Novel antineoplastic amine-containing derivatives and methods for synthesizing such derivatives of anthracycline antibiotics are disclosed. The derivatives are useful to anthracycline antibiotic conjugates which retain substantial immunospecificity of the unconjugated antibody molecule. Using the conjugates, targeted delivery of the attached antibiotics is achieved in vivo. Such conjugates are thu...

Chemically defined conjugates of biologically stable polymers, such as copolymers of D-glutamic acid and D-lysine, and polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies. The duplexes are preferably homogeneous in length and structure and are bound to the polymer via reaction between an amino-reactive functional group ...

An image forming apparatus wherein a developing device for developing a latent image is exchangeable includes an opening for permitting mounting and dismounting of the developing device relative to a main assembly of the image forming apparatus, a path along which the developing device is movable between the opening and a predetermined position in the main assembly, a movable door for opening and ...

A memory circuit comprises a memory array (1) having a plurality of memory cells arranged in rows and columns; a plurality of column select circuits (CS0-CS7) for enabling access to columns in said array, each column select circuit being associated with a respective group of said columns and being arranged to access a selected one of the columns in the respective group; at least one spare memory ...

A pulse signal generator includes a first delay device for delaying an input pulse signal and converting the input signal into a first intermediate signal. A power supply voltage detector detects a power supply voltage and outputs a signal representative thereof. A second delay device serves to delay the first intermediate signal and to convert the first intermediate signal into a second intermedi...

2102701 9220005 PCTABS00017 A transfer-pad printing composition comprising either a latex or solution coating composition comprising a coating vehicle and a monomeric or polymeric hydroxylated and/or carboxylated surface active wetting agent that is coating compatible with the pad surface (22) such that the coating composition, provided in the shape of a pattern (20), is precisely imprinted on its...

A structure for limiting access, such as a storm door, having first and second polymer shells with at least one them having side shell portions extending at an angle from a major shell portion with these side shell portions adjoining the other shell, there being a first distribution of magnetic particles positioned between a polymer backing and both the first and second shells. The backing can be ...

The invention provides an intermediate screen for a signal light, the screen being of the type constituted by a plate for passing a flux of light, and including a set of light-deflecting grooves on at least one of its faces, the grooves being essentially concentric and each being defined by two faces of essentially rectilinear profile and of given angles of inclination relative to the normal to th...

A method for extruding a wide variety of plural-component fiber configurations in a spin pack utilizes one or more disposable distributor plates in which distributor flow paths are etched on one or both sides to distribute the polymer components to appropriate spinneret inlet hole locations. The etching process permits the distribution paths to be sufficiently small to facilitate issuing multiple ...

Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.

An improved branch prediction cache (BPC) scheme that utilizes a hybrid cache structure. The BPC provides two levels of branch information caching. The fully associative first level BPC is a shallow but wide structure (36 32-byte entries), which caches full prediction information for a limited number of branch instructions. The second direct mapped level BPC is a deep but narrow structure (256 2-b...

PURPOSE:To detect abnormality in deposition regardless of disturbance of output electric current due to variation of voltage at an electric source. CONSTITUTION:This method for detecting the abnormality in the deposition is the one, by which in the electric fusion welding, variation with the lapse of time in the current value I in the fusion welding work is continuously differentiated and when thi...

PURPOSE: To manufacture suture needle/suture assemblies in a large quantity in high quality control by integrally providing a device to fix a short-sized heat-shrinkable tube to the shank of a suture needle, and a device to fix a suture to the shank of the suture needle to which a tube is already attached. CONSTITUTION: On a fixing device 14 provided on a bench 12, a control connector 16 to be con...

PURPOSE:To provide an ultrasonic wave applicator for medical treatment, which is small and can generate sufficient sonic pressure to perform an ultrasonic wave cure by focusing ultrasonic waves on a living body deep part without affecting on internal organs or the like other than a place to be cured and ultra without distorbing ultrasonic wave transmission. CONSTITUTION:Ultrasonic waves of dozens ...

PURPOSE: To provide a surgical wrench having a contour which can approach a limited space or gap being effective for the installation of an implant for backbone fixation. CONSTITUTION: This high speed wrench 100 for surgical use has a thin contour, and is equipped with a holding means which holds a part to be installed by a fitting having a screw. This thin contour is achieved by a socket 40 which...

To monitor a patient for rejection reactions of an implanted heart, a permanent magnet is implanted epicardially in the heart wall and a magnetically active semiconductor element, preferably a Hall generator, is implanted endocardially. Movement of the heart wall results in changes in the distance between the permanent magnet and the semiconductor element. An implantable component supplies the sem...

A thermal head for use in a printer or a facsimile machine and a method for manufacturing the same are disclosed. The thermal head having a heat regenerative layer, heating elements and electrodes respectively formed on the substrate thereof and in which they are covered with a protection layer is manufactured by forming a coating made of a thermosetting resin on the protection layer. Thus, pin ho...

Bither, Ellers and Engle Case 1 ABSORBENT PRODUCT WITH HYDROPHOBIC ACQUISITION LAYER Disclosed is a laminated structure for use in an absorbent product comprising a hydrophobic liquid-transfer layer adjacent to a fluid permeable top sheet, and an absorbent layer. The hydrophobic layer comprises a thermally consolidated blend of 5% to 50% of thermally bondable hydrophobic fibers and 50% to 95% wood...

Pour exploiter les mesures de pression et de températures délivrées par un dispositif de surveillance des pneumatiques, on calcule pour chaque pneumatique l'estimateur du nombre de môles P/T, puis on construit un indicateur d'état anormal en combinant par des opérations algébriques les valeurs dudit estimateur pour plusieurs pneumatiques.; In order to monitor gas leakage in the tires of a vehicle,...

A portable display structure (10) comprising a number of upright columns (12) joined by a number of horizontally extending beams (16,18), the columns (12) and/or beams (16,18) being formed in a similar manner of a central structural member made of a number of units (20,22) and each unit (20,22) comprising a plurality of rod elements connected at their ends to associated hubs.