Dermatological topical compositions based on liquid crystals as vehicle, containing, as the active substance, urea, bifonazole, sodium lactate, organic and inorganic filters, sodium gluconate, a disinfectant and adjuvants and a method of preparation, comprising forming a system of liquid crystals in an oil-in-water emulsion with an anisotropic lamellar phase such that the layer of the water phase ...

Compounds of general formula Iwherein X is a single bond, -O-, C-C4-alkylene, or an alkylene bridge having 1 to 8 carbon atoms which may be branched or unbranched and optionally have one or two oxygen atom(s) anywhere in the bridge; R1 is hydrogen, methyl, ethyl, or phenyl; R2 is hydrogen or methyl; R3 is hydrogen, fluorine, chlorine, bromine, hydroxy, methyl, or methoxy; R4 is hydrogen, methyl, o...

A plug connection with an automatically actuated outlet shut-off includes a cylindrical receptacle housing with an opening for inserting a tubular plug-in part that is provided with a circumferential holding rib which can be engaged in a locking element arranged in the inserting region of the receptacle housing. Ring seals for sealing the annular gap between the inner wall of the receptacle housin...

The invention concerns a clutch mechanism comprising a wear take-up device with a ramp (32) ring (330) coupled in rotation into axial mobility with an intermediate part (310) equipped with a tooting (31) engaged in an endless screw (36) integral with a cover. The invention is applicable to a motor vehicle.

The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important "housekeeping" enzyme in many tissues, including the gastrointesti...

The potent reverse transcriptase inhibitor Efavirenz is produced in crystalline form. Crystalline Efavirenz exists in several physical forms which are designated Forms 1, 2, 3, 4 and 5 and are characterized by x-ray powder diffraction and differential scanning calorimetry. Pharmaceutical compositions and methods are useful for the treatment of the human immunodeficiency virus (HIV).

The use of compounds of the formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs:wherein:Ring C is phenyl or a carbon linked heteroaryl ring substituted as defmed within;R1 is an ortho substituent as defined within;n is 1 or 2;A-B is a linking group as defi...

Pectin degrading enzymes derived from or endogenous to Bacillus licheniformis or other Bacillus species which are at least 99 % homologous to Bacillus Licheniformis based on aligned 16S rDNA sequences have optimum activity at pH higher than 8. The pectin degrading enzymes belong to the enzyme classes pectate lyases (EC 4.2.2.2), pectin lyases (EC 4.2.2.10) and polygalacturonases (EC 3.2.1.15) and ...

The invention relates to an aluminium alloy sheet or strip with a thickness of between 1 and 5 mm which is intended for the production of stamped and bent parts having a small bend radius, the composition ( % by weight) of said alloy comprising: Si<0.4, Fe<0.4, Cu<0.4, Mn + Cr:0.3-0.7, Mg:4-5.5, Zn<1, other elements <0.05 each and <0.15 in total, and the remainder aluminium. Moreover, the inventiv...

A tire having a radial carcass reinforcement of low H/S ratio, at least one bead provided with an axially outer protuberance, the maximum axial width of which is greater than the space taken up by the rim, characterized in that the protuberance is provided with incisions of a width other than zero, of a depth of at most 5 mm and arranged circumferentially parallel to each other.

The invention relates to a process for the preparation of spiro[cis-4-(beta-hydroxyethyloxy)cyclohexane-[3H]indol]-2'[1'H]-one derivatives of the formula (I) wherein R1 and R2 are as defined herein, by reduction of a dispiro[(1,3-dioxolane)-2,4'-cyclohexane-1'3'-[3H]indol]-2''[1''H]-one derivative of general formula (II), wherein R1 and R2 are as defined herein, which comprises carrying out the re...

There is described a process for the preparation of 1-phenylpyrazoline-3-carboxylic acid derivatives of the formula III by means of base-catalyzed reaction of hydrazones of the formula I with olefins of the formula II where Ph, R1, R2, R3, X and Y have the following meanings: Ph is optionally substituted phenyl, R1 is hydrogen or alkyl, R2 and R3 independently of one another are hydrogen, halogen,...

A filter that includes a first electret filter layer through which an airstream first passes before encountering a second electret filter layer. The first filter layer exhibits nondecreasing removal efficiency and removes a majority of a challenge aerosol; whereas the second layer exhibits decreasing removal efficiency and has an initial quality factor greater than the first layer. Together, the f...

The invention relates to a process for the preparation of spiro [(4-cyclohexanone)-[3H]indol]-2'[1'H]-one derivatives of general formula I-wherein R1 and R2 independently stand for hydrogen, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4polyfluoroalkyl, C1-4polyfluoroalkoxy, C3-7cycloalkyloxy, C3-7cycloalkylthio, phenoxy, benzyloxy or nitro group-, characterized by reacting an indolin-2-one derivative...

A device for mixing a flowable or pourable medium has a container for receiving the medium and a rotatable shaft having radially projecting support arms and rotatable in a direction of rotation. Mixing elements are connected to the radially projecting support arms. The mixing elements are tubular and formed as coil-shaped spirals conically shaped at least across a partial length of the coil-shaped...

Filtering device (1) consists of several filter elements (4) separated from each other which form filter modules (3) and are arrange in a container (2) containing contaminated liquid. The filter modules form a hollow chamber (14) which is connected to the container on one side via a suction opening and closed on the other side by a supporting plate (6). The hollow chamber interacts with a flow mem...

Microcapsules formed from an aminoplast shell wall and an encapsulated ingredient or ingredients enclosed within the wall in which the wall contains a base-cleavable ester moiety. These capsules have been found to be sensitive to the presence of base such that in the presence of base, the capsule walls are relatively quickly disintegrated or degraded so as to produce a relatively quick release of ...

A sealing material for a thermoplastic packaging film for applications such as meat, poultry and sausage packages that have to be subject to moderate heat treatments common in processes such as pasteurization or sterilization. The sealing material includes a composition of a copolymer of ethylene and an alpha , beta -unsaturated C3-C8 carboxylic acid, optionally neutralized and optionally contain...

The invention relates to antifreeze concentrates which are based on alkylene glycols or derivatives thereof or on glycerin, containing 0.05 to 10 wt. % of one or more cathoxylic acid amides and/or sulfonic acid amides in relation to the total quantity of concentrate.

Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of the formula: wherein Y is a radical of the formulae II or III: in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.