Composed element comprising at least two panel-shaped elements (2-3), which each have an edge zone (4-5) in which coupling means (6-7) are present in the form of a profiled part (8-9) respectively extending in the longitudinal direction of the respective edge zone (4-5), as well as each comprise an end face (10-11) extending transversely to the respective edge zone (4-5), wherein said profiled par...

The present invention relates to sustained release formulations comprising as active ingredient octreotide or a pharmaceutically-acceptable salt thereof and two different linear polylactide-co-glycolide polymers (PLGAs).

Disclosed herein are processes for preparing glucopyranosyloxypyrazole derivatives and pyrazole intermediates of the same. In particular, the present invention relates to glucopyranosyloxypyrazole derivatives having SGLT2 inhibitory activity and processes and intermediates for preparing the same.

A synthesis approach providing an early ring attachment via a bromination to compound l-l yielding compound II-Il, whereby a final product such as AA can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.

The invention relates to compounds of formula (I) where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula (I) are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing...

A foamed polyolefin composition comprising (all percent amounts being by weight): A)50%-90% of a polypropylene component; and B)10%-50% of a copolymer component of ethylene and at least one C3 -C10 α-olefin, the copolymer containing from 15% to 50% of ethylene, and optionally minor amounts of a diene; the said amounts of (A) and (B) being referred to the total weight of (A) and (B); said compositi...

Method and system for generating output signals for reproduction by two physical speakers in response to input audio signals indicative of sound from multiple source locations including at least two rear locations. Typically, the input signals are indicative of sound from three front locations and two rear locations (left and right surround sources). A virtualizer generates left and right surround...

The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given...

Optical elements, color combiners using the optical elements, and image projectors using the color combiners are described. The optical elements can be configured as color combiners that receive different wavelength spectrums of light and produce a combined light output that includes the different wavelength spectrums of light. The optical elements include a wavelength selective dichroic mirror th...

High molecular weight naphthenic tetra-acids are added to a base crude oil to prevent and/or reduce fouling of crude oil refinery equipment. The method includes adding an effective amount of a high molecular weight naphthenic tetra-acid to the base crude oil to form a crude oil mixture and feeding the crude oil mixture to a crude oil refinery component. Particularly, the high molecular weight naph...

A reverse phase chromatographic media selected from media of the formula: [X-C6H4-(O)m-(CH2)n]q-Z and hydrophobic end-capped media of said formula, wherein n is a numeral of from 1 to 4, and m is 0 or 1, and when m is 1 X is selected from the group H, an alkyl group having from 1 to 6 carbon atoms and a phenyl group, and when m is 0 then X is selected from an alkoxy group having from 1 to 6 carbon...

The present invention relates to Tumor Necrosis Factor-alpha (TNF-alpha or TNF-α) inhibiting peptides and process for the preparation thereof. The present invention further relates to a pharmaceutical composition comprising TNF-alpha inhibiting peptides of the present invention and uses thereof in treating TNF - alpha mediated inflammatory disorders.

The present invention relates to a device for encapsulating a closed flat carrier with electronic components, comprising a first mould part with a first mould cavity and a second mould part with a second mould cavity which is adapted to connect to the second side of the carrier. The invention also relates to a method for at least partially encapsulating a closed flat carrier with electronic compon...

Disclosed are personal care compositions for use on hair, skin, oral cavity, throat and other mucosal surfaces containing a flavor/perfume system comprising one or more coolants, wherein the pleasant cool and refreshing sensation provided by the coolant is enhanced in terms of quicker onset, greater intensity or impact and/or longer duration, thereby improving appeal and acceptability of the compo...

A reciprocally-cycled, externally-powered weapon may include a rotative driver connected via a crank and connecting rod to the operating group of the weapon. The connecting rod may be connected to a pinion that meshes with a translating rack and a stationary rack. The translating rack may be connected to the operating group, and the stationary rack may be fixed to the receiver of the weapon. The e...

An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular dibasic calcium phosphate based excipient is provided. The improved excipient comprises dibasic calcium phosphate, a binder and a disintegrant, and is formed by spraying a homogeneous slurry of the components. The improved excipient provides enhanced flowability/good flow properties,...

The invention provides a lubricating composition comprising an oil of lubricating viscosity and an amine-functionalised additive, wherein the amine-functionalised additive is derived from an amine having at least 3 aromatic groups, at least one -NH2 functional group, and at least 2 secondary or tertiary amino groups. The invention further provides for the additive to have dispersant and/or dispers...

Novel administration form of osteogenic protein complexes [000410] The invention relates to osteogenic compositions composed of acoprecipitate that contains at least one insoluble calcium salt and at least one complex between an osteogenic protein and a polysaccharide, said coprecipitate being in divided form The invention also relates to kits for performing the invention. [000411] The invention a...

Reduced-pressure treatment systems and methods are disclosed that employ debridement mechanisms to remove unwanted tissue. In one instance, a reduced-pressure treatment system for treating a tissue site on a patient includes a manifold member for distributing reduced pressure to the tissue site, a support member for disposing proximate the tissue site and the manifold, and a debridement mechanism ...

Provided is a procatalyst composition containing a multiple internal electron donor with at least two components, one of which is a silyl ester. The other component of the mixed internal electron donor may be an electron donor component. The electron donor component may be an aromatic acid ester, a di-ether, and combinations thereof. Catalyst compositions containing the multiple internal electron ...