The invention relates to novel 15-membered 8a- and 9a-lactams from the class of 6-O-methyl-erythromycin A of general formula (I)their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, to intermediates for their preparation, to a process for their preparation, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to their h...

2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a rea...

A structured deformation resistant composite of use as a proppant in fracturing is formed from particles having a particle size distribution of at least two modes and a binder. The particle size distribution is preferably bi-modal or tri modal. The composite may further contain a density modifying agent. The particles are preferably substantially spherical and may be ultra lightweight material.

PCT No. PCT/GB92/00663 Sec. 371 Date Oct. 28, 1993 Sec. 102(e) Date Oct. 28, 1993 PCT Filed Apr. 13, 1992 PCT Pub. No. WO92/18053 PCT Pub. Date Oct. 29, 1992.Method and apparatus for testing an implant attached to a bone of a human or animal subject includes a member releasably attached to the implant. The member carries a transducer for exciting the member with a variable frequency AC signal, and...

A mixed metal compound for pharmaceutical use is free from aluminium and has a phosphate binding capacity of at least 30 %, by weight of the total weight of phosphate present, over a pH range of from 2-8. The compound is especially useful for treatment of hyperphosphataemia. The metals are preferably iron (III) and at least one of calcium, magnesium, lanthanum and cerium. A metal sulphate for phar...

A method for increasing electrical resistivity of at least a portion of a substrate includes providing a ceramic substrate and carrying out at least one of ion implantation and plasma immersion on the ceramic substrate with ions derived from at least one source selected from the group consisting of noble gases, nitrogen, oxygen, halogens, halogen compounds, silicon, and antimony. The method provid...

A method for optimizing a prescription for laser-ablation corneal treatment includes the steps of receiving a measured correction prescription for a current patient having a classification element associated therewith, the prescription having been measured using wavefront determination. A database of treatment outcomes on a plurality of previously treated patients is accessed, each treated patient...

The invention relates to compounds of Formula (IIf) or a salt or solvate thereof, wherein R<3>, Het, X and Z<1> are as described in the specification, pharmaceutical compositions containing them, their use in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes, and methods for their preparation.

Purified and isolated IL-1/TNF- alpha -activated kinase (ITAK), nucleic acids encoding ITAK, processes for production of recombinant forms of ITAK, pharmaceutical compositions containing ITAK, and use of ITAK in therapies and in various assays, including assays to detect antagonists and agonists of ITAK are provided.

This invention relates to an improved floor covering system comprising a locking system. The floor covering system can be used as underpad underneath many types of surface coverings, such as synthetic turf, carpet, coating, tiles, etc. or as floor covering without surface covering. The floor covering system consists of panels made of one o r a plurality of layers of material made from various comp...

There is provided a process for removing hydrocarbons from hydrophilic solutions in which the adsorbent is regenerated in situ. A solution containing at least one hydrocarbon impurity is passed through a resin bed and the hydrocarbon is retained by the resin. The solution passes from the resin bed substantially reduced of hydrocarbons. The filtration bed containing the resin is regenerated in situ...

A three-dimensional display device includes a two-dimensional display displaying a first image, and a variable focusing lens receiving light from the two-dimensional display and forming a second image. The variable focusing lens reflects light from the two-dimensional display. The first image includes a predetermined number of first depthwise images that are displayed within a unit time, and the s...

The delivery end of the channel (30, 32) is provided with a one-piece plastic valve element (46) with a valve surface (50) interacting with the sealing edge or surface (40) of the channel. It is also provided with a spring element (54) which interacts with the channel section (42) in such a way that a preload acts on the valve element (46). As a result of this preload, the valve surface (50) is pr...

A method and system are provided for integrating partitions in a virtual machine environment. Specifically, a partition bus is provided, where the partition bus operatively connects partitions in such a way that it functions as a data transport mechanism allowing for data transfer and device sharing between partitions. The partition bus relies on virtualizing software in order to establish itself ...

A cleaning device has an elongated handle attached to a housing. The housi ng includes a stationary brush extending through the housing. Also, the housing includes a rotatable brush, as well as a debris collector. In a first position the cleaning device is used as a conventional broom. The handle is pivoted to a second position whi ch enables the broom to be used as a debris collector.

A medical device is provided for use with an endoscope. The medical device c an include a tissue resection device comprising an RF cutting wire. The tissue resection device can be supported for proximal and distal movement relative to the endoscope.

A medical apparatus and method useful for positioning one or more members within the gastro-intestinal tract is disclosed. The sheath can be provided with textur e on an inside surface to facilitate installation of the endoscope in the sheath, and to permit the endoscope to be gripped through the sheath.

A medical apparatus and method useful for positioning one or more members within the gastro-intestinal tract is disclosed. The medical apparatus can include a track supported on a sheath sized to receive an endoscope, and a carrier slidable with respe ct to the track. A feeding tube accessory adapted to slidably engage the carrier is disclose d.

A medical apparatus and method useful for positioning one or more members within the gastro-intestinal tract is disclosed. The medical apparatus can include a track supported on a sheath sized to receive an endoscope, and a carrier slidable with respe ct to the track. A feeding tube accessory adapted to slidably engage the carrier is disclose d.

A medical apparatus and method useful for positioning one or more members within the gastro-intestinal tract is disclosed. The medical apparatus can include a track supported on a sheath sized to receive an endoscope, and a carrier slidable with respe ct to the track. A feeding tube accessory adapted to slidably engage the carrier is disclose d.