Therapeutically useful N-(1-benzylpiperid-4-yl)-benzamides of the formula: (wherein X represents a chlorine or bromine atom, R1 represents an alkyl group containing up to 6 carbon atoms, R2 and R3 represent hydrogen atoms or one of those symbols represents a chlorine atom in the 3- or 4-position or a methyl or methoxy group in the 4-position and the other symbol represents a hydrogen atom, or R2 a...

PURPOSE:A solution of 1-(2'-tetrahydrofuryl)-5-fluorouracil in an aq. solution of a basic substance of freeze-dride to make powder suitable for injection use.

A process for the preparation of a compound of the formula:; or a pharmaceutically acceptable acid addition salt thereof, wherein R is hydrogen, methyl or hydroxymethyl which comprises treating a compound of the formula:- wherein R<1> is benzyl and R<2> is hydrogen or methyl, or R<1> and R<2> are taken together and are with hydrogen; or, alternatively, to produce a compound i...

PURPOSE:To obtain a microspheric prolonged release composite, by dissolving a physiologically active substance in a buffer solution, preparing a composite emulsion containing a vinyl polymerizable monomer, and polymerizing the monomer by the irradiation with ionizing radiation, etc. CONSTITUTION:A physiologically active substance is dissolved in a buffer solution of an adjusted pH, and a polymeriz...

Novel N-(1-substituted-3-pyrrolidinyl)-1-naphthalene and 4-quinolinecarboxamides of the formula: wherein R is lower cycloalkyl, R1 is hydrogen, lower alkyl or aryl, R2 is hydrogen, lower-alkyl, halogen, lower-alkoxy, amino or nitro, R3 is hydrogen, lower-alkyl, halogen, lower-alkoxy, amino or nitro, Y is carbon or nitrogen and pharmaceutically acceptable acid addition salts thereof hav...

Compounds of the formula wherein A is where R1 is hydrogen or alkyl of 1 to 3 carbon atoms; R2 is alkoxy of 1 to 3 carbon atoms; R3 is alkoxy of 1 to 3 carbon atoms or, together with R2, methylenedioxy or ethylenedioxy; R4 is hydrogen, alkyl of 1 to 3 carbon atoms or benzyl; R5 is hydrogen or alkyl of 1 to 3 carbon atoms; R6 is hydrogen or alkoxy of 1 to 3 carbon atoms; R7 i...

The invention concerns novel guanidine derivatives of the general formula (I) (I) or pharmaceutically acceptable acid addition salts thereof, where &cir& Nrepresents wherein R1 and R2 each represent hydrogen, lower alkyl, trifluoromethyl or halogen and R11 and R12 each represent hydrogen, lower alkyl, trifluoromethyl or halogen with the proviso that when one or both ...

The invention provides erythrocytes of improved O2-release properties having fused thereto small allosteric effectors, f.i. inositol hexaphosphate-containing lipid vesicles. Also included in the invention is a method for making said erythrocytes and plasma containing said erythrocytes.

Novel imidazole derivatives of the formula wherein R1 is hydrogen, nitro or amino, R2 is a phenyl, furyl or thieyl group which may be substituted by halogen, lower alkyl, lower alkoxy or di-lower-alkylamino, R3 is hydrogen or lower alkyl and X is halogen, and their physiologically acceptable salts, have excellent diuretic and hypotensive actions.

An ophthalmic composition in the form of a gel comprises an aqueous solution of a carboxyvinyl polymer, a water-soluble basic substance and an ophthalmic drug admixed therewith, the gel having a pH of 5 to 8 and a viscosity of 1,000 centipoises to 100,000 centipoises at 20 DEG C.

PURPOSE:To prevent error due to thermal expansion of a ball screw by furnishing a heat emitting member for heating of the ball screw and a temperature control device for this heat emitting member and thereby controlling the temperature of the ball screw. CONSTITUTION:A temp. sensor 5 is buried in a ball nut 3 in engagement with a hollow ball screw 2 to be driven for rotation. The oil in an oil tan...

NEW MATERIAL:The 1,4-dihydropyridine derivative of formulaI(R is lower alkyl; R1 is 2- or 3-nitrophenyl; X is ethylenedioxy or oxo; n is 1 or 2) having carbonyl or cyclic ketal group in the 5-position carboxylic acid ester residue. EXAMPLE:3-Ethyl 5-(2,2-ethylenedioxypropyl-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydrop yridine-3,5-dicarboxylate. USE:An agent for increasing blood flow in the coronary...

PURPOSE:Azetidinone compounds of formula I[R<1> is amino, substd. amino, substd. hydroxy, azide, halogen; R<2> is H, hydroxymethyl, aralkoxyiminomethyl, aryl;R<3> is a radical of formula II(R<4> is aryl;R<5> is carboxyl) or of formula III(R<6> is alkyl;R<7> is H, halogen)]; for example, D-2-(2-oxophthalimido-1-azetiainyl)-2-(2-theinyl) acetic acid methyl ester.

A method of fabricating an optical fiber connector is disclosed using a transfer molding process employing a precision die whose interior surface defines a frustum for forming the mating surface of the connector. The fiber is inserted through the mold cavity and extends through an aperture in the end surface of the frustum and through an annulus disposed outside of the mold cavity immediately adja...

1464603 Photochromic materials and uses thereof H G HELLER 2 July 1975 [31 July 1974] 33719/74 Heading C4S [Also in Division C2] The invention comprises photochromic compounds (I) and (II) in which A represents oxygen or NR4 (where R4 represents hydrogen, alkyl having 1 to 20 carbon atoms, cycloalkyl having 5 to 12 carbon atoms, aralkyl having 7 to 9 carbon atoms, aryl having 6 t...

PURPOSE:Aminoalcohol derivatives of formula I (R is amino, OH, lower alkoxy, acyloxy, aroyloxy, acylamino, aroylamino; A is lower alkyleneF R<1> is H, acyl;H, lower alkyl; ring P is radical which together with N atom forms piperidine, 4-substd. piperidine or 4-substd. piperazine) and their acid addition salts, e.g. 1-(4-(2-acetamidoethyl)phenyl)-2-(4-(o-tolyl)-1-piperazinyl)-ethanol.

PURPOSE:An agriculatural and horticultural pesticide effective to rice blast, helminthosporium leaf spot of rice plant, powdery mildew of cucumber, etc., free from phytotoxicity, and harmless to man, beast and fish, containing a specific pyrazolylpyrimidine derivative as an effective component. CONSTITUTION:A composition containing a pyrazolylpyrimidine derivative of formula [R1 is lower alkyl, ph...

NEW MATERIAL:An imidazolium halide of formulaI:[R1 is alkyl or cycloalkyl group; A is lower alkylene group; r1 is H, alkyl or amino group; r2 and r3 form a benzimidazole ring together with the inidazole ring. or H; X is halogen; R2 is formula II: (R3 is amino, lower alkylamino group, etc.), formula III: (R4 is H or halogen; R5 is H, lower alkylcarbamoyl group, etc.)]. EXAMPLE:N-Undecyl-N'-(2,4-dic...

This disclosure relates to an electrically alterable amorphous memory device which can be switched from a high resistance state to a low resistance state, which device has a stable voltage threshold that is temperature insensitive throughout the lifetime of the device. The memory device is formed of a graded structure having at least three regions or layers of amorphous material selected from the ...

NEW MATERIAL:A compound shown by the formulaI[A is group shown by the formula II-IV; R1 is halogen-substituted thienyl; R2 is thienyl; R3 is (halogen-substituted) thienyl; R3' is capable of being linked to R3'' or R3''' to form a ring; Q is H or (halogen-substituted) phenyl]. EXAMPLE:alpha-Methylene-gamma-phenyl-gamma-(2-thienyl)-gamma-butyrolac tone. USE:A herbicide and an insectide. PROCESS:A ca...