The invention relates to linear and cyclic peptide and pseudopeptide compounds useful as analgesics, pharmaceutical compositions comprising such compounds, the use of the compounds and the compositions in the treatment of pain, and commercial packages containing such compounds and compositions.

New starting materials and chemical processes will be used to make fluorinated poly(para-xylylenes) (F-PPX) and fluorinated poly(para-fluoroxylylenes) (F-PPFX). The processes will use some very low cost and readily available starting materials, catalysts, chemical reactors, transport polymerization (TP) systems, and chemical vapor deposition (CVD) systems commonly used for making F-PPX. New TP and...

High-quality composite printing elements are prepared without the need for precise registration of constituent photocurable elements by disposing at least one photocurable element, and preferably a plurality of photocurable elements, upon a surface of a printing element in approximate register and then transferring a computer-generated negative onto a surface of the elements.

The synthesis of liquid molding resins derived from plant oils that are capable of curing to high modulus thermosetting polymers and composites is described in this invention. The resins described resemble the unsaturated polyester, vinyl ester and epoxy resins presently used as the polymer matrix material in high performance glass, carbon, aramid and natural fiber reinforced composite materials. ...

An automated injection module is comprised of a housing, a piston drug capsule disposed within the housing, a piston core including a puncture seal membrane defining a reservoir for holding a drug between the puncture seal membrane and the piston drug capsule, an injection device having at least one sharp end for puncturing the puncture seal upon activation of the device, an end cap on a distal en...

PURPOSE:To efficiently crystallize large liquid crystal of amino acid or nucleic acid. CONSTITUTION:A solution of amino acid or nucleic acid is fed to a crystallizing tank 1 while stirring. Slurry of crystallized crystal is sent to a liquid cyclone 4. The slurry of crystal sent to the liquid cyclone 4 is divided into a flow containing a large amount of coarse crystal and a flow containing a large ...

This invention relates to a novel chartreusin derivative of the general formula (I): (I) and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation and the site of drug administration are different. This invention further relates to a antitumorous composition containing the above-me...

The invention relates to compounds of the formula Iand to pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I, methods of using said compounds of formula I in the treatment of infections, and methods of preparing said compounds of formula I.

The invention relates to compounds of formula (I) and to pharmaceutically acceptable salts thereof, wherein R<1>, R<2>, R<3>, R<4> and X are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula (I), methods of using said compounds of formula (I) in the treatment of infections, and methods of preparing said compounds of formula (I).

A portable computer arranged to rest comfortably in the hand has a small display screen. Accelerometers capable of detecting movement of the pen with respect to gravity provide input to a microcontroller which selects a response from a number of viewing modes. The pen may be held in either hand and the output message to the screen will be oriented according to the location of the pen. Full persona...

This instrumentation comprises valves (2) for shifting aside tissues and vessels, pins for fixing each valve (2) to the spine, each valve (2) comprising for this purpose sleeves (6) in which the pin (5) is slidable; the instrumentation further comprises, for each valve (2), an articulated device (7) comprising a clamp (12) for clamping a rod (13) fixed to the valve (2); the clamp (12) may be artic...

Novel nucleotide compounds represented by general formula (I) or (II) and a method of synthesizing oligonucleotides, in particular, di- to hexameric block compounds therefrom, wherein B represents a nucleic acid base protected, if necessary, with a suitable protective group; R represents a hydroxy-protecting group; X represents hydrogen, optionally protected hydroxy, or alkoxy; and Y1 and Y2 may b...

Polymers are randomly labelled with labelling groups such as fluorophores, by a process of creating free radicals on the polymer in the presence of a stable free radical, such as an aminooxyl compound, so that the stable free radical group bonds to the polymer in random fashion. Labelling groups such as fluorophores are attached to the stable free radical groups, before or after they are attached ...

Erythromycin A derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof.

An erythromycin A derivative represented by the formula:wherein n is an integer of from 1 to 8, R1 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R2 is a pyridylmethyl group, a quinolylmethyl group, a pyridylsulfonyl group or quinolylsulfonyl group, R3 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a cinnamyl group, R4 is a cladinosyloxy group or a group represe...

An erythromycin A derivative represented by formula (I) wherein n is an integer of 1 to 7, R<1> is a group represented by the formula: -SO2N(-R<7>)-R<8> or N-(R<10>)SO2R<9>, R<2> is a hydrogen atom, an alkyl group or a cinnamyl group, R<3> is a group represented by the formula: -OCO-CH2-R<11>, -OCO-R<11>, -OCO-NH-R<11>, -O-R<11> or -OCO-O-R<11>, R<4> is a hydrogen atom, or R<3> and R<4> together ...

An erythromycin A derivative represented by formula (I), wherein n is an integer of 1 to 7, R<1> is a hydrogen atom or an alkyl group, R<2> is a quinolyl group, a pyrazinyl group, a benzimidazolyl group, a thiazolyl group, a pyridyl group, a pyrimidyl group, a purinyl group, a triazinyl group, a phenyl group or a naphthyl group, R<3> is a hydrogen atom, an alkyl group or a cinnamyl group, R<4> is ...

Novel 6,11-bridged erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II); compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier; a method for treating bacterial infections by administering to a mammal a pharmaceutical compo...

Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutic...

PURPOSE:To monitor the irradiated part with laser beam by judging whether laser beam is being emitted, and selecting a visible beam of color light according to the result from judging, and casting it to the target for irradiation. CONSTITUTION:Power source 46 is put on in the current fed condition of a pump driver circuit 11, and when a switch SW1 is opened, a driver circuit 45 does not give volta...