The present invention relates to substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, and the use of such compounds for the preparation of a medicament for the treatment of cancer in a mammal. It is postulated that treatment of cancers is achieved in which inhibition of protein synthesis and/or inhibition of activation of the mTOR pathway is an effective method for reducing cell growth. Exa...

PROBLEM TO BE SOLVED: To provide an insect-proof agent exhibiting high insect-proof efficacy, clearly indicating the end poind of use because the evaporation of a room temperature-evaporating chemical and sublimation of a sublimable substance are completed in nearly the same period and having excellent productivity.

SOLUTION: The insect-proof agent is obtained as follows. A chemical carrier...

PROBLEM TO BE SOLVED: To enhance the durability of a cover material made of a real leather skin.

SOLUTION: The automotive real leather composite is composed of a real leather skin 10 and a film 20, which is disposed on the rear surface of the real leather skin 10, and has a moisture permeability at 80°C of not higher than 500 g mm/m2/day and a modulus of elasticity in tension at 25...

PROBLEM TO BE SOLVED: To enable a user to freely select and use an optional coil element.

SOLUTION: A local signal controller 89 controls PLL 80-1 to 80-m and mixers 81-1 to 81-m to convert magnetic resonance signals to be processed in magnetic resonance signals of plural receiving channels to signals of plural effective channels determined within a first frequency band, and to convert magn...

PROBLEM TO BE SOLVED: To drastically reduce the necessary quantity of the contrast medium injection with the necessarily involved minimum X-ray exposure.

SOLUTION: In a computed tomography display method of a heart motion in a cardiac cycle by a spiral computed tomography system (1), the contrast medium is applied to a patient (7) by a contrast medium application device (11) which can be el...

PROBLEM TO BE SOLVED: To provide an optical system such as a surgical microscope which can show data to a doctor or others without using a costly and large-scale optical module, and makes operation procedures interrupted or hindered as far as possible.

SOLUTION: An optical system, such as a surgical microscope, has a stand having support arms, a microscope body, and displays. The displays 7...

PROBLEM TO BE SOLVED: To provide a pressure welding method and equipment that has high welding accuracy as well as excellent reliability and that realizes easy manufacturing, outstanding cost effectiveness and superior strength as well, in welding members together comprising a metallic element component.

SOLUTION: In welding a first member 2 having a hole 3 to a second member 4 having a sha...

PROBLEM TO BE SOLVED: To provide a driving force controller, capable of appropriate arbitration that matches a driver's will to accelerate or decelerate, while employing a configuration that provides arbitration, based on a driving force.

SOLUTION: The driving force controller includes a first target driving force calculating means for calculating a first target driving force F0, based on t...

PROBLEM TO BE SOLVED: To provide an integrated vehicle control apparatus that is less likely to be influenced by communication delays or the like between systems, while maintaining superior fail-safe properties.

SOLUTION: The integrated vehicle control apparatus includes a drive system that controls a driving force generator, a braking system that controls a braking force generator, and a d...

PROBLEM TO BE SOLVED: To provide an integrated vehicle control apparatus capable of appropriately arbitrating the requests of control units.

SOLUTION: In the integrated vehicle control apparatus, a particular manager control unit among a plurality of control units includes a first arbitrating part for arbitrating a first physical quantity dimension control target value, based on occupants' ...

PROBLEM TO BE SOLVED: To surely prevent the deformation of a lock male and the damage of a lock female.

SOLUTION: A lock device 10, which locks an upper lever 22 to a base member 1 when the upper lever 22 falls down under the condition that an operation lever 2 is at the neutral position, is provided with a lock male 8, which is provided in the upper lever 22, and a lock female 9 which is p...

PROBLEM TO BE SOLVED: To relieve the burden on a driver during driving in a congested state or the like by causing a vehicle having a manual transmission 4 to generate creep torque under suitable conditions.

SOLUTION: When the manual transmission 4 is in its neutral position and a clutch 3 is engaged, a motor 10 for driving the rear wheels of a 4WD system, for example, is used to generate c...

PROBLEM TO BE SOLVED: To reduce creep torque as intended by a driver when creep torque is generated under predetermined driving conditions.

SOLUTION: When a manual transmission 4 is in its neutral position and a clutch 3 is engaged, a motor 10 for driving the rear wheels of a 4WD system, for example, is used to generate creep torque. The amount of operation of a brake pedal is detected usin...

PROBLEM TO BE SOLVED: To provide a driving device that can miniaturize the device or improve fuel efficiency, in a device for driving a vehicle provided with a differential mechanism which distributes the output of an engine to a motor and an output shaft.

SOLUTION: The driving device for a vehicle is provided with a switching clutch C0 or a switching brake B0. By this, a gear shift mechani...

PROBLEM TO BE SOLVED: To provide a drive device for a vehicle capable of miniaturizing the drive device or improving fuel consumption.

SOLUTION: A switch clutch C0 and a switch brake B0 as a differential state switching device for selectively switching a power distribution mechanism 16 to the differential state (continuously variable shift state) operable as an electric continuously variabl...

PROBLEM TO BE SOLVED: To provide a hybrid vehicle engine start control apparatus and method capable of reducing changes in driving force, due to the transmission of torque at the first explosion of an engine.

SOLUTION: A target engine speed setting means is provided for setting a target engine speed that is not greater than the clutch input number of revolutions, i.e., the motor side number...

PROBLEM TO BE SOLVED: To simplify a structure of an axle unit which includes wet-type multiple disc brakes incorporated at both end portions of an axle housing for housing a differential, and to efficiently cool a lubricating oil around the wet-type multiple disc brakes.

SOLUTION: The axle unit A includes the axle housing 5 which houses the differential 1 and an axle shaft 2, with both wet-...

PROBLEM TO BE SOLVED: To provide a vehicular behavior state estimation device capable of estimating the detailed vehicular behavior state with an inexpensive configuration by using a phase difference, the deviation and the deviation time change rate between actual road surface reaction torque and standard road surface reaction torque.

SOLUTION: The vehicular behavior state estimation device...

PROBLEM TO BE SOLVED: To provide an automatic speed controller for reducing the mental and economical burden of a user by executing speed control corresponding to traffic circumstances.

SOLUTION: This automatic speed controller is provided with a speed detecting part 2 for detecting vehicle speed, a speed recording part 4 for preliminarily recording the maximum set speed and the minimum set...

PROBLEM TO BE SOLVED: To provide a drive unit for a hybrid vehicle with reduced power loss, and with reduced size for improving a mounting property.

SOLUTION: The drive unit is constituted of a composite planetary gear mechanism, in which two sets of planetary gear mechanisms are composed so that a differential mechanism 4 for composing/distributing and outputting power of an engine and an ...