A method for manufacturing a silicon carbide substrate having a large diameter provided readily includes the steps of: preparing a plurality of SiC substrates each made of single-crystal silicon carbide; and connecting end surfaces of the plurality of SiC substrates to one another such that the plurality of SiC substrates are arranged side by side when viewed in a planar view.

Disclosed is a multilayer bonding method which is provided with: a step of manufacturing a first bonded substrate by bonding together an upper substrate and an intermediate substrate therefor inside of a bonding chamber; a step of carrying a lower substrate for the first bonded substrate into the bonding chamber when the first bonded substrate is disposed inside of the bonding chamber; and a step ...

The present invention provides steel plate for line pipe excellent in strength and ductility and a method of production of the same. The steel plate has a steel composition containing, by mass%, C: 0.04 to 0.15%, Si: 0.05 to 0.60%, Mn: 0.80 to 1.80%, P: 0.020% or less, S: 0.010% or less, Nb: 0.01 to 0.08%, and Al: 0.003 to 0.08%, having a balance of iron and unavoidable impurities, and having a va...

A medical system (10) for performing a tissue biopsy at a remote lo-cation within a patient is disclosed. The medical system comprises an elongate outer cutting member (14), an elongate inner member (22) movably disposed within the outer member, and a tissue traction member (24) for anchoring bodi-ly tissue and pulling a sample of the tis-sue within the outer cutting member.

A method of assessing the integrity of a rock mass, the method including receiving a thermal assessment of the integrity of a rock mass, receiving an acoustic assessment of the integrity of a rock mass and correlating the thermal- and acoustic assessments to obtain a combined assessment of the integrity of a rock mass. The invention also covers an assessment apparatus for assessing the integrity o...

Provided herein are compositions and methods for gene and etiology-nonspecific and circuit- specific treatment of diseases, utilizing vectors for delivery of light-sensitive proteins to diseased and normal cells and tissues of interest.; Se proveen en la presente métodos y composiciones para el tratamiento genético y no específico etiología y específico de circuito de enfermedades, utilizando vect...

A window shade that reduces the risk of an individual becoming entangled in cords used to operate the shade includes a headrail adapted for horizontal mounting above a window, a shading material attached to the headrail, and at least one cord for raising and lowering the shading material. The cord is attached to a location adjacent a lower end of the material, and extends upward through cord guide...

The present invention describes a chimeric protein acting as a hTNF-a antagonist, which avoids the link between this latter element and the natural receptor thereof, thereby blocking the beginning of a physiological event chain which finally leads to the appearance of signs and the development of symptoms characteristic of diseases where the human alpha tumour necrosis factor is increased. The hTN...

The purpose of the invention refers to a wide-spectrum germicide against bacteria, virus and fungi. The invention consists of a concentrated solution of silver, copper and/or zinc ions; a vegetable organic solvent, which has natural healing properties. The germicide may be manufactured through 2 main paths: A.- Manufactured by the proportional combination of 2 or more chemical formulas which conta...

O PRESENTE MODELO DE UTILIDADE ? UM ESTEIO REDONDO EM BET?O PR?-ESFOR?ADO, DE COMPRIMENTO E ESPESSURA VARI?VEIS, DESTINADO A VINHAS, POMARES E VEDA??ES DE ?REAS AGR?COLAS E URBANAS. O ESTEIO, EM TODO O SEU COMPRIMENTO, TEM A FORMA DE UM CIRCULO INCOMPLETO, CUJA BASE ? PLANA. ESTA BASE RESULTA DO ASSENTAMENTO DA PE?A NO PROCESSO DE FABRICA??O EM PISTA. O PRESENTE DE MODELO DE UTILIDADE CONT?M, NO S...

A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein...

A sulfamoyl compound of the general formulae (1): wherein R<1> and R<2> are each independently C1-4 alkyl, or R<1> and R<2> together are C4-6 alkylene or C4-6 alkyleneoxy, Y is H, halogen, C1-8 alkyl, C1-8 alkoxy, C1-8 alkylthio, C1-8 haloalkyl, C1-8 haloalkoxy or C1-8 haloalkylthio, A is a predetermined heterocyclic group, B is a predetermined heterocyclic group which is identical wit...

Sympathetically maintained peripheral neuropathic pain syndromes are relieved by topically applying, to the affected region of a patient suffering from such pain, a pain relieving amount of an aqueous gel comprising clonidine, a water-gelling amount of a pharmaceutically acceptable gelling agent and having a physiologically tolerable pH value. Pain relief was achieved with applied amounts of cloni...

A carrier and localization system for active or functional molecules (A) comprising particles of biodegradable polyester (I) having a single or multiple functionalized surface layer of proteins covalently or non-covalently bonded to (I) and/or amphiphilic molecules non-covalently bonded to (I), is new.

A liner for a patch used for covering the surface of a base agent layer of the patch is provided. In the liner of the invention, a tear line portion for dividing and peeling the liner off the base agent layer is provided at a predetermined location, and the thickness of the tear line portion is made thinner than a generally average thickness of the liner. Therefore, when the patch is about to be u...

The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction of the substrate.

Novel pyrimidine derivatives of formula (I), to processes for their production, their use as IGF-1R and ALK-inhibitors in the treatment of neoplastic diseases, inflammatory and immune system disorders and to pharmaceutical compositions comprising them.

Liquid cationic starch compositions (I) with a dry substance content of at least 10 (preferably 10-50) %, a viscosity (T test) of 200-1000 mPa.s, a total nitrogen content of 0.6-1.4 wt% based on dry weight of (I), and a pH below 9, preferably 3.5-8.5.

A process for the production of a substrate having antimicrobial properties is described. It comprises a step consisting of the deposition of a metal non-gelling layer comprising an inorganic antimicrobial agent, starting from a precursor, in metal, colloid, chelate or ion form on at least one of the surfaces of the metallic substrate; and a step consisting of the diffusion of the agent into said ...

TGF-beta 1 binding compositions and reagents related thereto are provided. Methods of using such compositions for therapeutic purpose are also provided.