Novel dolasstatin derivatives of the formula (I): R<1>R<2>N-CHX-CO-A-B-D-E-(F)tK, in which R<1>, R<2>, A, B, D, E, F, K, X and t have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

An intramedullary nail comprises a unitary piece of elongate material of tubular cross-section having variations in wall thickness along its length. The nail has a proximal portion, a distal portion and an intermediate portion between the proximal and distal portions. The wall thicknesses of the proximal and distal portions are substantially greater than the wall thickness of the intermediate port...

The invention relates to a packaging box for tablets, comprising a closing flap (2) having a dispenser chamber (3) that is open toward the interior of the container (1), has a substantially rectangular cross section and can pivot around a hinge (4). Its pivoting axis extends perpendicular to the larger plane of the container, wherein locking means are configured between the inner wall of the conta...

The present invention is grounded on the problem, how to conceive appropriate a feeding device (200) for transferring identification bracelets (1) or similar annular attaching requisites equipped by appropriate electronic data carrier to appropriate electronic data reader, so that just one-way collecting of the bracelets (1) or similar annular attaching requisites as well as positioning thereof in...

The invention concerns a method for preparing 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A and its 8a-alkyl derivatives from 9-deoxo-9(Z)-hydroxyiminoerythromycin A via a Beckmann stereospecific rearrangement in a reaction medium using pyridine as main solvent, leading to imidate intermediates which are not isolated from said medium and which are directly engaged in a reduction step using a s...

A compound of the formulawherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.

Devices for monitoring the deformation of three-dimensional objects thanks to the presence of sensors integrated in the device are described.

The invention concerns a gas bottle in particular for medical use, comprising a generally cylindrical bottle body (1) comprising members (3) regulating gas output and optionally a protective covering (2) arranged around the members (3) regulating gas output. The invention is characterised in that the bottle body (1) is at least partly covered with at least a first protective casing (11), and the m...

Se describe un mecanismo para el accionamiento por compresion, por medio de una tecla basculante, de controles electricos tales como conmutadores selectores y similares, en el cual estan provistos al menos un contacto fijo y un contacto movil, portado por una armadura movil, accionada en forma girable para llevar el contacto movil hacia o lejos del contacto fijo, a traves de un pasador operado por...

The protective packaging for cylindrical objects comprises a band of card or plastic (1). This has one or more grooves (4) around it which act as seatings for a binding strip (2) of metal.

Ceretain aza cyclohexapeptide compounds have been found to have superior antibiotic properties. Novel processes for their preparation are also described.

This invention directed to a computer tomography imaging apparatus designed for dental use as well as to methods realizable by it, especially to a method for relative positioning of the imaging means and the patient for imaging. A relevant feature of the computer tomography imaging device according to the invention is an arm construction consisting of turnable arm parts. The use of the constructio...

A detergent and disinfectant in which water-soluble permanganates are used in an alkaline solution in order to initiate the oxidation of organic substances and simultaneously a chemical oxidant, preferably a peroxodisulfate, is used which is capable of producing radical reactions with catalytic support by manganates originating from the supplied permanganate, which reactions produce the oxidation ...

A method and system for processing telephone calls within a digital wireless telephone system is described. During the initiation of a telephone call from a wireless subscriber unit, it is determined whether the receiving subscriber unit is also part of a digital wireless telephone system that has compatible vocoding capability. If so, vocoded data from the digital wireless telephone system is con...

PCT No. PCT/DE96/01350 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 24, 1996 PCT Pub. No. WO97/19542 PCT Pub. Date May 29, 1997A method and an arrangement for synchronizing a receiver for digital signals are described. The synchronizing information is derived from the center of distribution of the squared channel impulse response, which center of distribution is calcul...

The invention is directed to a glass container having provided on at least one surface thereof a polymer based coating and/or a polymer label, said surface being provided with a precoating of at least one polyvinyl alcohol, underneath said polymer based coating and/or a polymer label.

A transmyocardial implant establishes a blood flow path through a myocardium between a heart chamber and a lumen of a coronary vessel residing on an exterior of the heart. The implant includes a coronary portion sized to be received within the vessel. A myocardial portion is sized to pass through the myocardium into the heart chamber. A transition portion connects the coronary and myocardial porti...

A directional control valve for a hydraulic load has, in a piston bore of a valve housing, a control piston which can be displaced axially in opposite directions from a central position and which has first fine control grooves for opening a connection between a load chamber and a feed chamber. There are second fine control grooves for opening a connection between a load chamber and a discharge cha...

A former head allows processing of long fibers while achieving a carding action and a fibre distribution fulfilling high quality standards. The former head contains at least one needle roller. A mixture of air and fibers are injected above the horizontal plane of a center axis of the needle roller and directly onto a periphery of the needle roller. There may be a number of adjustable needle roller...

A vertically integrated sensor structure (60) includes a base substrate (71) and a cap substrate (72) bonded to the base substrate (71). The base substrate (71) includes a transducer (78) for sensing an environmental condition. The cap substrate (72) includes electronic devices (92) formed on one surface to process output signals from the transducer (78). The sensor structure (60) provides an inte...