ESTA INVENCION SE REFIERE A (1, 8)NAFTIRIDIN-2-ONAS Y A COMPUESTOS RELACIONADADOS, A METODOS PARA FABRICAR TALES COMPUESTOS, A COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y A SU USO PARA SU USO PARA EL TRATAMIENTO DE LA EZQUIZOFRENIA Y OTROS TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL.; This invention relates to compounds of the formula 1 wherein G, D, A, Z, Q, X, Y, R¹, and R⁴

ESTA INVENCION SE RIFIERE A LOS ANALOGOS NOVEDOSOS DE QUINOLINA Y A LOS DERIVADOS DE LOS MISMOS, INCLUYENDO LOS DERIVADOS FARMACEUTICAMENTE ACEPTABLES, TALES COMO LASA SALES Y LOS SOLVATOS.; The invention relates to compounds represented by Formula (I): and to pharmaceutically acceptable salts or solvates of said compounds, wherein each of A, R^3-8, X³, X⁵, m, and n...

ESTA INVENCION SE REFIERE A COMPUESTOS QUE ACTUAN COMO INHIBIDORES DE TIROSINA, QUINASA Y SON UTILES EN PROCEDIMIENTOS PARA TRATR, PREVENIR O INHIBIR ENFERMEDADES PROLIFERATIVAS, INCLUYENDO CANCER, ATEROSCLEROSIS, REESTENOSIS, ENDOMETRIOSIS Y PSORIASIS; This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted b...

LA INVENCION SE REFIERE GENERALMENTE A NUEVOS COMPUESTOS Y PROCEDIMIENTOS QUIMICOS.; Compounds of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

La presente invencion se refiere a una nueva forma de sal del agonista de dopamina 5-[(2R,5S)-5-metil-4-propilmorfolin-2-il]piridin -2-amina.; This invention relates to a novel salt form of dopamine agonist 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine (I): More particularly, this invention relates to 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine di-(1S)-camphorsul...

LA INVENCION PROPORCIONA VARIANTES DEL PEPTIDO PYY3-36 Y SUS DERIVADOS PEGILADOS Y COMPOSICIONES Y METODOS UTILES EN EL TRATAMIENTO DE ESTADOS MODULADOS POR EL AGONISTA DEL RECEPTOR Y2 DEL NEUROPEPTIDO Y (npy).; The invention provides PYY3-36 variants and pegylated derivatives thereof and compositions and methods useful in the treatment of conditions modulated by an NPY Y2 receptor agonist.

LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS Y A SUS DERIVADOS, QUE SON DE UTILIDAD EN TERAPIA Y A PROCESOS PARA SU PREPARACION; Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein R¹ and R³ independently represent H, C_1-6alkyl, C_3-8cycloalkyl, or halogen; R² represents C_1-6alkyl, CF_{3 ...}

The present invention provides a method and system for improving the client-Servlet communication in the World-Wide-Web (Web) without changing the existing communication protocol, and without changing the client. The existing prior art one-way communication path between client and Servlet remains unchanged if the initial request includes all information for retrieving the desired information. Howe...

A structure for a chip or chip package is disclosed, with final passivation and terminal metallurgy which are mechanically decoupled but electrically coupled to the multilayer on-chip interconnects. This decoupling allows the chip to survive packaging stresses in the final passivation region, with strain relief from the decoupling region and compliant leads therein, so that on-chip interconnect le...

A servo control system micro-electromechanical systems (MEMS)-based motion control system (and method therefor), includes a motion generator having an inherent stiffness component.

A mechanism and model are provided for representing and managing composite resource models. When a resource monitor is deployed for a resource, the resource monitor scans for information that indicates that the resource under monitoring is part of a cluster, grid, or other composite configuration. The resource monitor then determines whether monitoring information for the resource should be report...

A hybrid substrate having a high-mobility surface for use with planar and/or multiple-gate metal oxide semiconductor field effect transistors (MOSFETs) is provided. The hybrid substrate has a first surface portion that is optimal for n-type devices, and a second surface portion that is optimal for p-type devices. Due to proper surface and wafer flat orientations in each semiconductor layers of the...

A series of content information; menu information, which is to be displayed with the content information during reproduction of the content information; and play list information for defining reproduction sequence of the content information by a unit of item, which constitutes the content information and which is accessible upon reproducing, are recorded on the information record medium. The play ...

The present invention relates to a method for realizing HARQ in multi-carrier cell, comprising: when distributing high-speed shared resource for UE, Node B distributes the high-speed downlink packet service to N frequencies, and reports the information of the established physical channel, including the frequency information, to RNC and said UE; after Node B establishes the high-speed shared resour...

A liquid crystal device comprising: at least a pair of substrates; and a Smectic phase liquid crystal material disposed between the pair of substrate. The molecular long axis or n-director of the Smectic phase liquid crystal material has a tilt angle to its layer normal as a bulk material, and the molecular long axis of the Smectic phase liquid crystal material aligns parallel to the pre-setting a...

The invention relates to α-oxygenated or α-thiolated carboxylic acid phenethylamide derivatives of general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substituted aryl or optionally substituted heteroaryl; X is oxygen or sulfur; Y is oxygen or sulfur; R1, is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, ha...

Compounds of formula (I), pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals

A pigment dispersion composition which can be suitably applied in such fields as color filters, black matrices and ink jet recording where it is necessary to finely disperse pigments still with retention of good dispersion stability and temporal stability even when the total amount a pigment derivative, pigment intermediate, colorant derivative and colorant intermediate, and/or a pigment dispersan...

A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weigh...

To provide a game machine capable of reducing a sense of discomfort which the user feels due to unmatched image display timing and image-related sound output timing. An image reproduction unit (highlight scene image reproduction control unit (72)) reproduces an image. An image-related sound reproduction unit (comment sound reproduction control unit (78)) reproduces an image-related sound correspon...