gran energía, de tal manera que el grosor disminuye con el mantenimiento de la energía magnética fuerte (sobre un Megagause-Oested) tan bien como ...

The present invention relates to a method for producing dendritic cells and their use in medicaments by genetic engineering aimed at functionally improving their therapeutic efficacy in the treatment of cancer, microbial infections, allergies, auto-immune diseases or organ and stem cell transplant rejection.; La presente invención se refiere a un método para producir células dendríticas y su uso e...

The present invention is directed to polypeptide-nucleic acid conjugates. These conjugates can allow for targeted application of a therapeutic RNAi agent across the blood-brain barrier to treat, for example, a cancer, neurodegenerative disease, or lysosomal storage disorder.; La presente invención se dirige a conjugados de polipéptido-ácido nucleico. Estos conjugados pueden permitir una aplicación...

A computer-implemented method for targeting marketing content to an online user, including the steps of collecting profile data describing the user or the user's ownership item and presenting the user with content based on the profile. The user profile includes the user's browsing habits, responses to context-specific survey questions and a photographic likeness of the user or the user's ownership...

A semiconductor solid illuminator comprises a heat-dissipating body (1) provided with a conjoint surface (11) and a plurality of heat-dissipating fins (12) extending from the periphery of the heat-dissipating body (1). The conjoint surface (11) is conjoined with a plurality of illuminants (2). The heat-dissipating body (1) is covered with a lamp shade (3). A reflecting layer (31) is provided on th...

The provision of a pharmaceutical composition for treating an autoimmune disease comprising a pharmaceutically acceptable carrier and an agent capable of activating CD4+CD25+ regulatory T cells, wherein the composition is to be administered to a subject at most every 3 days.; La presente invención proporciona una composición farmacéutica para tratar un enfermedad autoimmune, que comprenden un port...

The present invention relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disea...

This invention relates to a transmission system for transmitting a driving force from a driving unit D to a driven unit F, a transmission adjustment system for adjusting the transmission system to obtain a continuous shift ratio, a guide cone system for maintaining a concentric circle of a rotation radius when a transmission element such as a chain is rotated, a guide cone/transmission adjustment ...

A plastic container is provided having a container body and a closed base. The base includes a base body and a plurality of deflection ribs configured to buckle as the base deforms in response to an increase in negative pressure internal to the container.; Se proporciona un recipiente de plástico que tiene un cuerpo de recipiente y una base cerrada. La base incluye un cuerpo de la base y una plura...

A new family of ordered mesoporous silica materials denoted COK-10 is synthesized under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and optionally a tetraalkylammonium compound. The mesopore size is substantially uniform, is in the range 4-30 nm, and can be fine-tuned by adapting the synthesis conditions. A new family of 2D-hexagonal ordered mesopor...

The invention relates to the development of a food or edible product of oleic origin, which acts as a dental lubricant and is intended to reduce friction between orthodontic wires and brackets, thereby providing low, more continuous physiological forces and, consequently, a significant reduction in orthodontic treatment times. The invention is characterised in that it comprises a base element of o...

A support assembly Is provided for a roller tube that holds sheet material The support assembly has opposed first and second mounts adapted to support the roller tube when rotatably coupled to the mounts The mounts can include slides having a slide member that slides within a slide bracket A support cradle is disposed between the first and second mounts The support cradle is configured to support ...

The one-piece running gear (1) has at least two wheels (2), each mounted to rotate about a shaft (6) on a mounting (7). The rotary shaft (6) of at least one of these wheels (2) can be moved away by at least one spacer means (13), the force for returning it to position being exerted by an endless kinematic running link (3) travelling around the wheels (2), said wheels being kinematically connected ...

A rotational vibration isolator for a sensor is disclosed. The isolator comprises a first enclosure surrounding the sensor and a second enclosure surrounding the first enclosure, with a spherical gap between the enclosures. A fluid is supplied into this gap, the density of the fluid being sufficient to support the first enclosure in a condition of neutral buoyancy. The first and second enclosures ...

The invention relates to an improved process for preparing a new medicament formulation of the active substance dabigatran etexilate of formula I in the form of the methanesulphonic acid salt thereof, and this new medicament formulation as such.; La invención se refiere a un proceso mejorado para preparar una nueva formulación de un medicamento de la sustancia activa etexilato de dabigatrán de fór...

The invention relates to a method for obtaining a plantar image using means for securing and tightening an elastic membrane and for the double-sided machining of the insole thus obtained, said means taking the form of two adjustable horizontal bars positioned on a scanner or a plurality of cameras and an anti-reflective crystal or lens. The invention includes the following steps in which: the memb...

Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.; Se propo...