PURPOSE:The titled composition for raising endermic absorption of generalized drug at low voltage and at low electric current, containing a nicotinic acid or isonicotinic acid alkyl ester as an essential component and further an organic solvent and water in a specific ratio. CONSTITUTION:A base composition for biological electrode of iontophoresis containing a compound shown by formula I (R is 6-2...

PURPOSE:A composition for exodermis administration for raising drug permeability through skin and endermic absorption, containing a specific ester as an essential component. CONSTITUTION:A composition for exodermis administration having raised endermic absorption, containing an ester shown by the formula I (ring A is 5-7- membered ring; R is 5-13C chain hydrocarbon residue; p=0 or 1; X is H, lower...

PURPOSE:To provide a composition for dermal administration, containing a nicotinic acid ester, and effective to increase the transcutaneous permeability and absorptivity of the drug component. CONSTITUTION:The objective composition for dermal administration and effective to increase the transcutaneous absorptivity of a drug component can be produced by using the nicotinic acid ester of formula I (...

A composition for percutaneous drug administration which contains a compound of the general formula (I) wherein R1 is a hydrogen atom or an alkyl group and R2 is a residue of aliphatic hydrocarbon. The composition is capable of promoting percutaneous drug absorption.

PURPOSE:A base composition for external preparation, capable of raising percutaneous absorption, containing a sesquiterpene alcohol compound and a specific polar compound. CONSTITUTION:(A) 1-80wt% based on total amounts of both compounds of one or more sesquiterpene alcohol compounds, especially bisabolol, farnesol, nerolidol, santalol or vetivenol is blended with (B) one or more polar compounds s...

Disclosed are a compound of the formula wherein R1 is lower alkyl, A is a group of the formula (in which R3 is hydrogen or lower alkyl) or methylene, and R2 is hydrogen or a group of the formula -(CH2)nCOOH (in which n is an integer of 1 to 6) or a salt of the derivative, and preparation thereof. The compounds have an excellent aldose reductase inhibitory action.

1-(4-hydroxy-3-(hydroxymethyl) phenyl)-2-amino-1-ethanol derivs. of formula (I) and their salts and solvates are new. In(I) m = 2-8 and n = 1-7, provided that m+n = 4-12; Ar = phenyl opt. substd. by 1 or 2 of halogen, 1-3C alkyl and 1-3C alkoxy or by O(CH2)pO, where p = 1 or 2; R1 and R2 = H or 1-3C alkyl, provided that the total no. of C atoms in R1 and R2 is not more than 4.

This invention relates to the use of doxazosin or a pharmaceutically acceptable acid addition salt thereof as an agent for retarding the development of atherosclerosis in a mammal, especially for reducing atherosclerotic plaque involvement and for retarding and reducing both the fibrosis and lipid deposition of developing atherosclerotic plaques associated with atherosclerosis.

PURPOSE:The titled carrier, obtained by treating a structure, having a shape of beads, powder, etc., and made from cellulose as a material with a solution of an acid anhydride based high polymer, and capable of immobilizing easily a large amount of a physiologically active substance. CONSTITUTION:A carrier for immobilizing a physiologically active substance obtained by treating a structure, having...

A method and apparatus are provided for securing a plastic fastening profile, such as is used on reclosable plastic containers, to a traveling plastic film web. A freshly extruded hot fastener profile (30) is guided into convergence with a preformed traveling film web (10). The profile and web are joined together in an area (32) in which the web is insulated. Only the heat from the fastener profil...

A connector for a fiber optic member comprises a ferrule in which is positioned an insert surrounding a section of the fiber optic member adjacent an exposed end of the fiber optic member, the exposed end extending along a front bore of the ferrule. A crimping ring on the ferrule is controllably crimped thereon thereby moving arcuate sections of the insert into mechanical engagement with the fiber...

PURPOSE:To improve the insertion property of a treatment device even when the angle of inclination of a treatment device insert mouth body is increased with respect to the center axis of an operating part, by making the axial line, which connects the center of the opening part of the first passage connected to a main channel pipe and the center of the opening part of the third passage connected to...

An integrated circuit chip including a first surface (64) and a higher second surface (68), with an abrupt sidewall step transition (71) therebetween (71), and having a first layer (36) of a first conductive material disposed over the first surface and over the second surface , but terminating on the first surface level in a first end portion which extends up to but does not touch the sidewall. Th...

PURPOSE:To measure the life of operating parts by utilizing a signal generated in the light source deivce and measuring the degree of use of a lamp. CONSTITUTION:Data on the frequency of light emission of a flash discharge lamp is counted every time a synchronizing signal is sent from a camera 13 and the counted value of the frequency of synchronous light emission is stored positively in a RAM36. ...

PURPOSE:To prevent the breakage of optical fibers and to reduce the outside diameter by covering an optical fiber bundle in a curved part directly with a protective tube which is highly slippery and flexible and covering the other part with a flexible tube. CONSTITUTION:A soft endoscope 21 consists of a slender insertion part 22 covered with a flexible tube, an operation part 23 of a large diamete...

PURPOSE:To circularly take up a film by a simple structure by allowing a film take-up driving cylinder to slide on a film fitting plate body and fitting a film supporting ring made of a leaf spring which is nearly as wide as the film. CONSTITUTION:The film 4 is fitted to the film fitting plate body 2 and the film supporting ring 3 made of the leaf spring is fitted in the film take-up driving cylin...

Cannula per fleboipodermoclisi (2) comprendente una guaina (4), una porzione di manipolazione (6) e una porzione di catetere (8) nella quale detta porzione di manipolazione include un organo di serraggio (16) nel quale è montata una cannula (14), detta porzione di catetere (8) comprende un catetere (12) collegato ad una base di catetere (10) ed è supportato da detta cannula (14) e detta guaina (4)...