The present invention refers to a new process for the preparation of azithromycin dihydrochloride, which is a pharmaceutically acceptable salt of the antibiotic azithromycin useful as an antibacterial agent with a broad-spectrum action.

Oligonucleotides, which incorporate 7-deazanucleosides, are useful as antisense sequences to inhibit the function of RNA and DNA.

Oligonucleotide analogs are provided having improved nuclease resistance. Modifications of selected nucleotides through substitutions on the pyrimidine ring are disclosed. Certain preferred embodiments comprise the inclusion of said modified nucleotides at a plurality of sites, especially at the 3' end of a selected oligonucleotide analog.

Antiparasitic avermectin derivatives of formula (I), where the broken line represents an optional bond, R<1> and R<4> being absent when this bond is present, R<1> and R<4> are independently H, OH, halo, oximino, or an organic radical, R<2>, R<6> and R<7> are organic radicals and R<3> is alpha-oleandrosyl or 4'-(alpha-oleandrosyl)-alpha-oleandrosyl optionally substituted at the 4' or 4"-position, a...

2 min -Methylidenepyrimidine nucleoside compounds of the general formula : wherein R<1> stands for amino or hydroxy group; R<2> stands for a halogen or a lower alkyl when R<1> is amino or R<2> stands for an alkyl having 2 to 4 carbon atoms, an alkynyl having 2 to 4 carbon atoms or a haloalkyl when R<1> is hydroxy group; and R<3> stands for hydrogen or a phosphoric acid residue, or salts the...

The invention provides methods for attaching detectable labels to the N7-formyl group, of imidazole ring-opened alkylated purines and purine derivatives, directly, through a linking group, or by subsequent derivatization of a blocking group. The invention provides simple and efficient methods for labeling polynucleotides. In addition, the invention provides derivatized ring-opened alkylated purine...

A golf club head having a body (11) defining a heel (12), toe (13), top wall (14), sole (15) and a front wall defining an upwardly and rearwardly inclined front face (16), the body defining a forwardly extending main recess located rearwardly of the front wall; and the body also defining an undercut recess located directly rearwardly of the front wall and extending outwardly from the main recess t...

A golf club head (10) (e.g. an "iron" club head) has a body (11) defining a heel (12), toe (13), top wall (14), sole (15) and a front wall (17) defining an upwardly and rearwardly inclined front face (16) and rear face. The body has a forwardly extending main recess (21) located rearwardly of the front wall (17) and also an undercut recess (22) located directly rearwardly of the front wall rear fa...

The invention is a welding tool for welding and cutting a tear seal edge into multiple plies of plastic film. The welding tool includes a base and a knife edge on the base. A cross section of the knife edge has three surfaces for engaging the multiple plies of plastic film. The three surfaces at the cross section are a planar cutting surface (41), a planar welding surface (42), and a planar separa...

For many applications the surfaces (6) of rock wool products (1) need to be coated, particularly when used as plaster faced insulating board or as roof insulating board. With industrial scale manufacture difficulties arise in applying the coating (8) in such a way that the open surface structure of the rock wool material remains intact. The invention provides that the aqueous coating material is f...

A golf club head comprising toe and heel portions (32 and 30), a front wall defining a ball-striking face, and top and bottom walls, the bottom wall characterized as having a medial ridge (60), and as forming two shallow recesses (162,164), one recess (164) between the ridge and the heel portion, and the other recess (162) between the ridge and the toe portion, the recesses everywhere spaced rearw...

Method and device for packaging fabric bales, there being used to form a protective wrapping a protective foil, the start of which is inserted into the gusset between the bale and the end-piece of the fabric, and thereafter a rotation of the bale in the winding direction taking place. Subsequently, the protective foil is cut off and fastened to the wrapping. If a foil which is shrinkable under the...

Alpine ski boot including rear support take-up (recovery) means (10) of the upper (3) and tightening means of a collar (4) over a lower leg, consisting of a link (9) forming a double circuit and of a lockable lever/tensioner (11). The flexible link (9) describes a circuit having, as origin, a flange (coupling) (6) of the collar (4) constituting a movable attachment point (12) of one end (9a) of th...

Absorbent structures having a wetlaid fluid acquisition/distribution layer with an average dry density of less than about 0.30 g/cc, an average density upon wetting with 1.0% NaCl aqueous solution of less than about 0.20 g/cc, and an average dry basis weight from about 0.001 to about 0.10 g/cm2; and a fluid storage layer positioned beneath the aquisition/distribution layer comprising at least abou...

A filter element (2) to be installed in a vessel (1) (pressure vessel or - in the case of vacuum systems - open vessel) includes a multiplicity of parallel filtrate channels (5) which are surrounded by filter medium (3). At the lower end, in the installed position, of the filtrate channels (5) is situated a first, transversely running collection channel (6) of smaller cross-section which serves fo...

By the oxidation of olefins having 16 to 70 C atoms by means of chromosulphuric acid in a single- or multi-stage process in at least one reactor having a narrow residence time spectrum, carboxylic acid mixtures can be produced. These can be processed with monoalcohols or polyols such as glycol, glycerol, trimethylolpropane, pentaerythritol or sorbitol to give esters and partial esters or to give m...

PCT No. PCT/EP94/00341 Sec. 371 Date Dec. 19, 1994 Sec. 102(e) Date Dec. 19, 1994 PCT Filed Feb. 7, 1994 PCT Pub. No. WO94/18018 PCT Pub. Date Aug. 18, 1994A valve which includes signal generating means generate a signal representing a pressure drop within a vehicle tire. The valve includes an absolute pressure sensor coupled to measure the pressure within the tire. A microprocessor is provided wh...

Disclosed is an elongated, curved sanitary napkin (10) having elasticized, raised side edges (50,52) along the opposite sides of an absorbent (18). A garment attachment panel (14,16) is secured to the underside of each raised side edge (50,52). A fixed portion (70) of the garment attachment panel (14,16) is bonded flat against each raised side edge (50,52) so that a free portion (72) of each of th...

The gripper (10) has two gripper parts (11, 13), of which the one, first gripper part (11) is pivotable relative to the other, second gripper part (13). To hold a printed product (P), the free ends (12a, 14a) of the two gripper parts (11, 13) interact. The first gripper part (11) is mounted in a bearing part (21) by means of a ball joint (22), said bearing part being seated non-rotatably on a rota...

PCT No. PCT/DE93/00288 Sec. 371 Date Sep. 26, 1994 Sec. 102(e) Date Sep. 26, 1994 PCT Filed Mar. 24, 1993 PCT Pub. No. WO93/20222 PCT Pub. Date Oct. 14, 1993A process for the production of 17 alpha -hydroxy-3-methoxy-8,14-seco-1,3,5 (10),9(11)estratetraen-14-one by fermentation of 3-methoxy-8,14-seco-1,3,5(10),9(11) -estratetraene-14,17-dione with a live culture of Kloeckera magna is described, wh...