For the purpose of determining whether or not the activation of hepatic NF-kB is involved in the onset of metastatic tumors, a liver metastatic model induced in the spleen is used. When IKKss is lacked in both hepatocytes and hematopoietically-derived cells, the onset of tumors is remarkably decreased. A tumor cell activates an adjacent bone marrow cell (Kupffer cell) to produce a mitogen such as ...

The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with bendamustine for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody and bendamustine.

The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with fludarabine and/or mitoxantrone for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody with fludarabine and/or mitoxantrone.

The present disclosure provides isolated antibodies, particularly human antibodies, or antigen binding portions thereof, that bind to osteopontin with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical ...

The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

A nanoparticle delivery vehicle includes a nanoparticle, an active compound, and a phosphodiester moiety connecting the nanoparticle and the active compound and forms a prodrug. The nanoparticle delivery vehicle achieves the function of increasing hydrophilicity of the active compound and specificity against tumor cells. Advantages of the nanoparticle material include biocompatibility, magnetism a...

This present disclosure relates to pharmaceutical compositions for treating tumors using a polymeric micelle encapsulating an anti-tumor drug. The polymeric micelle comprises block copolymers comprising at least one hydrophilic block, at least one hydrophobic block, and at least one zwitterion. The present disclosure also relates to methods of enhancing the solubility of such drugs, methods of inc...

The invention relates to a binding agent to which is attached at least one cryptophycin derivative of formula (I): in which: R1 represents a halogen atom and R2 represents a group -OH, an acyl group derived from an amino acid AA or a group (C1-C4)alkanoyloxy; or alternatively R1 and R2 together form an epoxide unit; AA denotes a natural or unnatural amino acid; R3 represents a group (C1-C6)alkyl; ...

The present invention provides a ligand of formula (I): the definitions of the substituted groups in formula (I) are defined as set forth in the specification and claim. The present invention also provides a stable metal complex for preparing a blood pool contrast agent or a targeting contrast agent.

A ligand of a formula (I): X represents a single bond, methylene, 1, 1-cyclobutylene, 1, 1-cyclopentylene or 1, 1-cyclohexylene; each of A1, A2 and A3 represents hydrogen, a C1 to C3 alkyl group, a C1 to C3 phenylalkyl group, a C1 to C3 methoxyphenylalkyl group, diphenylmethyl or a C1 to C3 isothiocyanato phenylalkyl group; and R represents an aromatic ring, which may be chelated with a copper ion...

The present invention provides an externally-used preparation based on nitrogen monoxide for curing surrounding blood vessel lesion of diabetes and its preparation method, which uses the nitrate or the plant extract of nitrate as the nitrogen agent of the raw material and uses the organic acid or inorganic acid as the acid agent of the raw material. When the two agents jointly acts on the illness ...

The present invention relates to an oil-in-water type emulsion composition and a sun-care cosmetic cosmetic material, wherein the oil-in-water type emulsion composition is characterized by containing the following (a)-(j): (a) Octocrylene, (b) bis-ethylhexyloxyphenol methoxyphenyl triazine, (c) diethylamino hydroxybenzoyl hexyl benzoate, (d) 4-tert-butyl-4'-methoxydibenzoyl methane, (e) water-solu...

Disclosed is a skin cosmetic in which the emulsion stability can be ensured even when the skin cosmetic is prepared by adding a volatile hydrocarbon oil to a water-in-oil-type emulsion composition containing a non-volatile silicone oil, and which has an excellent non-oily sensation upon application. Specifically disclosed is a water-in-oil-type emulsion skin cosmetic which is characterized by comp...

Disclosed is an external preparation for skin that has a pH of 3.0-6.0 and that combines (A) a higher alcohol, (B) 0.01-5 mass% of a long-chain acylsulfonate anionic surfactant represented by the belowmentioned general formula (1) such as a stearoyl methyl taurate, and (C) 0.1-5 mass% of tranexamic acid. R1CO-a-(CH2)nSO3M1 (1) (R1CO- is a saturated or unsaturated fatty acid residue having an avera...

Disclosed is a hair-dressing cosmetic which exerts good hair-dressing effect and good hair-redressing effect, although being water-based and having a low viscosity, shows no stickiness and high smoothness, and gives the sense of a light finish. Specifically disclosed is a hair-dressing cosmetic, comprising: (a) a polyalkylene glycol polymer (a1) or a sugar alcohol (a2), both being in a solid state...

Disclosed is a hair-dressing cosmetic which exerts good hair-dressing effect and hair-redressing effect, although being water-based and having a low viscosity, shows no stickiness and high smoothness and gives the sense of a favorable light finish. Specifically disclosed is a hair-dressing cosmetic containing (a) 0.1-10 mass% of a pressure-sensitive adhesive resin, and (b) 3-30 mass% of one or mor...

Disclosed are: an oral composition for alleviating ultraviolet radiation-induced damage, which can be used on a daily basis and is stable and safe; and a medicinal agent, an anti-wrinkle agent and a food composition, each of which comprises the oral composition. Specifically disclosed is an oral composition for alleviating ultraviolet radiation-induced damage, which comprises at least one compound...

A stabilized oral care composition comprising a borinic acid derivative, e.g., a borinic ester.

Disclosed is a novel composition which has a function of accelerating production of laminin-332. The composition is stable and safe, and can be used routinely. Specifically disclosed is a laminin-332 production accelerating composition which contains one or more compounds selected from the group consisting of D-alanine, D-hydroxyproline, derivatives of D-alanine or D-hydroxyproline and/or salts of...

Disclosed is a hair-dressing cosmetic which exerts good hair-dressing effect and hair-redressing effect, although having a low viscosity, shows no stickiness and high smoothness and gives the sense of a favorable light finish. Specifically disclosed is a hair-dressing cosmetic containing (a) 0.1-10 mass% of a pressure-sensitive adhesive resin, and (b) 0.01-20 mass% of an oily component, characteri...