The instant invention provides soluble fusion protein complexes and IL- 15 variants that have therapeutic and diagnostic use, and methods for making thesuch proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL- 15 variants of the invention.

A capacitance-to-digital (CD) modulator converts capacitance of a differential pressure sensor to a pulse code modulation output signal. The first stage of the CD modulator is a sigma-delta integrator having an auto-zero capacitor connected between an integrator input node and an amplifier input. During an auto-zero phase, a feedback capacitor is connected between the amplifier input and output, a...

Torrefacción de biomasa lignocelulósica utilizando un recipiente del reactor que tiene bandejas apiladas; alimentación continua de la biomasa a la entrada superior del recipiente, depositado en una bandeja superior de la pluralidad de bandejas apiladas verticalmente. Calentamiento y secado de la biomasa utilizando un gas no oxidante, al menos a 20 bar gauge (barg) y 200ºC, inyectado en el recipien...

One object of the present invention is an architecture for the support of CS domain services over a Packet only mobile system such as the Evolved Packet System access, in a mobile communication system comprising an Evolved Packet System (EPS) and a CS domain in turn comprising at last one Mobile Switching Center MSC, said architecture comprising at least one Interworking Function IWF, such that IW...

The invention relates to an adjustable stand suitable for supporting an audio speaker and comprising: a base having an upright bearing; a tilt barrel mounted on the upright bearing for adjustable rotation about its own axis; two supporting rods, each supporting rod being mounted on the tilt barrel generally perpendicular to the tilt barrel axis and adapted for movement sideways along the tilt barr...

The present invention provides a new method of ameliorating and/or treating enteritis induced by radiation therapy, alone or in combination with other therapies, for the treatment of, for example, gastrointestinal malignancies, including colorectal, appendiceal, anal, or small bowel cancers; urogenital malignancies, including prostate, ladder, testicular, or penile cancers; gynecologic malignancie...

The cage (10) holds rollers (20) in place without external support. The cage is made up of steel and has a trapezoidal cross-sectional area with a pitch equivalent to two rollers and faces outward. The cage is built in such a way that it is free from deformation or ripping and direct contact of two neighboring rollers is avoided.

The invention relates to a self-adhesive protective film, in particular for temporarily protecting freshly painted surfaces of vehicles such as automobiles and freshly painted vehicle parts, having a carrier made of a thermoplastic film, preferably of polyolefins, coated on one side by a polyacrylate self-adhesive mass in the form of a dried polymer dispersion, wherein the acrylate polymer is made...

The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (DAMPs).; La présente invention a pour objet général des variantes de la chaperonine...

A transistor includes a substrate, a well formed in the substrate, a drain including a first impurity region implanted in the well, a source including a second impurity region implanted in the well and spaced apart from the first impurity region, a channel for current flow from the drain to the source, and a gate to control a depletion region between the source and the drain The channel has an int...

Multimeric fusion proteins of an Ig-like domain of Flt-1 are rendered functional by inclusion of a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins can be used therapeutically to block neovascularization in individuals with pathological conditions related to neovascularization. Such conditions include age-related macular degeneration, cancer, psoria...

A method for manufacturing a monolithic hollow body (1) by means of a casting or injection moulding process, the manufacturing method contemplating the steps of : producing at least one lost ceramic core (2) that reproduces the shape of at least one internal cavity (3) of the hollow body (1), introducing the ceramic core (2) inside a first mould (4) that reproduces in negative the external shape o...

Method for dyeing a substrate prepared by curing a polymerizable composition comprising one monomer containing one episulfide group, said method comprising: - providing a dye solution comprising a dye and a carrier in a solvent, the carrier being chosen from the compounds represented by the following formulae (1) and (2): formula (1) : wherein R1, R2, R3 and R4 are each selected from the group con...

The invention relates to the mast-hydraulic cylinder construction (4, 5) of a two or multiple-stage forklift mast. The substantially vertical beams (4, 5) and cylinder liners (6) of the solid mast structure form an integrated structure (4, 5), in which the cylinder liners (6) consist of ducts integrated within the beams (4, 5), with the mass centre of the cross-section of the integrated structures...

Provided are a porous polyurea body and a method for producing same. The porous polyurea body is produced by polymerizing and cross-linking tetra(4-aminophenyl)methane and a monomer having 2 to 4 isocyanate groups. The method for producing a porous polyurea body comprises: a step of mixing an organic solution in which tetra(4-aminophenyl)methane is dissolved, and an organic solution in which a mon...

The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of A² in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease. Preferred agents including N-terminal fragments of ...