A peptide substrate for myristoylating enzymes is disclosed having an amino acid sequence selected from the group consisting of the following sequences or a physiologically acceptable amide or salt derivative thereof: @ly-R-S-T-@, @ly-R-S-T-W- @, @ly-R-S-T-W-X- @ or @ly-R-S-T-W-X-Y- @, wherein R = Ala, Asn, Gln or Ser; S = Ala, Arg, Gln, Glu, Phe or Ser; T = Ala or Lys; W = Ala ...

A vapor-tight package has a deposit comprising nonmetallic, microwave-absorbing particles such as graphite dispersed in nonmetallic binder. When heated in a microwave oven, heat built up in the particles may soften and weaken the underlying packaging material, thus venting the package. When the deposit itself is impervious to vapors, it can be positioned over an opening in the package, and the hea...

The healing of a variety of wounds in horses is enhanced by administering to the wound a therapeutically effective amount of a composition comprising Glycyl-L-Histidyl-L-Lysine: Copper (II) or a derivative thereof in combination with a physiologically acceptable carrier or diluent. The derivatives are of the formula: [X-L-Histidyl-L-Lysine-CO-R]: Cu (II) where R is C 1-18 alkyl, C 6-12 aryl, C 1...

This invention relates to new pyranoderivatives of the formula: wherein X1 is H, Cl or Br and Z stands for: wherein X2 is H, Cl or Br, T is O or S and Y stands for an arabinose, xylose or ribose moiety, the acetylated form of the same, with either a pyranose or furanose configuration and bound to the R moiety of either the alpha or the beta anomer, to a preparation process ...

This invention relates to new pyranoderivatives of the formula: wherein X1 is H, Cl or Br and Z stands for: wherein X2 is H, Cl or Br, T is O or S and Y stands for an arabinose, xylose or ribose moiety, the acetylated form of the same, with either a pyranose or furanose configuration and bound to the R moiety of either the alpha or the beta anomer, to a preparation process ...

DERIVATIVES OF MONOPHOSPHORYL LIPID A AND PROCESS FOR PREPARATION Novel derivatives of monophosphoryl lipid A and a process for their preparation are provided. The derivatives contain one or more free groups, such as an amine, on a side chain attached to the primary hydroxyl groups of the monophosphoryl lipid A nucleus through an ester group. The derivatives provide a convenient method for couplin...

A method and pharmaceutical composition are provided for the treatment of autonomic nervous system abnormalities caused by Chagas' diseases by the administration of gangliosides, particularly a mixture of gangliosides GM1, GD1a, GD1b, and GT1b.

The present invention relates to mono-, di- and tri- esters and ethers of 5-alkynyl-substituted pyrimidine nucleosides and their use in medical therapy particularly in the treatment and prophylaxis of herpes viral infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.

The present invention relates to mono-, di- and tri- esters and ethers of 5-alkynyl-substituted pyrimidine nucleosides and their use in medical therapy particularly in the treatment and prophylaxis of herpes viral infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.

Unsaturated gasolines of both high mercaptan or hydrogen sulfide content and high gum-generator content are hydrogenated first over a palladium catalyst and then over a nickel catalyst. Resultant unsaturated gasolines are sweet and have low gum-generator content.

For preparing very finely divided emulsions (particle size

Disclosed herein is an electrode for a living body, which is used in a defibrillator and the like without hindering X-ray inspection, the main part of the electrode (hereinafter referred to as "the electrode substrate") comprising a porous material composed of granular or fibrous carbon, or a flexible and porous material composed of fibrous carbon, the electrode being made to be transparent to X-r...

The object of the invention is to improve the economics of processes for obtaining fats and oils, particularly continuous combined pressing and extraction processes, and simultaneously to ensure a high quality of the end product for different types of natural substances. To achieve this, natural substances, which may be pre-comminuted and conditioned, after pre-mixing with partially charged solven...

1. Method of producing crystalline maltitol characterized by the fact - that a mass formed from syrup and from crystals of maltitol is made to traverse, from top to bottom, continuously and with malaxation, a crystallization zone of vertical or inclined direction, in which there is established a possibly modulated temperature gradient decreasing overall downwards by 0.2 to 2 degrees C/hour, prefer...

The invention relates to parasiticidally and insecticidally highly active compounds of formula I (I) wherein R1 is hydrogen or a protecting group; R2 is methyl, ethyl, isopropyl or sec-butyl; and R is a radical R3 which is bound through oxygen or sulfur and is selected from the group consisting of C1-C10alkyl, C1-C10haloalkyl, C1-C10hydroxyalkyl, C1-C10mercaptoalkyl, C2-C10alkoxyalkyl...

A process is disclosed for producing substantially pure liquid carbon dioxide, and subsequently re-evaporating the substantially pure liquid carbon dioxide to produce substantially pure gaseous carbon dioxide from impure carbon dioxide gas which is produced during the fermentation step of a brewing process or has been used as an overgas in a brewing plant, the substantially pure gaseous carbon dio...

This invention relates to a leash which coils up automatically when the handle is released. The invention comprises a generally cylindrical center portion with handles on either side, which is manufactured in two parts and can be assembled easily. The two parts are then sonically sealed to provide a strong and secure body. A retractable spring is fixedly attached inside the body in such a manner t...

Phosphorus-contg. derivs. of 4'-demethyl epipodophyllotoxin glucosides of formula (I) and pharmaceutically acceptable salts are new, where R1 and R6 together complete a 5-6C cycloalkyl gp.; or R1, R6 = 1-8C alkyl; or R6 = H; and R1 = 1-10C alkyl, 2-10C alkenyl, 5-6C cycloalkyl, 2-furyl, 2-thienyl, 6-10C aryl, 7-14C aralkyl or 8-14C aralkanyl, where the aromatic rings are opt. substd. by halogen, 1...

The compound 4 sec -deoxy-4 sec -N-methylamino avermectin Bla/Blb has been discovered to have unexpected properties when used as an agricultural insecticide. Specifically, the compound is considerably more active against insects, particularly lepidoptera, than closely related compounds, and the compound exhibits significantly lower levels of mammalian toxicity and aquatic animal toxicity. Thus the...

The present invention pertains to a method of purifying crude polyol fatty acid polyesters, in particular sugar polyesters, comprising, preferably more than one, alkaline washing treatments at pH of at least 12.5, optionally in combination with water and/or acid washing treatments and further conventional refining steps. By this method better colour-removal and stability against high-temperature d...