The machine comprises an identification device (1) for accepting suitable or ejecting unsuitable used cups, which on being accepted are conveyed through an inlet mouth (2) towards a bin (3), following a journey whereon are situated one or more operative groups (20, 30), through which the cups (17) pass and are treated such as to render them easier to contain.

A compound of the formula wherein the symbols define certain groups or atoms, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also comprises a biologically pure culture of the microorganism Streptomyces violaceoniger No. 9326 ...

The invention relates to derivatives of 12,13-epoxy-tylosin, the novel semisynthetic antibiotics from the tylosin group and the methods for their preparation. According to this invention hydrogenation followed by oximation of 12,13-epoxy-tylosin derivatives yieldsthe following tylosin derivatives: 10,11-dihydro-12,13-epoxy, respectively 10,11-dihydro-12,13-epoxy oxime. Direct oximation of 12,13-ep...

This invention relates to fluoromethylphosphonate derivatives of certain nucleosides, to methods for their preparation and to their use as antiviral and antitumoral agents.

Process for the preparation of a compound of formula I from a compound of formula II via a compound of formula IV the invention also relates to a compound of formula IV as intermediate in the preparation of a compound of formula I.

Phosphotriester compound of general formula (I); wherein R is a radical - (CH2)n - S - X in which X is a radical (a) or -S-U, Z being O or S, and Y and U denote an alkyl, aryl or osidic radical, optionally substituted in particular by an OH, SH or NH2 group, and n is from 1 to 4, preferably 1 or 2, and Nu is a radical consisting of a biologically active compound residue or the dephosphorylated res...

There are disclosed nucleosides having Formula I: I wherein R is H or acyl. These compounds have anticancer activity.

Methods of immobilizing nucleic acid on a solid surface for us in nucleic acid hybridization assays is disclosed. The methods of the invention comprise reacting a modified nucleic acid strand comprising a variable portion and an anchor portion wherein the variable portion comprises a nucleotide sequence having a selected base sequence and the anchor portion comprises at least one nucleotide base m...

An apparatus for delivering metered quantities of a fluid substance (B) into a container (24A), under the control of a programmable process unit (23), and a weighing device (24). The apparatus comprises a main storage tank (25) to fill by gravity a pressurisable auxiliary vessel (26) connected to the inlet (12) of delivery valves (13, 14, 15) having different flow rates; the process unit (23) is p...

Synthetic glycosaminosyl transferase-V acceptors and inhibitors are disclosed. Minimal trisaccharide inhibitors and acceptors specific for GnT-V, which is associated with the ability of cells to metastasize are useful, in diagnosis and treatment of conditions characterized by metastatic cells.

Compounds of the general formula S-Ar-X in which S is a saccharide residue, Ar is an aryl radical and X is a straight-chain or branched alkyl radical with 2 to 20 carbon atoms, with the proviso that Ar-X must not be a 4-ethylphenyl, 4-isopropylphenyl, 4-sec.-butylphenyl or 4-dodecylphenyl radical when the saccharide is a galactopyranoside residue, are interesting surface-active agents and ...

A compound of the formula (I) wherein R1 and R2 represent respectively hydrogen atom or together form straight or branched alkylidene group of 1-10 carbon atoms, Y represents R3 represents hydrogen atom, C1-10 alkyl group of C1-10 alkoxycarbonyl, R4 and R5 represent respectively hydrogen atom or C1-5 alkyl group, n represents 0 or an integer of 1-10, and m represents an integer of 1-...

A method for the synthesis of a plurality of oligonucleotides comprising the steps of (i) forming a first oligonucleotide on a first cleavable link attached to a solid support; (ii) attaching to the first oligonucleotide a cleavable linker moiety; (iii) forming a second oligonucleotide on the cleavable linker moiety; and (iv) cleaving the first cleavable link and the cleavable linker moiety to giv...

A method of removing uncommitted changes made to stored data by a database management system, wherein the system stores a duplicate copy of data prior to effecting changes to the original copy, and upon failure of the system, or a transaction or transactions effecting the changes replaces the copy containing uncommited changes by the duplicate copy, characterised in that, in the case of failure of...

An aromatic substituted glycoside is disclosed of the formula wherein the configuration of the substituted -OR on the anomeric carbon is alpha, n is an integer of 0 or 1, and R is a substituted aromatic radical selected from the group where R1 through R6 are independently halogen, NO2, SO3H, @OR7, - @-OH, -@-H, O @R7, where R7 is lower alkyl; and includes its stereoisomers, optica...

An improved process suitable for large-scale production of 2',3'-didehydro-3'-deoxythymidine (d4T) and close analogs is disclosed. The improved process yields d4T in high yield and purity without the use of hazardous reactions or reagents and incorporates several process improvements important on a large scale including a novel purification step involving the isolation of a d4T.N-methylpyrrolidino...

The invention provides 5-deoxy-5,5-difluoro derivatives of aminoglycoside antibiotics of neamine, kanamycin A, kanamycin B, gentamicin and seldomycin, each synthesized as a novel compound, and also 1-N-( alpha -hydroxy- omega -aminoalkanoyl) derivatives synthesized from the newly obtained 5-deoxy-5,5-difluorokanamycins A and B and analogs thereof. The 5-deoxy-5,5-difluoro derivatives thus obtained...

Disclosed are methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides. Specifically, in the disclosed methods, sialyltransferase is activated to transfer an analogue of sialic acid, employed as its CMP-nucleotide derivative, to an oligosaccharide glycoside. The analogue of sialic acid and the oligosaccharide employed in this method are selected to be compatible with the ...

A monoclonal antibody which belongs to the subclass IgG3, is reactive with at least one GD3 ganglioside and with 3',8'-LD1 and has cytotoxic activity, which is useful in the treatment of neutroectodermal carcinomas.

The disclosure relates to an apparatus for the ultrasonic sealing of thermoplastic materials and comprises a vibration generator (2) of a so-called giant magnetostrictive powder composite (GMPC) which is secured in a jaw and has been given a cross-sectional area which progressively reduces seen from the anchorage point and whose free end displays a narrow working surface. The vibration generator (...