Several diterpene glycosides (e.g., rubusoside, rebaudioside, steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including but not limited to, paclitaxel, camptothecin, curcumin, tanshinone HA, capsaicin, cyclosporine, erythromycin, nystatin, itraconazole, and celecoxib. The use of the diterpene glycoside ...

A solid pharmaceutical composition suitable for oral administration, comprising: (a) a S1P receptor agonist; and (b) a sugar alcohol.

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.

Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, reti...

A method and a device for detection of physical or approximately physical bottom contact for objects, for instance fishing tackles, which are dragged closely above or on a sea bottom, said method consisting of sensoring an alteration of a force acting on a tension sensor ( 4 ) as a consequence of a mass ( 7 ) coupled to the tension sensor ( 4 ) coming into physical contact with the bottom, said al...

The invention relates to a process for isolating edible protein from animal muscle by solubilizing the protein in an alkaline aqueous solution.

The present invention relates to a pallet made from recycled paper or plastic material, rectangular in shape, with loading surface (9) provided with reinforcing indentations (7) which run in the same diagonal direction at opposite corners, but do not generally combine (2a, 2b, 2c, 2d). The indentations at adjacent corners have orthogonal direction with respect to each other and may combine (8). Ad...

The present invention provides an apparatus and a method for making large objects from fibrous slurry or paper pulp in water by using mating molds and hot air drying. The apparatus and the method of the present invention use robots with 3-dimentional freedom of rotation to transfer moulds from slurry tanks for draining and to transport the objects to drying units. A set of robots with mating mold ...

Two polymorphic forms of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid] calcium salt, processes for making them and their use as HMG Co-A reductase inhibitors are described.

Compounds of Formula I: in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

The invention relates to a dosage regimen for emergency contraception, to pharmaceutical compositions of the same purpose, to the use of levenorgestrel for the manufacture of pharmaceutical compositions for the same purpose, as well as to the manufacturing process of these pharmaceutical compositions. According to the invention the emergency contraception carried out by the use of levonorgestrel a...

The automatic-transition, collapsible-rhombus differential has an external pulley and internally a rhombus-shaped movable-part assembly, a supplementary fifth rod and two similar cranks. Each crank ends to journals, wherein one journal is a shaft receptacle and the other is rotatable. The rotatable journals belong to the hinges of a diagonal of the rhombus-shaped movable-part assembly. The journal...

The present invention provides a compound having a superior Smo inhibitory activity and lower toxicity, which is sufficiently satisfactory as a pharmaceutical product. The present invention provides a compound represented by the formula wherein ring A is 5- to 7-membered ring optionally having substituent(s), where substituents are optionally bonded to each other to form a ring; X is O, S or NR1 (...

La presente invención se relaciona con derivados de azetidina y ciclobutano, así como sus composiciones, métodos de uso, y procesos para su preparación, los cuales son inhibidores de JAK útiles en el tratamiento de enfermedades asociadas a JAK incluyendo, por ejemplo, desórdenes inflamatorios y autoinmunes, así como cáncer.; The present invention relates to azetidine and cyclobutane derivatives, a...

Compuestos de arilo de anillo condensado de fórmula (l) y uso de los mismos como producto agroquímico para combatir organismos nocivos en la que (X)mQ, A, R1,(Y) y el agrupamiento -w1-w2-w3-w4- son tal como se definen en el presente documento.; Condensed-ring aryl compounds of formula (I) and use of the same as a agrochemical for controlling noxious organisms wherein (X)mQ, A, R1, (Y)n and the gro...

La invención se refiere a nuevos productos de fórmula (l): en los que Het representa un heterociclo opcionalmente sustituido por uno o varios radicales R1 o Rl, R se elige del grupo constituido por Fórmula (11) con R1 y/o Rl, elegidos entre: H, halógeno, CF3, nitro, ciano, alquilo, hidroxi, mercapto, amino, alquilamino, dialquilamino, alcoxi, fenilalcoxi, alquiltio, carboxi libre o esterificado po...

El procedimiento de cierre extremo de envolturas tubulares plisadas comprende el desplisado de una porción terminal de la envoltura tubular en la dirección del eje del bastón, volteo de la porción terminal desplisada para su introducción en el interior de la envoltura, sujeción desde el interior de la envoltura de la porción terminal desplisada, girado de la porción terminal y aplastamiento de la ...