Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in ...

Subject of the invention is an information provider on the water level inside the washing machine or dishwasher based on transforming induction into an electrical signal for activating the actuator. The electronic unit (5) which enables the specified transformation is represented according to the invention by a splashed contact lamella equipped with electronic components. On the side of the connec...

The present invention refers to biologically pure cultures of two strains of Bifidobacterium Longum named W11 and W11a and deposited at the Belgian Coordinated Collections of Microorganisms (BCCM) that has registered them under the accession numbers LMG P-21586 and LMG P-21587, to their use as probiotics within preparations of pharmaceutical or alimentary type and to the preparations of pharmaceut...

Derivat anhidriranog kristaliničnog azido citozinhemisulfataOvaj izum odnosi se na hemisulfatnu sol 1-[4(S)-azido-2(S),3(R)-dihidroksi-4-(hidroksimetil)-1(R)-ciklopentil]citozina (1a) s poboljšanom stabilnošću i fizičkim svojstvima koja pospješuju proizvodnju, održavanje i formulaciju (I) i njegovih polimorfnih kristaliničnih oblika.; The present invention relates to the hemisulfate salt of 4-amin...

A multi-valent vaccine composition is described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide of H. influenzae b.

An absorbent article that has a thin, conformable absorbent core where the core has at least two layers, both of which are substantially free of cellulosic fibers is described. The first layer is intended to provide storage for the majority of acquired fluids and has an AAP of at least about 20 g/g and the second layer, which provides temporary capacity for the bulk of the acquired fluid and perma...

The invention relates to compounds of Formula (IIf) or a salt or solvate thereof, wherein R<3>, Het, X and Z<1> are as described in the specification, pharmaceutical compositions containing them, their use in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes, and methods for their preparation.

5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, hydrochloride monohydrate characterised in that it: (i) provides an infra red spectrum containing peaks at 3358, 2764, 1245, 833 and 760 cm<-1>; and/or (ii) provides an X-ray powder diffraction (XRPD) pattern containing peaks at 15.0, 17.7, 23.0, 30.0 and 31.4 DEG 2 theta ; a process for preparing such a compound, a pharma...

The invention relates to a hydroxamate composition for collection of minerals by froth flotation, the composition including an aqueous mixture of hydroxamate wherein the pH of the composition is at least 11 and a method of collecting mineral values from an aqueous ore slurry by froth flotation.

Opisani su mobilni terminal i metoda za upotrebu u sustavu bežične komunikacije u svrhu omogućavanja prijelaza mobilnog terminala u dvojni način radau kojem su paketno komutirana veza i linijski komutirana veza korištene zajedno, iz jednostrukog načina rada u kojem se prenose paketi. Paketno pridijeljeni kontrolni kanal koristi se za prijenos poruke kontrole radio veze ili kontrole višestrukog pri...

Synergistic combination of a selective and specific sinus node If current inhibitor (I) and a calcium inhibitor (II) is new. An independent claim is included for pharmaceutical compositions comprising the combination optionally in combination with excipients. - ACTIVITY : Antianginal; Cardiant; Antiarrhythmic; Vasotropic. - MECHANISM OF ACTION : Sinus node If current inhibitor; Calcium inhibitor; ...

This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n—-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl),...

Antifungalni sastav premaza za nokte s dvostrukomulogom i postupak upotrebe za poboljšanje ili prevenciju gljivične infekcije noktiju, i onikomikozaposebno, je ovdje obuhvaćeno. Primjeri sastava u obliku tip jedan premaz i tip dva premaza prikladni za dnevni fungicidalni režim su prikazani. Preferirani antifungalni sastav premaza za nokte sadržiučinkovitu količinu antifungalnog sredstva, količinu ...

Amidas sustituidas con heteroarilo que comprenden un grupo enlazador saturado, y su use como agentes farmaceuticos La presente invencion se refiere a N-alquilamidas de formula I, en la que A, Het, X, R1, R2 y R3 tienen los significados indicados en las reivindicaciones, que modulan la transcripcion de la oxido nitrico (NO) sintasa endotelial y son compuestos farmacologicamente activos valiosos. Es...

La presente invencion proporciona compuestos de la fórmula I: en los que R' es un grupo alquilo, fenilo, heterociclilo, cicloalquilo, alcoxi, ester, amino o amida; R2 es un grupo fenilo, heterociclilo, alquilo, cicloalquilo o cicloalquilalquilo; R3 es un grupo alquilo, cicloalquilo, cicloalquilalquilo, amino o heterociclilo; R4 y R5 son hidrogeno o alquilo o forman un anillo cicloalquilo; A es 0 o...

Un amortiguador (1.201) que comprende una combinación de resorte (17,18) que posee un primer y segundo elemento de resorte (17, 18) con capacidad para almacenar energia de las vibraciones del vehiculo, dicho primer y segundo elemento de resorte (17, 18) dispuestos operativamente para compartir la carga a consecuencia de vibraciones inducidas por el camino y las tensiones de corte resultantes de la...

La invencion describe compuestos de la formula general o las sales farmaceuticamente aceptables de los mismos, en la que R1, R2, R4 y R5 tienen los significados definidos en la descripcion, un proceso para su obtencion, medicamentos que los contienen asi como el use de estos compuestos coma agentes farmaceuticamente activos. Estos compuestos presentan actividad como agentes antiproliferante y pued...

La presente invencion se refiere a moduladores no esteroides de receptores de progesterona de la formula general I, a su uso para preparar medicamentos, asi como a las composiciones farmaceuticas que contienen estos compuestos. Los compuestos segun la invencion son apropiados para la terapia y la prevencion de enfermedades ginecologicas tales como endometriosis, leiomiomas del utero, hemorragias d...

La invención se refiere a derivados de isoquinolina sustituidos en posicion 6 con piperidinilo de la formula (I) utiles para el tratamiento y/o prevención de enfermedades asociadas con Rho-cinasa y/o la fosforilación mediada por Rho-cinasa de la fosfatasa de la cadena ligera de miosina, y a composiciones que contienen tales compuestos.; The invention relates to 6-piperidinyl-substituted isoquinoli...

La presente invencion se refiere a moduladores no esteroides del receptor de progesterona de la formula general I, a su use para la preparacion de medicamentos, asi como a las composiciones farmaceuticas que contienen estos compuestos. Los compuestos segun la invencion son apropiados para la terapia y la prevencion de enfermedades ginecologicas tales como endometriosis, leiomiomas de utero, hemorr...