PCT No. PCT/FR93/01270 Sec. 371 Date Jun. 21, 1995 Sec. 102(e) Date Jun. 21, 1995 PCT Filed Dec. 20, 1993 PCT Pub. No. WO94/14829 PCT Pub. Date Jul. 7, 1994Compound of the formula (I) in which R' is a hydrogen atom or a radical R and R is an acyl residue. The invention also concerns the use of said compounds in the treatment of cancer and pharmaceutical compositions comprising said compounds. <...

A process for the preparation of 2-amino-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl) adenine (V) is described. The process uses a protected 2,6-di(tri-alkylsilylamino)-9-trialkylsilylpurine (II) which is reacted with protected chlorosugar 2,3,5-tri-O-benzyl-1-chloro-D-arabinofuranose (III) and then the protection groups are removed from the 2 and 6 positions. The process provides a 9-beta-D-ara...

A process is disclosed for preparing alkyl polyglucosides of general formula (I), by reacting an alcohol with a reducing sugar or with an equivalent of the latter, in the presence of a binary catalyst formed by a strong organic acid and a weak, also organic, base, having a Ka comprised within the range of from 10<-><8> to 10<-><1>.

PCT No. PCT/EP93/03404 Sec. 371 Date Oct. 14, 1994 Sec. 102(e) Date Oct. 14, 1994 PCT Filed Dec. 3, 1993 PCT Pub. No. WO94/13570 PCT Pub. Date Jun. 23, 1994A winding bobbin for receiving elongated winding material, in particular metal-containing winding material, comprises a winding core having two flanges arranged thereon and which is preferably made of plastic. At least one flange is removable w...

PCT No. PCT/FR94/00563 Sec. 371 Date Jan. 17, 1996 Sec. 102(e) Date Jan. 17, 1996 PCT Filed May 11, 1994 PCT Pub. No. WO94/26764 PCT Pub. Date Nov. 24, 1994The trister phosphorothioate oligonucleotides disclosed comprise internucleotide concatenations having a P-S- bond protected by a bioreversible grouping (X) in intracellular media.

Rare earth chelate-conjugated oligonucleotides useful in nucleic acid hybridization assays and for generating chelate-labelled probes of any desired sequence are disclosed. The particular class of chelates utilized exhibit an unusually high efficiency of rare earth element capture, correlated with emission of a high level of signal in time-resolved fluorescence spectroscopy compared to other struc...

The invention relates to a process, a combination of means for isolating nucleic acid from a nucleic acid-containing starting material and a testkit in order to amplify the nucleic acid obtained by said process. More in particular, the invention relates to a process and a kit for isolating nucleic acid from a nucleic acid-containing biological material such as whole blood, blood serum, urine, fece...

A process is disclosed for producing particular hydroxyalkyl glucosides in the presence of a binary catalyst.

The present invention provides temperature stable crystalline etoposide 4'-phosphate diethanol solvate, and a process for its preparation.

Disclosed is a process for producing AZT (3'-azido-3'-deoxythymidine) and derivatives thereof. The process makes use of a reduction step wherein a 2'-halo-5'-protected pyrimidinyl 2'-deoxyribonucleoside compound is reduced in an ether, ester, or ketone solvent. Also, the process makes use of a displacement step wherein a 3' alpha -sulfonyl group is displaced with an azido group in the presence of ...

A method for fixing members includes a step of inserting a conductive thermosetting adhesive between the members to be bonded with each other, and a step of flowing a current directly through the conductive thermosetting adhesive so that the adhesive is cured itself due to Joule effect caused by the current flowed through the adhesive.

PROBLEM TO BE SOLVED: To eliminate a surface separation phenomena between a heat sink and a semiconductor package to prevent moisture from penetrating a surface separation part by comprising a first sealed part formed of a liquid epoxy resin containing a large quantity of bonding reinforcing agents and a second sealed part formed of a mold compound. SOLUTION: A first sealed part 6 is formed by har...

PROBLEM TO BE SOLVED: To simplify fabrication of a vertical resonator surface emitting semiconductor laser defined in its polarization direction by constructing at least one reflection mirror between two reflection mirrors with a multi-layered film having a plurality of quantum fine wires extending in one direction parallel to the reflection mirror. SOLUTION: In a surface emitting semiconductor la...

PROBLEM TO BE SOLVED: To control intensity of laser light by providing beam split means for dividing radiation light to a certain part and a remaining part, the regaining part being used as an output light beam, and mounting the beam split means in a package together with a laser and optical sensor means, and further guiding part of the beam to the optical sensor with the aid of one among diffract...

PROBLEM TO BE SOLVED: To encode an audio signal in real time with the small hardware. SOLUTION: A spectral signal component of an input signal is divided into coding units being a unit of coding, an estimated value of the required number of bits for each coding unit is calculated in the step ST 102 and based on the estimated value in the required number of bits, total number of bits required for c...

PROBLEM TO BE SOLVED: To provide a device configuration suitable for digital video/audio signal broadcast system such as a near-video-on-demand(NVOD) device. SOLUTION: An NVOD device 1 is composed of a compilation part 100, playout part 200, transmission part 300 and subscriber part 400. The compilation part 100 stores video/audio signals for several weeks or several months edited by reproducing a...

PROBLEM TO BE SOLVED: To realize a linear motor which can provide a stable drive force and a smooth movement and which is small in size and easy to manufacture. SOLUTION: An expansion vibration and a standing wave are simultaneously generated by the laminated piezoelectric devices 54a of a piezoelectric transducer 54. The guide 52 in a linear guide is driven to moved by sliding protrusions 54b whi...

A method and apparatus for selecting a destination in a vehicle navigation system are described. The vehicle navigation system includes a display and a selection control. A first destination is selected from a primary list of destinations in response to a selection signal generated by the selection control. The first destination is placed on a secondary list of destinations in response to its sele...

A multifocal birefringent lens system is described together with applications of the lens system such as ophthalmic lenses (including those of the intraocular, contact and spectacle type) and optical instruments and devices including photographic cameras, telescopes, microscopes, copiers, spectrographic instruments, etc.

A temperature-controllable roll 1 serves as a heat-sealing tool on the circumferential surface of which a number of plastics film webs 14, 15, 16 are heat-sealed to one another with the application of pressure and heat. The plastics film webs travel at equal or different distances from one another onto the circumferential surface of the roll 1 and are guided via pressure rolls 2, 3, ... 7. The sai...