A supporting device including a first member which supports a springy means for resiliently supporting a second member. The supporting device includes a detection for detecting displacements of the springy with respect to the first member in accordance with the movement of the second member and a biasing which applies a force to the springy from the same direction as or from a direction opposite t...

There is provided new antitumor antibiotic substances designated herein as BBM-1675C and BBM-1675D, said substances being produced by selective chemical hydrolysis of the bioactive components BBM-1675A1 (esperamicin A1) or BBM-1675A2 (esperamicin A2). The new antitumor antibiotics exhibit both antimicrobial activity and antitumor activity.

Antibacterially active 11,12-carbonate derivatives of erythromycin 9-(optionally substituted)oxime and 9-imino compounds and their pharmaceutically acceptable ester or acid addition salt thereof: wherein R<1> denotes an oxime group, a substituted oxime group, or an imino group, R<3> denotes a hydrogen atom or an unsubstituted or substituted alkyl group; R<7> denotes hydrogen or methyl; on...

This invention provides an improvement in the process for preparing C-20-amino-substituted derivatives of the macrolide antibiotics of the tylosin type by reductively aminating the C-20 aldehyde group in the parent antibiotic. The improvement comprises using formic acid as the reducing agent. The new process is less expensive and more amenable to scale-up than previously used processes, but is sti...

This invention relates to a new synthetic process for the manufacture of zidovudine from the starting material D-xylose involving: (i) Conversion of D-xylose to a 1-( beta -D-xylofuranosyl)thymine derivative: (ii) 2'-Deoxygenation of the thymaine derivative; and (iii) 3'-Azidation of the 2'-deoxy compound.

A process for preparing the compound of formula (I) which comprises treating the corresponding 23 alpha - compound sequentially with (i) oxalyl chloride and (ii) 2-mercaptopyridine-N-oxide, a catalytic amount of an organic base, and a thiol.

PCT No. PCT/FR88/00282 Sec. 371 Date Feb. 2, 1989 Sec. 102(e) Date Feb. 2, 1989 PCT Filed Jun. 3, 1988 PCT Pub. No. WO88/09978 PCT Pub. Date Dec. 15, 1988.The invention relates to a method and to a device for determining the number of people to be found in a determined space, by means of a strip (14) of photodetectors (16) on which an objective lens (10) forms a linear image of a space including o...

A circuit for the detection of address transistions in an integrated circuit comprises a logic signal input terminal, a D flip-flop for memorizing the state of the input signal, and a comparator having a first input terminal connected to the logic signal input terminal and a second input terminal connected to the output terminal of the memorizing means. The comparator gives a first logic level whe...

A boost clock signal generator which provides a boost clock signal from a pair of phase clocks. A pair of differentially-connected FET transistors (46) which generate a boost clock signal. The transistors have drain connections connected to each of two clock signals, and commonly connected sources which form an output terminal for the boost clock signal. A series pass FET transistor (58, 59) is co...

A redundancy decoder of an integrated semiconductor memory having a plurality of decoder stages containing a switching transistor and a separable connection having respective conditions in which the separable connection is severed and intact, as well as at least one charging transistor, comprising, in each of the decoder stages, an addressing circuit connected to and between the switching transist...

A microcomputer system has a first, low order address, memory soldered to the planar printed circuit board and can accept further memory pluggable into a socket on the board. At power on self test, the memories are tested, and, if an error is detected in the first memory, this memory is disabled by directing the lowest order memory addresses to the second memory and reducing the highest order addr...

In a method of forming an assembly in which a semiconductor element (1, 2) is secured on an insulating plate (3) which is surrounded by an insulating frame (5), the plate and the frame bear on a metal support (4) and a cover (9) is fixed over the frame. An initial step involves the formation of a subassembly (60) comprising the element (1, 2), the plate (3) and the frame (5), the element (1, 2) be...

Compounds are described of formula (II) (II) and salts thereof, wherein R1 reprsents a methyl, ethyl or isopropyl group; R2 represents a hydrogen atom or a group OR5 (where OR5 is a hydroxy group or a substituted hydroxyl group having up to 25 carbon atoms) and R3 represents a hydrogen atom, or R2 and R3 together with the carbon atom to which they are attached represent a >C=0 group; an...

PROCEDIMIENTO DE OBTENCION DE NUEVOS COMPUESTOS INTERMEDIOS DE UTILIDAD PARA LA PREPARACION DE SACARIDOS ADECUADOS COMO MEDICAMENTOS, DE FORMULA (III) EN DONDE LOS RADICALES TIENEN LOS SIGNIFICADOS INDICADOS EN LA DESCRIPCION. COMPRENDE CONVERTIR EL GRUPO HIDROXI SIN PROTEGER, QUE ESTA PRESENTE EN UN COMPUESTO DE FORMULA (IV), EN UN GRUPO ESTER FOSFATO PROTEGIDO; O BIEN ACILAR UN COMPUESTO DE FORM...

UN METODO MEJORADO PARA PRODUCIR UNA PROTEINA HETEROLOGA. COMPRENDE CULTIVAR UNA CELULA HUESPED, O SU PROGENIE, TRANSFORMADA CON UN VECTOR CAPAZ DE DIRIGIR LA EXPRESION DE LA PROTEINA HETEROLOGA, CUYA CELULA HUESPED ESTA ADICIONALMENTE TRANSFORMADA CON UN VECTOR SELECCIONADO DEL GRUPO FORMADO POR: A) UN VECTOR DE EXPRESION ANTISENTIDO GRP78/BIP, B) UN VECTOR QUE CONTIENE UNA SECUENCIA DE DNA DETER...

PROCEDIMIENTO PARA PREPARAR 6-SULFENAMIDO-, 6-SULFINAMIDO- Y 6-SULFONAMIDO-PURINAS, NUCLEOSIDOS DE PURINAS Y NUCLEOTIDOS DE PURINAS ANTITUMORALES DE ESTRUCTURA DONDE Z ES H O -NH2; X ES -S-NH2, -SO-NH2 O -SO2-NH2; G, T Y Q SON C-H O N; Y ES H O UNA *FORMULA* PENTOFURANOSA O *FORMULA* -PENTOFURANOSA DE FORMULA:DONDE R1 Y R2 SON H, OH, -O-ACILO O O=P-OH-OH-O-, O REPRESENTAN CONJUNTAMENTE O=P-O-OH-O-...

The present invention relates to antitumor 4 min -demethylepipodophyllotoxin glucosides having phosphate or sulfonate substituents on the sugar portion of the molecule.

The invention provides novel orally active ion multiplets of the formula (I) in which is the skeleton of a polyol, n is the number of OH's in the polyol (3 to 24); p is > 3 and < n; r is the available valence of the heparin unit and > 3 and < 7; sr is equal to pv; and R+ is (a) (b) (c) or (d) (e) in which RiV is C1-C3 alkyl; R' and R" are C1-C7 alkyl, the same of diff...

Amino sugar carbonating agents and their preparation Carbonating agents are prepared by reacting bicarbonate ions with the amino moiety of glucosamine or galactosamine in aqueous solution to form glucosamine bicarbonate or galactosamine bicarbonate. The bicarbonate is then isolated by drying. The resulting dry 2-amino sugar bicarbonate is stable at room temperature and can be used as a carbonating...

A memory system includes a data storage matrix having columns and rows and a redundant storage matrix having at least one column. The columns of the storage matrix are addressed by column addresses each defining a logical column address for a data bit of a row and corresponding to a predetermined physical column of the storage matrix. The storage matrix is readable in parallel, the parallel read d...