The use of a Hsp90 inhibitor for the treatment of cancer of the bladder, the colon, the liver, the lung, the breast, the vagina, the ovaries, the pancreas, the kidney, the stomach, the gastrointestinal tract, the prostate, the head and neck, the peritoneal cavity, the thyroid, the bone, the brain, the central nervous system and/or the blood and/or for the treatment of myelodysplastic syndrome, sys...

The invention relates to the use of a mixture of at least one polyol and at least one cyclohexane polycarboxylic acid derivative for reducing or minimizing dust emissions in handling powdered chemical construction products, to a method for producing powdered chemical construction products, and to hydraulically setting compounds containing the mixture according to the invention.

Device 1 for rapidly transferring thermal energy from a heat source A to a point of arrival B at a velocity greater than the convective capacity of the adjacent means 2, enabling the thermal energy to be converted into electrical energy by means of a conversion device 3 positioned at the point of arrival B, the thermal energy being transferred by means of a coating 4 composed of one or more nanoma...

The present invention provides implantable ocular drug delivery devices. Generally, the devices have a distal portion with a coil shaped body member and a proximal portion which contacts the sclera. In one aspect, the coil-shaped body member includes a unique configuration including two coiled portions with different pitches, which improves insertion of the device into the eye. In another aspect, ...

Dosage form of aliskiren, comprising a device for transdermal administration of aliskiren and aliskiren (including salts, prodrugs and metabolites thereof), optionally together with pharmaceutically acceptable carrier(s) to a human being or an animal in order to achieve a desired therapeutic effect. Use of a compound comprising aliskiren, optionally encompassing salts, prodrugs and metabolites the...

Security of packages and other articles of containment if left unattended in crowded public areas will be declared as suspicious raising concerns over the contents of the articles. The laminate construct of the present invention produces a tamper evident construct having at least one layer in combination with cold seal water-based adhesive of a predetermined colour under or over an indicia or imag...

The present invention provides a composition for controlling plant diseases comprising, as active ingredients, ethaboxam and tolclofos-methyl; and so on.

The invention relates to a method for using a mining vehicle, arrangement in a mine, rock drilling rig, and mining vehicle. Tasks according to a work cycle are performed at work sites (19) with a mining work device (2) in a mining vehicle (1). At the work site, the vehicle is connected to an external electrical network (20). An energy storage (26) of the vehicle is charged during the work cycle de...

A towbarless airplane tug configured for receiving a landing gear of an airplane and towing it thereby is provided. The tug comprises a chassis configured for receiving thereon at least a portion of the landing gear, a propulsion arrangement configured to move the tug in a direction along a trajectory, at least one force sensor configured to measure, directly or indirectly, a force exerted by the ...

The present invention is concerned with arylcyclohexylethers of dihydro-tetraazabenzoazulene derivatives, i.e. arylcyclohexylethers of 5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene derivatives of formula (I) wherein R1, R2 and R3 are as described herein. The compounds according to the invention act as Via receptor modulators, and in particular as Via receptor antagonists, their manufacture, ph...

The present invention relates to peptides or peptide like molecules and their uses in therapy, in particular as anti-tumour agents.

The present disclosure relates to protein and peptide chemistry. More particularly, it relates to compounds, compositions and uses thereof for promoting and inhibiting angiogenesis. The peptides of the present disclosure include peptides comprising SEQ ID NOs: 1-4 which promote angiogenesis and cell proliferation. Further, the anti-angiogenic compounds of the present disclosure include antisense o...

Disclosed is a composition for controlling pests, which contains clothianidin and metconazole as active ingredients.

The invention concerns an iron-based powder metallurgical composition comprising an iron or iron-based powder and composite lubricant particles, said composite lubricant particles comprising a core of 10-60% by weight of at least one primary fatty acid amide having more than 18 and not more than 24 carbon atoms and 40-90% by weight of at least one fatty acid bisamide, said core having nanoparticle...

A compound having the structure wherein Y is selected from the group consisting of C(O)OR2, -C(O)NHR8, -C(CH2)1-2OR3, OH, and or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.

The present invention relates to Death Receptor-6 (DR6) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to be important for regulating apoptosis in cells of the nervous system. In addition, it has been discovered that p75 is a ligand for DR6. As a result, this invention relates to methods for inhibiting the interaction of DR6 and p75 using DR6...

A technique includes receiving seismic data acquired in a survey of a region, the region being associated with locations; processing the seismic data to estimate at least one frequency dependent surface wave property over the region; based at least in part on the estimated frequency dependent surface wave property(ies), determining a frequency dependent data processing geometry for each location; ...

The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides and compositions thereof. SEQ ID NO: 1 is a full length S. aureus sequence. A derivative of SEQ ID NO: 1 containing an amino terminus his-tag was found to produce a protective immune response against S. aureus.

The present invention relates to immunoglobulin single variable domains (dAbs) e.g. dAbs which are protease resistant, and also to formulations, and compositions comprising such dAbs for ocular delivery and to their uses to treat ocular diseases and conditions.

Tampons are packaged in a substantially cylindrical wrapper formed of a flexible, sheet-like material that is closed with one or more attachment zones having one or more gaps crossed by a line of weakness. The wrapper is closed at both ends and has a longitudinal seam area in which overlapping portions of the flexible, sheet-like material are attached. The longitudinal seam area comprises a substa...