Prodrugs of C-17-heterocyclic- steroidal drugs providing improved oral bioavailability and phamacokinetics are described. The drugs are inhibitors of human CYP 17 enzyme, as well as potent antagonists of both wild type and mutant androgen receptors (AR), and are useful for the treatment of urogenital and/or androgen-related cancers, diseases and/or conditions, such as human prostate cancer, breast...

A method for producing multi-layered elastomeric film or article, the method comprising: (i) dipping a mould into a composition for producing an elastomeric film having a total solids content of between 5 % - 40 % to produce a layer of elastomeric film composition on the mould, (ii) partially drying the layer of elastomeric film composition on the mould to reduce the total water content of the ela...

Methods, compositions, devices, and systems for administration to a biological tissue of a composition comprising a chlorine dioxide source are provided.

Methods, compositions, devices, and systems for administration to a biological tissue of a composition comprising a chlorine dioxide source are provided.

The invention concerns lake compositions based on natural macromolecules (gelatin, chitosan, pectine etc.) with possible additions of vinyl polymers, metal-alcoxides etc., characterized by a barrier effect modulated in situ, in particular as a function of the relative humidity in the exterior ambient.

A method for differentiating a human differentiated cell-derived pluripotent stem cell into a neural stem cell is provided, which includes the steps of: making an embryoid body from the human differentiated cell-derived pluripotent stem cell; and culturing the embryoid body in a medium containing LIF to differentiate into a neural stem cell, so that, when the neural stem cell is allowed to differe...

Disclosed is a remotely monitorable shipping container security and integrity system and radio frequency identification device. The system permits remote monitoring of shipping containers via RFID devices capable of data storage. The RFID devices are adapted to become at least partially non-functional in the event of substantial tampering.

La invencion se relaciona con derivados de alcanos azabiciclicos sustituidos con biarilo, con composiciones que comprenden di- chos compuestos y con metodos para tratar afecciones y tras- tornos usando dichos compuestos y dichas composiciones.; The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and ...

A firearm enabling and disabling electronic system comprising a base unit (1 ) and a safety device (4) adapted to be incorporated into a firearm (7). Each of the base unit (1 ) and the safety device (4) has a transmitter and/or receiver (2, 5) adapted to exchange and process wireless command signals with each other. The safety device (4) has an actuating circuit (6) which is controlled by the tran...

La presente invencion se refiere a procedimientos para la proteccion de fruta cosechada, flores cortadas o hortalizas contra la podredumbre causada por ciertas enfermedades de almacenamiento o trastornos expresados en condiciones de almacenamiento. En particular, la invencion se refiere a la aplicacion de ciertos compuestos con actividad fungicida para proteger fruta cosechada, flores cortadas o h...

Metodo para modular la vida media del plasma del anticuerpo anti-glipican 3, una composicion farmaceutica que comprende un componente efectivo del anticuerpo anti-glipican 3 que tiene una vida media de plasma que ha sido modulada, se suministra un metodo para preparar el anti-glipican 3 y una composicion farmaceutica que comprende el anticuerpo anti-glipican 3 como un componente efectivo.; A metho...

La presente invencion provee compuestos de utilidad, por ejemplo, para el tratamiento de trastornos metabolicos en un sujeto. Estos compuestos tienen la formula general I.; The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present inv...

Methods and systems for spam reporting with a message portion are described. In one embodiment, an electronic message is received on a mobile electronic device. A spam report policy is used on the mobile electronic device to identify a portion of the electronic message to include with a spam report. The spam report is transmitted from the mobile electronic device to a server, the spam report notif...

The invention relates to a method for extracting methane from methane hydrates, comprising the following steps: feeding carbon dioxide to the methane hydrate deposits; allowing the carbon dioxide to take effect on the methane hydrate to release methane and store the carbon dioxide as carbon dioxide hydrate; and removing the released methane, characterised in that the fed carbon dioxide is supercri...

A method of detecting a predisposition to, or the incidence of, colorectal cancer in a faecal sample comprises, in a first step (a), detecting the presence of blood in the faecal sample, wherein detection of the presence of blood is indicative of a predisposition to, or the incidence of, colorectal cancer. The method additionally comprises, in second step (b), detecting an epigenetic modification ...

Disclosed herein are compositions comprising a solubilizing agent for the removal of burnt-on, cooked-on, baked-on, dried-on and charred organic food and oil residues from surfaces comprising alcohol, a coupling agent, water, an anti-deposition agent, a pH buffer and a surfactant system that preferably includes a fermentation supernatant, where the supernatant contains essentially stress proteins....

Methods are disclosed for fortifying a sports drink with one or more citrus phytochemicals while concealing the bitter taste of these compounds in the beverage. These methods comprise microencapsulating the citrus phytochemicals and adding the microencapsulated citrus phytochemicals to the beverage. Also disclosed are sports drinks fortified with one or more microencapsulated citrus phytochemicals...

Methods are disclosed for fortifying a beverage with one or more citrus phytochemicals while concealing the bitter taste of these compounds in the beverage. These methods comprise microencapsulating the citrus phytochemicals and adding the microencapsulated citrus phytochemicals to beverages. Also disclosed are beverages fortified with one or more microencapsulated citrus phytochemicals but which ...

Methods are disclosed for fortifying a sports drink with one or more citrus phytochemicals while concealing the bitter taste of these compounds in the beverage. These methods comprise microencapsulating the citrus phytochemicals and adding the microencapsulated citrus phytochemicals to the beverage. Also disclosed are sports drinks fortified with one or more microencapsulated citrus phytochemicals...

L'invention concerne les nouveaux produits de formule (I): (I) dans laquelle (II) représente une liaison simple ou double; Ra représente -O-Z-Rc avec Z simple liaison ou alkylène éventuellement substitué et Rc représente cycloalkyle, hétérocycloalkyle, aryle ou hétéroaryle éventuellement substitués; Rb représente H ou F; avec si Rb est H, alors Rc n'est pas cycloalkyle quand Z est simple liaison e...