In the nitride semiconductor device of the present invention, an active layer 12 is sandwiched between a p-type nitride semiconductor layer 11 and an n-type nitride semiconductor layer 13. The active layer 12 has, at least, a barrier layer 2a having an n-type impurity; a well layer 1a made of a nitride semiconductor that includes In; and a barrier layer 2c that has a p-type impurity, or that has b...

Controlled release and delayed release formulations which are adapted or intended for oral administration and which contain paroxetine hydrochloride, such as a formulation which is a system for the controlled and delayed release of paroxetine hydrochloride, having (a) a deposit-core comprising 28.61 mg paroxetine hydrochloride, 18.7 mg methocel K4M, 79.14 mg lactose monohydrate, 2.50 mg polyvinylp...

PROBLEM TO BE SOLVED: To provide a dynamic stabilization device for vertebrae or bones to be connected with one another which is compactly designed using a rod-shaped element for the stabilization and restricted mobility. Ž

SOLUTION: The stabilization device for bone has two bone anchoring elements 2, 3 each including an anchoring part 12 to be anchored in a bone and a receiver member 13 and ...

A method for the remyelination of neurons is disclosed wherein neural stem cells isolated from adult or fetal neural tissue are proliferated in a culture medium containing a growth factor to produce precursor cells having a nestin (+) phenotype. The precursor cells are capable of differentiation into oligodendrocytes which, when associated with a demyelinated neuron, effect remyelination.

Methods are described for increasing the number of neural stem cells that differentiate into astrocytes, oligodendrocytes, or neurons. The methods comprise proliferating isolated neural stem cells in a culture medium having a first growth factor to produce precursor cells. The precursor cells are then differentiated into astrocytes, oligodendrocytes, or neurons in a second culture medium, EGF-free...

The invention relates to the induction of the neuronal fate in neural stem cells or neural progenitor cells. The inventors have found that a neuronal fate in a neural stem cell or neural progenitor cell can be induced by expressing Nurr1 above basal levels within the cell. Nurr1 is a transcription factor of the thyroid hormone/retinoic acid nuclear receptor superfamily. It is shown herein that the...

A combined degassing and flotation tank for separation of a water influent containing considerable amounts of oil and gas. A rotational flow is created in the tank which forces the lighter components such as oil and gas droplets towards a first baffle (5) from where they coalesce and rise to the surface of the liquid and are removed via the outlet (3) whereas the heavier parts are forced down wher...

3-(2-Alkylthio-5-acylphenyl)-isoxazoles (I) are prepared by a multi-stage process via 3-(2-aminophenyl)-isoxazole intermediates (VI). Also new are various oxime and isoxazole derivative intermediates, including (VI); and methods for preparing oximes (XV) and thioethers (XIX) . Preparation of 3-(2-alkylthio-5-acylphenyl)-isoxazoles of formula (I) involves preparing a 3-(2-aminophenyl)-isoxazole int...

Cosmetic composition for topical application comprises (2S,3R,4S)-4-hydroxyisoleucine. - Independent claims are also included for: - (1) use of (I) applied topically to combat natural signs of aging of the skin and scalp; - (2) cosmetic treatment of the skin and/or scalp by applying a composition as above; - (3) cosmetic treatment of the scalp by applying a composition as above at least every 72 h...

Device for the electro-deionization of an aqueous electrolyte solution comprises no adjustable pressure-maintaining valve in a connecting part (10).

An improved structure for gas diffusion electrodes and gas diffusion layers whereby fine gradients of porosity and hydrophobicity promote efficient gas transport, water removal and overall enhanced performance of Membrane Electrode Assemblies constructed with these components.

A device for inserting a cannula comprising a short tubular catheter (1) connected to a base (2) has a cage (5) with a chamber (6) for a sliding needle (3) to pass between its inlet (7) and outlet (8) and into the catheter. - A device for inserting a cannula comprising a short tubular catheter (1) connected to a base (2) has a cage (5) with a chamber (6) for a sliding needle (3) to pass between it...

Production of hot working gases comprises carrying out the combustion in a burner to produce a hot combustion waste gas; deviating a part of the combustion waste. The combustion is catalytically initiated in the burner and/or stabilized. Production of hot working gases comprises carrying out the combustion in a burner (2) to produce a hot combustion waste gas (11); deviating a part of the combusti...

The scaffolding element (16) is composed of a tubular section (14) provided with a number of radially projecting sockets (17) for coupling to the end of a horizontal scaffolding crosspiece. The manufacturing method comprises shaping a plane metal band and stamping it flat in several regularly spaced places so as to form dihedral imprints with a rounded edge. The stamped bands are then folded to ob...

A synthetic silicate pellet is provided having component of calcium and magnesium, either together or in the alternative. Such pellet is further provided with either an aluminate silicate binder and/or an ion flow catalyst. The synthetic silicate pellet has use as a glass batch component.

Aplidine demonstrates considerable promise in phase (I) clinical trials for treatment of tumors, and various dosing regimes are given. Tumor reduction has been observed in several tumor types including renal carcinoma, colorectal cancer, lung carcinoid, medullary thyroid carcinomas and melanoma. It has also been found that aplidine has a role in inhibiting angiogenesis, complementing the anti-tumo...

The invention concern the use of a virus for the preparation of a medicament for the vaccination or treatment of a neonatal or prenatal animal, including a human, wherein the virus is capable of infecting the cells of the neonatal or prenatal animal, including a human, but not capable of being replicated to infectious progeny virus in the neonatal or prenatal animal, including a human. The virus i...

A system and method for verifying that a medication delivery device is properly programmed to deliver a medication from a medication source. The system and method insure that the right medication is delivered in the right manner to a patient, and is particularly advantageous where multiple medications are being delivered simultaneously to a patient. The system and method also provides for ensuring...

The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in. one aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods_ for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present...