[14-14C]-daunorubicin and doxorubicin are prepared by reacting 9-desacetyl-9-formyl-N-trifluoroacetyl daunorubicin with [14C]-diazomethane to form [14-14C]-N-trifluoroacetyl daunorubicin from which the protecting group is removed by mild alkaline hydrolysis to afford [14-14C]-daunorubicin which is then, in the form of the hydrochloride, reacted with bromine to form the corresponding labelled 14-br...

A micropackage (1) for encapsulating an electronic component (5), includes a body fitted with a plurality of external connection tabs (2) which pass underneath the body (at 3) and which terminate in tips (17) located underneath the body. The body is made of a material which is not wettable by solder (e.g. plastics or ceramics). At least one groove (15) is formed in the underside of the body in the...

The invention relates to an apparatus for continuous comminution, homogenisation and dispersion of pumpable materials, such as solids/liquid mixtures having high solids concentrations. In a stator/rotor system the product is passed through a shearing field, differently shaped radially extending grooves in the rotor and stator achieving uniform mixing and thus complete homogeneity of the material t...

The present invention relates to novel nucleoside derivatives of formula (I), wherein, B is adeninyl, cytosinyl, 5-fluorouracyl, 5-azacytosinyl, 6-mercaptopuryl or 7-deazaadeninyl; A and C, which may be the same or different, are each hydrogen or a hydroxy group; W is a saturated or unsaturated C8-20 alkyl group or a 2- or 3-alkoxyalkyl group; and W' is a saturated or unsaturated C7-19...

A novel process for the preparation of a conjugate of a 21-hydroxy steroid and a nucleoside-5'-monophosphate comprises reacting the 21-hydroxy steroid with a derivative of the nucleoside-5'-monophosphate (in which hydroxy groups on the carbohydrate ring are protected) in the presence of 2,4,6-triisopropylbenzene sulphonyl chloride (TPS) as a condensing agent under anhydrous conditions and removing...

A new process for the preparation of 6-deoxyanthracyclinones of general formula I: I wherein R represents a hydrogen atom, a hydroxy group or a lower alkoxy group is described. The process provides a total synthesis of the 6-deoxyanthracyclinones of formula I using 1,2,3,6-tetrahydro-phthalate as starting material. The obtained racemic mixture of the compounds of formula I, if desired, ...

A new process for the preparation of 6-deoxyanthracyclinones of general formula I: I wherein R represents a hydrogen atom, a hydroxy group or a lower alkoxy group is described. The process provides a total synthesis of the 6-deoxyanthracyclinones of formula I using 1,2,3,6-tetrahydro-phthalate as starting material. The obtained racemic mixture of the compounds of formula I, if desired, ...

The present invention relates to milbemycin derivatives of the formula I (I) wherein X is hydrogen or beta -halogen, R is methyl, ethyl, isopropyl or sec-butyl and Az is a 5 membered heterocyclic aromatic ring which contains 2-4 nitrogen atoms and is attached in the 1-position and which is unsubstituted or substituted by one or two C1-C6alkyl groups. These compounds, and the acid add...

Difluoronucleosides are useful for treating neoplasms in mammals.

The invention relates to parasiticidally and insecticidally highly active compounds of formula I (I) wherein R1 is hydrogen or a protecting group; R2 is methyl, ethyl, isopropyl or sec-butyl; and R is a radical R3 which is bound through oxygen or sulfur and is selected from the group consisting of C1-C10alkyl, C1-C10haloalkyl, C1-C10hydroxyalkyl, C1-C10mercaptoalkyl, C2-C10alkoxyalkyl...

The invention relates to a method for preparing inner ester ganglioside derivates which comprises: (a) dissolving a ganglioside or a mixture of gangliosides obtained from a mammal in a non-aqueous organic solvent; (b) converting the carboxylate groups in the gangliosides to carboxyl groups or a salt thereof by means of ion exchange; and (c) reacting the resultant ganglioside or mixture of gangl...

A film and a laminate using the film as a substrate which both are suitable for heat sealing and a process for heat sealing the film and the laminate are disclosed. The film comprises a blend of (I) at least one member selected from the group consisting of (A) elastomeric block copolymers of vinyl-aromatic compounds with conjugated diene compounds, (B) resinous block copolymers of vinyl-aromatic c...

A lubricating arrangement for an I.C. engine in which at least one lubricating pump for engine lubrication is activated by a battery-fed electric motor, independent of the I.C. engine, which supplies a preset oil quantity which is unrelated to the rpms of the I.C. engine. As this lubricating pump is driven by a battery-fed electric motor which runs up within a fraction of a second, the I.C. engine...

Contaminating metals including nickel, vanadium, iron and copper are deposited on a fluid cracking catalyst during the processing of carbo-metallic oils such as reduced crude or topped crude. These contaminating metals lead to undesirous side reactions such as dehydrogenation, coking and methyl clipping which adversely affect conversion and gasoline selectivity. An improved method and process is d...

The local variables of procedures are automatically mapped form main memory of a computer into a circular buffer comprising machine registers. As instructions are fetched from the main memory, the instructions are partially decoded by adding the stack pointer to the offset and then stored in an instruction cache. In cases where the sum of the memory locations required by the procedures exceed avai...

A drive aggregate is operated independently from the availability of external air, by using a fuel being composed of a blend of hydrocarbons and metal, e.g. lithium hydrides in a pasty, pumpable, i.e., fluidized, condition, and a metal chlorate, e.g., lithium chlorate or metal perchlorate is used as an oxidizer, having been rendered fluid in a high concentration by the addition of water so that th...

The invention solves the problem of reducing the mass and the manufacturing price of this material whilst maintaining all other properties. The essence of the invention consists in the material comprising at least one layer of a heat-resistant fabric provided at least on one side with a protective layer of 1.0 to 5.0 % by weight of sodium fluorosilicate, 30 to 60 % by weight of water glass and, su...

This invention relates to a method for preparing a hydrodesulfurization catalyst which comprises (a) preparing a filter cake of amorphous alumina hydrate at a pH of 7.5-10.5; (b) dewatering the above prepared filter cake by a filter press to raise the Al2O3 concentration to 28-35% by weight and kneading the dewatered filter cake for at least 10 seconds by a self-cleaning type kneader; (c) kneading...

The invention provides catalysts suitable for hydrotreatment of mineral oil which contain an oxide and/or sulphide derived from a metal of Group VI (B) and one from Group VIII metal and a transition alumina and which show an oxygen chemisorption above 185 micromoles per gram, preferably between 200 and 300. Preferably tha catalysts are free from anions of strong mineral acids. These catalysts can ...

A disposable infant diaper is provided having a modified "T" configuration with a substantially rectangular absorbent core making the stem of the "T" and breathable fabric making the top of the "T". The breathable fabric is substantially non-yielding in a cross-direction. The closure means are integral inside the top of the "T" which forms the back waistband portion.