PCT No. PCT/EP95/04815 Sec. 371 Date May 16, 1997 Sec. 102(e) Date May 16, 1997 PCT Filed Dec. 7, 1995 PCT Pub. No. WO96/18633 PCT Pub. Date Jun. 20, 1996Erythromycin 9-oxime derivatives wherein a phenyl or heterocylic group is attached indirectly to the 9-position of erythromycin A through an alkylene diamine bridging member. These compounds exhibit broad spectrum antibiotic activity.

Compounds of formula (1) and their salts, wherein R<1> is a methyl, ethyl or isopropyl group each substituted by a hydroxyl group or R<1> is a group -(CH2nR7 or a group -CH(CH3)R<7> (where n is zero or 1 and R<7> is CHO or CO2H); Y<1> is -CH2-, Y<2> is -CH- and X represents [where R<2> is a hydrogen atom or a group OR<8> is a hydroxyl group or a substituted hydroxyl group having up ...

A one-component system polyurethane gel and a coupler for ultrasonic diagnostic probes comprising the same are disclosed. The gel is obtained by reacting a polyol having a room temperature liquid alkylene oxide chain and/or a polyurethane polyol prepolymer having a room temperature liquid alkylene oxide chain with a polyurethane polyisocyanate prepolymer having a room temperature liquid alkylene o...

This invention relates to methods for detecting polynucleotide sequences using nucleic acid hybridization procedures. In particular, the invention concerns the use of oligonucleotides covalently attached to a polymer to increase the rate and extent of capture of specific target nucleic acid contained in a biological sample. In a preferred method, the target nucleic acid in the sample is exposed to...

A method for producing polymer-based floor or wall coverings, wherein polymers modified by high-polarity comonomer groups are mixed with mineral fillers, and sheets, strips or tiles are produced according to conventional methods for PVC in order to produce abrasion-resistant materials which are particularly suitable for producing floor or wall coverings. Abrasion-resistant products obtained using ...

This invention relates to a novel process for preparing 2-chloro-2 min -deoxyadenosine (2-CdA) having the following formula from a compound of the following formula The invention also relates to intermediates which are useful in preparing 2-CdA. The compound 2-CdA is useful as an antileukemic agent, i.e., in treating leukemias, such as hairy cell leukemia.

A 3-(substituted carbonyloxy)-5-O-desosaminylerythronolide derivative represented by general formula (I), which is useful as a novel macrolide antibiotic with a potent antibacterial power, wherein R' and R'' represent each hydrogen or acyl; Y represents optionally substituted alkylene, ether linkage, acid linkage or vinylene; R represents hydrogen, optionally substituted alkyl, aryl or heteroaryl;...

New compounds having the general formula I wherein Y may be H or D; and A is H, D, alkyl with 1-4 C-atoms, halogen, nitro, amino, monoalkyl amino or dialkyl amino wherein the alkylgroups have 1-4 C atoms or OR wherein R is H or alkyl of 1-4 C-atoms; X1 and X2 may together with the carbon atom to which they are bound form a cyclic acetal, thioacetal, dithiane, aminal, oxazolidine or thia...

Device for assembling, by screwing, at least two components (1, 2), including a support plate (5) for the two preassembled components, which support plate can move with respect to a fixed station (8), with means (7) for indexing its position with respect to the fixed station, a rotary driving member (9) equipping the fixed station (8) and able to move, in the latter, between a retracted position a...

Disclosed are deoxyfructonucleotides and dideoxyfructonucleotides represented by formula (I) which may be used as propagators and terminators in DNA extension reactions, wherein R<1> is H2PO3, H3P2O5, H4P3O7 or the salts thereof, or H; B is a naturally occurring nucleic acid base or synthetically modified nucleic acid base; R<2> is OR<3>, N3, Y-Biotinoyl, or NHC=O(CH2)nY-Biotinoyl; wherein: R<3> i...

Disclosed is a substrate useful for separating unmodified and modified mononucleotides and oligonucleotides. The substrate includes at least 12% (weight:volume) polymer in at least 5M urea and at least 32% (volume:volume) organic solvent, the organic solvent being a chemically stable liquid at room temperature and having a dielectric constant of at least 20. Also provided is a method of separating...

The invention describes a device for reception of at least one sonography probe (12) which can be adjusted and fixed on the skull of a patient by means of a frame (10a) which can be attached thereto and on which the probe (12) rests adjustably in a probe mount (44). In this device, the frame (10a) resembles spectacles and comprises a bridge (55) and a pair of retaining brackets (16a) adjoining the...

The invention concerns a switching and/or control method and device which use a computer and in which the brain waves of a person are detected and converted into digital switching and/or control commands. According to the invention, in order to be able to reproduce output signals more accurately and reliably in a method and device of this type, the brain wave signal pattern (c, d) is compared with...

In the preparation of (meth)acrylic esters of carbohydrates with at least one free hydroxyl (OH) group in the molecule, selected from sucrose, sugar alcohols and glucosides, by ester exchange with the (meth)acrylic ester of a lower alcohol, an alkali carbonate and a quaternary ammonium salt of formula (I) are used as ester exchange catalysts. R-N?+(R')3.X?- (I) R = 4 - 20C alkyl; R' = 1 - 8C alk...

Oligodeoxynucleoside methylphosphonate neoglycopeptide conjugates and related compounds for tissue specific delivery of biologically stable, non-ionic oligodeoxynucleoside analogs into cells.

Derivatives of 16-membered ring 3-deoxy macrolide antibiotic derivatives of rosaramicin, repromicin, 5-mycaminosyltylonolide, desmycosin, lactenocin, O-demethyllactenocin, cirramycin A1, and 23-deoxymycaminosyltylonolide, which are useful against bacterial and mycoplasmic pathogens in animals.

The invention provides improved oligonucleotides having greater resistance to nucleolytic degradation by virtue of having alkylphosphonothioate or arylphosphonothioate internucleotide linkages.

A nucleic acid analogue of the PNA type is provided with a kemptide motif and radio-labelled by phosphorylation at a service residue in said motif to provide a radio-labelled nucleic acid analogue having a specific activity in excess of 1 x 10<5> cpm/ mu g <32>P.

Discloses novel biodegradable high performance hydrocarbon base oils useful as lubricants in engine oil and industrial compositions, and process for their manufacture. A waxy, or paraffinic feed, particularly a Fischer-Tropsch wax, is reacted over a dual function catalyst to produce hydroisomerization and hydrocracking reactions, at 700 DEG F.+ conversion levels ranging from about 20 to 50 wt. %,...

The digital data of a plurality of video/sound application programs are stored in a plurality of large-capacity random access storage devices (9), and a controller (8) instructs multichannel output decoders (6 and 7) to read out the video/sound application programs and vacant channel numbers. The decoders (6 and 7) intermittently read out the video/sound programs in blocks from the storage devices...