The present invention concerns the novel alkyl substituted heterocycles of formula I, set out below, wherein Q, Q<1>, Q<2> and R have the values defined herein, which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor making them useful whenever such antagonism is desired, such as in the treatment of asthma and related condit...

The invention relates to new compounds of formula I: (I) in which: m represents zero, 1, 2, 3 or 4, n and p represent zero, 1 or 2, W represents an oxygen atom, an -NH- radical, or a single bond, R represents a benzocyclobuten-1-yl radical, or an indanyl radical, a 2,3-dihydrobenzofuran-2-yl R1 represents a hydrogen atom, an alkyl radical having from 1 to 6 carbon atoms, or an aryl radic...

Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors are provided which have the structure wherein n is 0, 1 or 2; R<1> is -A-R<2>, -CO-A-R<2> or -SO2-A-R<2>; wherein R<2> is guanidine, amidine or amino, and A is an alkyl, alkenyl or alkynyl chain of 2 to 6 carbons; or R<1> is -(CH2)p-A'-R<2'> or -(CH2)p-CO-A'R<2'> where p is 0, 1 or 2, R<2'> is amidine and A' is an aza...

PURPOSE:To obtain a dental pulp-capping agent used for therapies of dental caries, especially for the repairing therapy of teeth, utilizing the biological reactions of bone-forming proteins, and having a dentine-regenerating ability on the therapies. CONSTITUTION:This dental pulp-capping agent enabling the formation of dentine contains a purified bone-forming protein as an active ingredient and, i...

PURPOSE:To obtain a pyridone carboxylic acid-containing preparation containing aspartame and a metal compound containing aluminum or magnesium as a constituting component, useful as an antibacterial agent, and reduced in bitter taste. CONSTITUTION:This pyridone carboxylic acid-containing preparation contains a pyridone carboxylic acid of formula I [R<1> is lower alkyl, lower alkenyl, cycloalkyl, a...

PURPOSE:To obtain a feline respiratory disease therapeutic agent exhibiting remarkable effects, even when administered through routes except veins, and capable of reducing the labor load of a person on the therapeutic duty and the economical load of an owner. CONSTITUTION:The characteristic of this feline respiratory organ disease therapeutic agent comprises containing as an active ingredient an i...

PURPOSE:To prepare a calcitonin gene-related peptide (CGRP) compound aqueous solution composition containing the CGRP compounds under specific conditions as an active ingredient and useful as a medicinal treatment injection excellent in heat and light stability. CONSTITUTION:The preparation of the CGRP compound aqueous solution compositions is to adjust the PH of a solution to 4-5 and the ion stre...

PURPOSE: To provide the water-soluble pharmacologically active peptide in a biodecomposable polyester having an excellent drug stability profile and stability. CONSTITUTION: This medicinal compsn. contains the peptide combined with embonic acid or ascorbic acid or its salt (excluding 1) ACTH combined with the embonic acid or ascorbic acid or its salt or 2) the LHRH active component combined with t...

PURPOSE: To provide an aq. antiacid suspension which has a good flow property, pouring property and suspension characteristics at the time of mixing with water and has perfect resuspendability under typical preservation conditions and a rehydratable magaldrate antiacid compsn. which may be formulated as a chewable tablet having a decreased gritty feel when ingested. CONSTITUTION: The antiacid comp...

PURPOSE:To obtain a pharmaceutical composition having improved peroral absorptivity and containing a 2'-deoxy-2'-methylidenecytidine compound useful as a carcinostatic agent by its remarkable degenerative action on solid tumor, etc. CONSTITUTION:This carcinostatic agent composition for peroral administration contains a 2'-deoxy-2'-methylidenecytidine compound of the formula (R is H or halogen; R<1...

PURPOSE:To prepare an oil-suspension eye lotion having excellent dispersibility of drug and high stability. CONSTITUTION:This oil-suspension eye lotion which contains a compound of formula I (R<1> to R<3> are lower alkyl) or its salt permissible as pharmaceuticals (preferably meropenem of formula II) as an active component is produced by compounding 12-hydroxystearic acid as a dispersing agent. Th...

PURPOSE: To provide a new modification type of refibrol, which can appropriately be crystallized and therefore causes no problem at the time of performing its large-scale industrial production and also, can be prescribed in the form of an agent having acceptable size, high stability and a high content of this type of refibrol. CONSTITUTION: This type of refibrol has a 132 to 138 deg.C or preferabl...

PURPOSE:To prepare an eye lotion capable of improving the aging stability of vitamin A compounds and decreasing the stimulation to the eye. CONSTITUTION:This eye lotion containing solubilized vitamin A compound is produced by compounding a vitamin A compound, a hydrogenated lecithin such as hydrogenated soybean lecithin and hydrogenated yolk lecithin and a nonionic surfactant such as polyoxyethyle...

An apparatus for supplying a web of material is provided that automatically changes the roll of material from an exhausted roll to a new full roll of material. The apparatus includes a plurality of spindles for supporting a plurality of rolls of material, the spindles being coupled to a rotatable carousel, a locking member for selectively preventing the rotation of the carousel is provided as well...

Dilatation balloon devices that employ a small diameter, torqueable metal tube for introduction of inflation fluid from distal end into a balloon have special features that enable introduction through very small passages. A distal core wire is shown forming part of a guide wire extending into the distal end of the tube . The core wire is fixed at the distal end of the tube, and has a proximal exte...

An apparatus for the thermal decomposition of a fluid toxic substance contained in a gas comprises a cylindrical main combustion chamber and a secondary combustion chamber arranged thereabove. An inlet opening leads into the main combustion chamber at an angle to introduce a stream of the gas containing the toxic substance into the main combustion chamber with an angular momentum, a burner is arra...

In the method, a gas/liquid mixture is sprayed in the form of a mist onto the surface of the object to be cooled. A jet of liquid is atomised by the nozzle orifice to form a spray mist with a particle size < 100 mu m and, after its emergence from the nozzle, is acted upon by gas jets at an angle ( alpha ) of between 0 and 90 DEG to the nozzle axis (x) for the purpose of acceleration and directio...

Novel compounds of the formula pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.

Novel compounds of the formula pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.