The present invention provides an improved method of synthesizing 2´-O-R substituted pyrimidine mononucleosides. The method comprises reacting an anhydropyrimidine with magnesium alkoxide in the corresponding alcohol at elevated temperatures to directly produce the 2´-O-R substituted pyrimidine nucleoside product. The method advantageously eliminates several steps from prior art methods, thereby r...

The process for the synthesis of modified P-chiral nucleotide analogues in the form of pure diastereomer possessing preselected configuration at the P-atom. Antisense oligonucleotides containing P-chiral compounds have enhanced hybridization and transporting properties.; Procédé permettant de synthétiser des analogues de nucléotides chiraux P modifiés, qui se présentent sous la forme de diastéréoi...

A triplex forming oligonucleotide is complementary pursuant to the G/T or A/G recognition motif to a homopurine, or substantially homopurine target sequence in double stranded nucleic acids, and at least one and preferably all of the guanine bases are replaced by their pyrazolo[3,4-d]pyrimidine analog, namely by 6-amino-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one. The oliginucleotides containing the pyr...

The invention relates to the chemical synthesis of oligonucleotides and to chemical entities useful in such synthesis. More particularly, the invention relates to sulfurization of the internucleoside linkages of oligonucleotides. The invention provides new sulfur transfer reagents of formula (1) and processes for their use in sulfurizing oligonucleotides. The sulfur transfer reagents according to ...

Disclosed are bioactive substances useful for the delivery of effector units in animals. Also disclosed are methods for utilizing the bioactive substances of the invention.; L'invention porte sur des substances bioactives servant à véhiculer des unités effectrices dans des animaux, et sur des procédés d'utilisation desdites substances bioactives.

The invention provides new processes for synthesizing oligonucleotides that allow for deprotection of the oligonucleotide under more rapid and/or more mild conditions than existing methods. The invention further provides a nucleoside base protecting group of formula (I) that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing prot...

Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.; Bibliothèques combinatoires de polycétides qui peu...

Video signals and audio signals of a received program are constantly recorded on a hard disk. When a command for program storage is provided, rewrite of a recorded area on the hard disk is inhibited, and the program can be stored on the hard disk retroactively within a range not exceeding a predetermined time period. Also, the program is recorded on the hard disk up to an end time of the program. ...

The respective square cross section permanent magnets of each of a plurality of spaced Halbach magnet arrays, attached to the bottom of movable X-Y stage and aligned with a given one of the X and Y axes, are spaced from one another parallel to the other one of the X and Y axes by the width of the square cross section cooperates with both a first set of a plurality of flat stationary electromagnet ...

The present invention provides a multistep electronic circuit device comprising a plurality of parts and elements mechanically or electrically bonded in sequence to each other and to a substrate with a plurality of solders, which comprises as the parts and elements the substrate, input and output pins and LSI chips, and optionally packages and a cooler bonded through multistep bonding, the bonding...

PROBLEM TO BE SOLVED: To reduce data to be stored by providing each of means for generating array, data reception, array content reference and compression in addition to the number of frames between pictures and information so as to edit image data efficiently. SOLUTION: A computer 7 and an external device 15 are connected via a transmission line 14 and a box 13. A CPU 8 executes a basic program s...

Fluorine-containing, chiral liquid crystal compounds comprise (a) an aliphatic fluorocarbon terminal portion containing at least two catenary ether oxygen atoms; (b) a chiral, aliphatic hydrocarbon terminal portion; and (c) a central core connecting the terminal portions. The compounds have smectic mesophases or latent smectic mesophases and are useful, for example, in liquid crystal display devic...

A memory cell array (20) provided with memory cells (M) at respective intersecting points of a plurality of word lines (WL1-WLm) and a plurality of bit lines (BL1-BLn), a bit line selecting circuit (21) which is in connection with the plural bit lines (BL1-BLn) and selects the plural bit lines, a potential feeding circuit (22) which is in connection with the plural bit lines (BL1-BLn) via the bit ...

A method for on-line reconstruction of a failed storage unit in a redundant array system. After providing a replacement storage unit for the failed storage unit, reconstruction begins for each data stripe in the array. General reconstruction consists of applying an error-correction operation (such as an XOR operation on data blocks and a corresponding parity block) to the data blocks from the rema...

For precise control of the temp. of the individual elements on a thermal printing head, individual temp. sensors are used in conjunction with a temp. control algorithm. The existing and previous settings of the printing elements are stored in a memory. To calculate the required heating voltage for a single element, its required setting (DO) is combined with previous settings for it and its immedia...

Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.

A compound having formula (I), wherein R is selected from the group comprising C5 to C20 alkyl, C5 to C20 cycloalkyl, halogens, aryl and alkylaryl; R' is selected from the group comprising hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, alkyl; R'' is selected from the group comprising hydrogen, alkyl, cycloalkyl, ...

Compounds that are synthetically inexpensive to make relative to the naturally occuring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs or derivatives of these groups, such that sialic acid and fucose are separated by a non-carbohydrate linker that permits binding between those grou...

Video and telephony messaging are integrated by a telephony multimedia messaging system (101) connected to a plurality of video workstations (103-104) by a LAN or WAN (100). The workstations are connected to ISDN telephone lines (153-154). The workstations answer video calls on the video lines and/or on the LAN or WAN that go unanswered by users, record video messages from the video calls, and sen...