The present invention relates to novel 4 min -demethyl-4-epipodophyllotoxin derivatives of formula wherein R1 is an alkyl group; X1 and X2 are each a hydroxyl group or an amino group substituted by one or two alkyls, provided that either one of X1 and X2 is an amino group substituted by one or two alkyls, and the other is a hydroxyl group and a process for their preparation. The compound...

- 14 - 100-7409 6-Alkenyl-, alkinyl-, cycloalkyl-, aryl- or aralkyl-2'-0-alkyl-adenosin derivatives of formula I . wherein R1, R2 and R3 possess the significances given in claim 1, a process for their production and their use for coronary vascdilatation, for protecting the vascular endothelium, for lowering blood lipid level and treating raised blood pressure. 3700/ST/RT

- 14 - 100-7409 6-Alkenyl-, alkinyl-, cycloalkyl-, aryl- or aralkyl-2'-0-alkyl-adenosin derivatives of formula I . wherein R1, R2 and R3 possess the significances given in claim 1, a process for their production and their use for coronary vascdilatation, for protecting the vascular endothelium, for lowering blood lipid level and treating raised blood pressure. 3700/ST/RT

The present invention relates to new and useful nucleoside thiophosphoramidite, polynucleotide dithioate phosphoramidite and polynucleotide phosphorthioamidate phosphoramidite compounds as well as the processes whereby these compounds can be used for synthesizing new mononucleotides and polynucleotides having phosphorodithioate, phosphorothioamidate, phosphorothiotriesters, and phosphorothioate in...

A process which comprises administering an antagonist of protein kinase C and/or the insulin receptor tyrosine kinase to a mammal in an amount therapeutically effective to inhibit lipogenesis in the mammal.

An improved shoulder strength adduction device is provided for use in determining the strength of a person's shoulder musculature. The device comprises a pair of hand grips connected by pivotal scissors frames to a support bar and a load bar, with a force gauge unit being mounted between the support and load bars. Exertion of manual adduction force to move the hand grips toward each other is effec...

Plastic composite bottles fabricated of polyethylene terephthalate (PET). The bottles comprise a container portion and a base portion. The base portion is formed with an upwardly extending annular saddle to contact and support the spherical lower end of the container portion. The two portions are welded together at the saddle. This invention also relates to the method of, and apparatus for, weldin...

This invention is directed toward a rubber skim stock composition and a product containing the skim stock having improved adhesion and adhesion retention with metallic reinforcement cords such as brassed steel. The invention composition comprises a vulcanizable rubber skim stock and an organic complex of cobalt or nickel with a dicarboxylic acid and is prepared by mixing the cobalt or nickel compl...

In the mfr. of high temp. insulating material from heat resistant inorganic materials (esp. qlass and/or rock fibres) using organic material addns. for bonding, finishing or the like, the novelty is that, prior to high temp. use, the material contg. the addns. is heated to decompose the addns. at least in the regions which are exposed, during use, to a temp above the decompsn. temp. of the addns.;...

Large capacity truck tankers periodically replenish the petroleum and other products in the underground storage tanks. These underground storage tanks corrode, and develop leaks releasing their petroleum products into the ground. As a result potable water supplies are contaminated, and the petroleum products remain in the ground for long periods of time. Fiberglass plastic tanks were developed to ...

A method for controlling fuel injection rate in internal combustion engine in accordance with the intake pressure and the engine speed. The method has the steps of determining the intake pressure using, as a variable, the period of time after a change in the throttle opening, and computing a basic fuel injection period on the basis of the thus computed intake pressure and the engine speed. The fue...

An improved shot tip for a metal injecting shot sleeve wherein the rear end of the shot tip is of a reduced diameter as compared to the front end of the shot tip so as to minimize drag as the shot tip moves through the shot sleeve, and a wear resistant ring is positioned in an external groove in the enlarged diameter front end portion of the shot tip to minimize wear and preclude blowby of molten ...

A hydraulic four-wheel drive apparatus for driving by a hydraulic motor four wheels: steering wheels and driving wheels, in which the steering wheels are driven by a variable capacity motor for the steering wheels and a front differential gear unit, and the driving wheels are driven by a fixed capacity motor for the driving wheels, so that, when a vehicle turns, a swash plate of the variable capac...

PCT No. PCT/JP87/00744 Sec. 371 Date Apr. 6, 1988 Sec. 102(e) Date Apr. 6, 1988 PCT Filed Oct. 5, 1987 PCT Pub. No. WO88/02826 PCT Pub. Date Apr. 21, 1988.A cooling mechanism for a clutch cover assembly having a diaphragm spring with radially extending tongues and slits between such tongues characterized by that on spaced of the tongues and adjacent to the clutch cover body are disposed vane membe...

A turning device including a moving member movable along a linear path, and a turning member which is pivotable through an angle of 90 degrees about an axis perpendicular to the linear path during movement of the turning member along the linear path. A first and a second cam follower are provided on respective first and second surfaces of the turning member. A first cam provided on the second surf...

The strut includes a bidirectional frictional damping assembly (14) which provides frictional damping under rebound and jounce conditions. A separate rebound frictional damping assembly (16), or a separate jounce frictional damping assembly (79), or both, provide differential rebound and jounce damping, with and without bidirectional frictional damping.

A sorter-finisher system having a sorting unit comprising plural number of inclined bins arranged vertically at specified intervals and a transport unit for transporting bunches of sheets distributed among the bins to a sheet binding unit. When the sheets have been distributed among the bins, the bins move to a sheet receiving opening of the transport unit one by one. The bunches of the sheets in ...

A fail-safe system for an automotive suspension control system monitors inputs from one or more sensors monitoring vehicle driving conditions and producing sensor signals indicative of suspension control parameters, and operation of a controller. The fail-safe system performs fail-safe operation by which over-steering characteristics of the vehicle are prevented when malfunction of any of the sens...

A photographing lens device wherein the optical axes of lenses can be aligned with a high degree of accuracy with a simple structure and at least a lens made of a plastic material can be secured to a lens barrel without causing a torsion thereof. The photographing lens device comprises first, second and third lenses arranged in this order from the object side. The second and third lenses have mutu...

A press-fit structure of a shaft comprising a shaft and a member to be fitted with the shaft formed with a shaft hole for receiving the shaft therein, the shaft being formed at a predetermined position of the peripheral surface thereof with a meshing shaft portion which is formed with a plurality of meshing projections in the axial direction, the shaft hole being formed in an inner peripheral surf...