The present invention provides identification and characterization of conformational epitopes of the envelope protein E2 of the Hepatitis C virus (HCV). The present invention provides a panel of human monoclonal antibodies that recognize conformational epitopes of E2. The antibodies are derived from patients infected with HCV. The present invention provides methods for utilizing HCV antibodies as ...

The invention features compounds of formula (I) or (II). In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppressio...

The invention concerns a device (100) for the production and the controlled dispensing of soft ice cream or similar products, comprising: - A refrigerator body (6) suitable to treat a pre-determined amount of ice-cream; - A dispenser (1a,2,3,4,4a,5) of ice-cream; - Means (7) for the mixing and the forwarding of the ice-cream to the dispenser (1a,2,3,4,4a,5); and characterised in that the dis...

It is described a gold nanoparticle coated with from two to five layers of a combination of a polyelectrolyte having amino functionality and a polyelectrolyte having sulfonic functionality, or with one single layer of said polyelectrolyte having amino functionality, preferably polyallylamine, or sulfonic functionality, preferably polystyrenesulfonic, characterized in that said nanoparticle compris...

A hinged door (P) for elevator or lift platform, comprising at least one wing (4) suitable to be hinged to an upright (M), characterized in that said wing (4) comprises a frame structure defined by at least one vertical jamb (1) connected to said upright (M), a glass or crystal glass (6), curved in shape, fastened to said jamb (1), said jamb (1) being defined by at least one outward facing cover...

The device comprises: an inner chamber (56) which has an upper aperture or mouth (36) and is delimited by a lateral wall (20) and by a base wall (19), and which is intended to contain a primary fuel to be subjected to gasification and/or pyrolysis or vaporization to generate combustible gases; an outer chamber (58) delimited by an outer lateral wall (22) positioned coaxially with the outside of th...

A machine for forming at least a metal mesh comprising longitudinal wires and transverse wires, comprising at least a welding unit provided with a plurality of welders by means of which the longitudinal wires are welded to corresponding transverse wires, each of the welders comprising at least two electrodes, respectively upper and lower, selectively movable between a first feed position, in which...

A leg guard (1) for horses comprising: an elastically yielding thin member (2) designed to be wrapped around the lower leg (3) of the horse, with a contact surface (4) that is positioned up against the lower leg (3); a shaped, shockproof shell (5), associated with the thin member (2) on the side opposite said contact surface (4); closing means (6) designed to tighten the thin member (2) around the...

A tool for marking decorative lines or strips on a surface comprising a main frame (2) that defines a longitudinal axis (L)1 a handle (3) fixed to said frame (2), a first deposition roller (4) rotatably mounted to said frame (2) to rotate about a first substantially transverse axis (A) and having an outer peripheral portion (14) conformed for marking a line or a decorative strip (H)1 means (5) for...

A solid fuel heating equipment with improved structure, including a brazier (11) of a combustion chamber (14), inside which the burning of the solid fuel occurs and accessible to the user through a front opening door (13), and at least one tank (15), containing solid fuel, on the bottom of which one sealing mobile door (23) is installed, connected with driving means (31, 35), which cause the openi...