Solvents for salt-gradient anion-exchange separation of nucleic acids, especially double-stranded DNA and especially by liguid chromatography, are improved by replacing NaCl as the eluting salt with any of a wide range of alkyl ammonium salts and can be used to elute nucleic acids in strict order of increasing length, with reduced sensitivity to elution temperature and salt concentration. Anion-ex...

Retinoids of the formula R1-OCH(R2)OC(O)R3 wherein R1 signifies 13-cis-retinoyl, R2 signifies hydrogen or lower-alkyl and R3 signifies straight-chain lower-alkyl can be used as medicaments in the case of dermatological disorders.

A Stirling engine in which a displacer plate 5 can be moved backwards and forwards between two housing plates 1, 2, the said displacer plate being without sliding friction relative to the ends 10 of the housing along the circumference, is known. It is desirable here for the Stirling engine to be designed for larger output ranges with a reduced outlay on construction by making the housing plates an...

A dragline comprising a main housing, a bucket hoist mechanism mounted on the housing, a bucket drag mechanism mounted on the main housing, a moving mechanism for moving the main housing over the ground, a boom having upper and lower ends and a rectangular cross-section, the lower end being connected to the main housing, the upper end having thereon a sheave, the boom having a longitudinal axis an...

A system interface fault isolator uses time domain reflectometry test techniques to isolate faults from only one end of a cable, a cable string or component without requiring removal of the cable or component from the system interface. A separate maintenance control unit includes a mass storage means for storing TDR or VSWR signatures of a variety of systems and comparing the signatures with data ...

Apparatus for tuning a system for detecting a target substance through the use of nuclear quadrupole resonance (NQR) or nuclear magnetic resonance (NMR). The apparatus tunes an RF coil which is employed to excite the substance under test. The tuning apparatus includes a series of fixed value capacitors switched in the tuning circuit by controllable switches. A programmable controller is employed t...

A needle shield assembly of the present invention includes a needle cannula having a proximal end, a distal end and a lumen therethrough. A hub having a proximal end for connecting to a medical instrument and a distal end connected to the proximal end of the needle cannula is provided. A base member is connected to the hub. An elongate needle shield includes a proximal end hingedly connected to th...

An improved process for the preparation of 2' and 3'-(halo-substituted)-2',3'-dideoxy nucleosides by reacting a protected anhydrothymidine compound with a halogenating composition containing a substituted organoaluminum compound which exhibits greater solubility in conventional solvents than AlF3.

A process for producing intermediate compounds 2deoxy 2,2-difluoro-.beta.-D-ribo-pentopyranose (III) from 3,3difluoro-4,5,6- trihydroxy-5,6-O-(1-ethylpropylidene)hexene (I). The process of preparing intermediate compound (I) involves reacting D-glyceraldehyde pentanide with an organometallic complex of 3-bromo-3,3-difluoropropene. The process of preparing intermediate compound (III) involves ozono...

A process for the preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine (VI) from 2-deoxy-2,2-difluoro-.beta.-D-ribo-pentopyranose (I). The process uses a tritylation reaction (Step 3) for preparing 2-deoxy-2,2-difluoro-5-O-triphenylmethyl-ribo-pentofuranose (II) as a key intermediate. The 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine (VI) is an antiviral and anti-...

Adhesive matrix layers (24) and sublayers and methods for their preparation are described. The adhesive matrix layers (24) and sublayers provide effective reservoirs for photochromic additives and can serve as an effective transition region between dissimilar materials to be used in optical articles which transmit or refract light.

PCT No. PCT/EP96/01997 Sec. 371 Date Nov. 13, 1997 Sec. 102(e) Date Nov. 13, 1997 PCT Filed May 10, 1996 PCT Pub. No. WO96/36755 PCT Pub. Date Nov. 21, 1996To avoid breakage and weak points at the points of deflection in case of a large deflection angle and deep deformations a non-woven is formed of several fiber components, which forms a flexible, dimensionally stable molded article under pressur...

A device and method for the measurement of stiffness of cartilage, specifically intended for arthroscopic use. An tissue softness probe is formed from a stiff shaft and flexible shaft, and strain gauges continuously measure the load in the stiff shaft and the deflection of the flexible shaft as they are displaced into cartilage. The stiff shaft and flexible shaft extend away from a probe body besi...

The invention is directed to a sandwich hybridization assay wherein a nucleic acid capture probe is firstly immobilized on an assay plate via masked receptors on the plate. The capture probe is immobilized by the binding of receptor ligands on the capture probe during this first step. Subsequently, target nucleic acid is hybridized to the immobilized capture probe either before or after the hybrid...

PCT No. PCT/NZ96/00028 Sec. 371 Date Feb. 2, 1998 Sec. 102(e) Date Feb. 2, 1998 PCT Filed Apr. 4, 1996 PCT Pub. No. WO96/31986 PCT Pub. Date Oct. 10, 1996The present invention relates to improvements in a three-dimensional display system. A transformation technique is described wherein deflection coordinates defining the spatial locations of the images written into the display volume are determine...

An aqueous liquid detergent composition is provided for cleaning a hard surface and for repelling insects therefrom comprising a detersive proportion of a surface active detergent compound, an effective amount of at least one of certain defined insect repellent materials which is sufficient to repel insect from the hard surface after application of the detergent composition thereto, the liquid det...

An aqueous liquid detergent composition is provided for cleaning a hard surface and for repelling insects therefrom comprising a detersive proportion of a surface active detergent compound, an effective amount of at least one of certain defined insect repellent materials which is sufficient to repel insect from the hard surface after application of the detergent composition thereto, the liquid det...

Body treatment equipment for treatment of a body part, the body treatment equipment comprising an elongated band adapted to be spirally wound around the body part so as to encase the same with successive obliquely disposed turns and encompassing along its length a series of mutually juxtaposed, longitudinally disposed band segments adapted for respectively applying a compressive load to an underly...

An acoustic ear muff includes a pad or cup (2) which is made of rigid material and incorporates an opening for receiving one ear of the wearer, and a resilient sealing annulus (10) intended for abutment with the head of the wearer, and also resilient pressure-exerting means (5) connected to the shell of a protective helmet (1), a head strap or like head gear. The ear muff provides good acoustic da...