The present invention provides an asymmetric hydrogenation process for the preparation of chiral cycloalkanoindole DP receptor antagonists in high enantiomeric excess.

A compound represented by the following general formula (I), its salt, solvates thereof or prodrugs thereof: (wherein each symbol is as defined in the description.) The compounds represented by the general formula (I) are useful in preventing and/or treating various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcer...

The present invention provides a compound of formula I: wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein. The present invention also provides pharmaceutical compositions and methods using such compositions for treating a caspase-mediated diseases and processes for preparing the compounds of the invention.

A process for the manufacture of the calcium salt of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3 R ,5 S )-3,5-dihydroxyhept-6-enoic acid, useful as an HMGCoA reductase inhibitor, from a compound of the formula (7) wherein A is an acetal or ketal protecting group and R is alkyl, via isolated crystalline compounds of the formula (8) or of formula (10) ...

A process for preparing a thiazole compound of formula (3): wherein X¹ represents a hydrogen atom or a halogen atom comprising reacting a compound of formula (1): wherein X¹ is as defined above, and X² represents a halogen atom, with ammonia and formaldehyde to obtain a hexahydrotriazine compound of formula (2): wherein X¹ is as defined above, and hydrol...

This invention relates to a method for treating HCV infection. The method includes administering to a subject in need thereof an effective amount of one or more of sesquiterpene lactones having a gamma-lactone fused with a 10-membered ring, an 8-membered ring that is further fused with a 4-membered ring, a 7-membered ring that is further fused with a 5-membered ring, or a 6-membered ring that is f...

A series of brairane-related junceol compounds, including junceol A, junceol B and junceol C, are isolated from the sea whip gorgonian coral Junceella juncea. An isolating method for brairane-related junceol compound includes the steps of: extracting a preliminary material from Junceella juncea; partitioning the extracted material so as to provide a partitioned material; separating the partitioned...

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R 1 and R 2 are H or alkyl; R 3 and R 4 are halogen, H,...

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising Formula I: wherein M is N or CR4; Q<1> and Q<2> are each independently selected from the group consisting of CO, SO, SO2, and C=NR9; and each R1, R2, R3, R4 and R9 are as defined herein.

The present invention relates to a clottable concentrate of platelet growth factors for therapeutic and/or cosmetic use, preferably comprising the growth factors PDGF, TGF-β , IGF, EGF, CTGF, bFGF and VEGF. In preferred embodiment said clottable concentrate of platelet growth factors does not induce blood cell-related transfusion reactions. The present invention also relates to a method for prepar...

The present invention provides a perfluoroelastomer seal material in which adhesive strength, contamination, corrosion and color change of a contacted surface with a seal material are improved, and an amount of an uncrosslinked polymer component is at most 1 % by weight, measured under specific conditions, and a process for preparing the same. The present invention relates to a perfluoroelastomer ...

By resolving objections in the prior art, provided are a novel copolymer suitable as a coating polymers which is excellent in adhesion to a substrate and can be used suitably as the polymer for the coating film having durability against pattern collapse in the finer pattern formation for progressed lithography technology and a method for producing the copolymer, as well as a novel thiol compound u...

A practically useful polyesterimide which has a low permittivity, low coefficient of linear thermal expansion, and high glass transition temperature and has film toughness sufficient in flexible printed wiring boards; a precursor for the polyesterimide; and a process for producing these. The polyesterimide is characterized by containing repeating units represented by the formula (2): wherein A and...

The invention provides branched copolymers as precursors for preparing silicon carbide (SiC) ceramics represented by the general formulae: [Si(˜)RC(˜)H]xn[SiR1R2CH2]yn,  Formula Type-I wherein n is the degree of polymerization, 0.1≰x<0.8, 0.2≰y<0.9 and x+y=1; and R=methyl or H, R1 and R2 are randomly composed of hydrogen (H), allyl, methyl (Me), phenyl (Ph), propargyl or vinyl. Another branched co...

A method for synthesizing monodipersive polymeric microspheres is disclosed. The method can control the diameter distribution of the microspheres and make it homogeneous. The manufactured polymeric microspheres also have plural functional groups on the surface for depositing metal particles thereon through redox. Moreover, the metal particles can be distributed on the surface of the polymeric micr...

Flexible foamed polyurethane moldings of density below 500 kg/m3 and DIN ISO 02769 maximum shrinkage 1.5% are obtained from mixtures of (a) organic isocyanates; (b) specified polyols; (c) crosslinkers/chain extenders; (d) blowing gents comprising nitrogen, air and/or carbon dioxide together with a chemical and/or physical blowing agent of boiling point -30 to +75degreesC; and optionally also ...

PROBLEM TO BE SOLVED: To provide a foamed molded article capable of preventing oozing of oil and coloring matter, a method for producing the same, and a food package obtained by containing and packaging food or the like in the foamed molded article. Ž

SOLUTION: The foamed molded article is obtained by foaming expandable polystyrene-based resin particles for foaming, wherein the expandable pol...

Disclosed is an electrically conductive thermoplastic polymer composition comprising a thermoplastic polymer, an impact modifier and a combination of metal fibers and metal-coated fibers, structures made therefrom, and a process to make said compositions and structures.

The present invention presents a light diffusing polycarbonate resin sheet obtained by coextruding a polycarbonate resin composition containing an antistatic agent as an essential component as a surface layer on at least one side of a base material comprising a polycarbonate resin composition containing a light diffusing agent as an essential component, wherein the antistatic agent of said surface...