This invention relates to activated electrophilic ketone analogs of certain peptidase substrates which are useful in inhibiting serine-, carboxylic acid- and metallo- proteolytic senzymes, the inhibition of which will have useful physiological consequences in a variety of disease states.

An ultrasonic imaging probe includes a probe guide assembly, an ultrasonic transducer fixed to the distal end of the probe guide assembly, and electrical cabling housed within the probe guide assembly and operatively connected to the transducer for sending electrical pulse/signals to/from the transducer. The transducer is of a type which emits/receives ultrasonic waves along a path parallel to the...

A method and mechanism for shortening the execution time of certain macro-instructions by looking at both a present macro-instruction and a next macro-instruction. The invention includes two, interrelated aspects for accomplishing this. First, a first operation of a next macro-instruction is performed concurrently with a last operation of a current macro-instruction. Second, the next macro-instruc...

N-acyl-N,N min -dilysogangliosides, wherein the acyl groups are derived from unsubstituted aliphatic acids having from 1 to 11 carbon atoms, and N min -acyl-N,N min -dilysogangliosides and N,N min -di-acyl-N,N min -dilysogangliosides, in which the acyl groups are derived from unsubstituted aliphatic acids having from 1 to 24 carbon atoms (with the exception of certain acetyl and diacetyl derivativ...

Anthracycline derivatives which have cytostatic activity and correspond to the formula I in which the radicals have the following meaning: R<1> H or OH, R<2> H, OH or OMe, R<3> H, OH or COOMe, R<4> COMe, COCH2OH, CH(OH)Me, CH(OH)CH2OH or C1-C2-alkyl, R<5> H, OH, O-tetrahydropyranyl or O-acetyl, R<6> and R<7> C1-C4-alkyl and n = 1, 2 and/or 3, a process for the preparation ...

The use of adenosine derivatives in preparing pharmaceutical compositions possessing immunostimulant activity, comprising a pharmacologically acceptable carrier and an effective quantity of at least one of said adenosine derivatives of general formula (I): in which: R = C1-C18 linear or branched alkyl radical, or phenylalkylene radical in which the alkylene chain has 1-6 C atoms R1 = H, C...

A pin (3) is fitted in the bore of a bush (4) by a robot arm (1) which is fitted with a gripper for gripping the pin. The gripper (2) is attached to the arm by a coupling (6) in which the lower part (6'') has limited angular and lateral movement relative to the upper part (6') to compensate for any initial alignment error of the pin relative to the push (4). The lower part of the coupling has con...

The invention relates to silane derivatives of the formula I (I) their preparation by hydrosilylation of corresponding (meth)acrylamides and their use as silylating agents.

A car seat comprises a frame (1), which is preferably upholstered and which forms a sitting surface (2) and a back-rest (3). For secure positioning of objects (5), at least the sitting surface (2) is connected to a retaining device (4) which prevents objects (5) placed on the sitting surface from falling or slipping off, and the retaining device (4) has a retaining element (6), at least in the fro...

Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically c...

This invention provides a novel compound having the following formula: This compound is a useful intermediate for the preparation of N-glycolylneuraminic acid:

Erythromycin A derivatives with high antimicrobial activity are disclosed. 14-hydroxyerythromycin A and derivatives show superior in vitro antimicrobial activity compared to the parent compounds.

Erythromycin derivatives represented by the general formula wherein R<1> is a hydrogen atom or a methyl group, R<2> is a hydrogen atom or a hydroxy group, R<3> is a hydrogen atom, a lower alkanoyl group, an alkoxycarbonyl group or an alkylsuccinyl group, and salts thereof have antibacterial activity.

By using a flat knitting machine possessing a transfer lock capable of selecting and guiding the knitting needles (A-F, a-f) to the loop transfer track or loop receiving track within the same phase as at least one knitting lock capable of selecting and guiding the knitting needles to three positions of knit, tuck and welt, there is provided a method of knitting a thick fabric, which is less elasti...

A process is disclosed for improving the thermal stability of polyalpha-olefin lubricants by contacting the lubricant with an acidic catalyst for a time and at a temperature sufficient to achieve the skeletal isomerization of the molecular structure of the lubricant. The reaction is carried out preferably on unhydrogenated synthetic lubricants in contact with Lewis acid catalysts. Following the is...

Derivatives of antibiotics derived from the microorganism streptomyces lydicus subspecies tanzanius, referred to as antibiotics LL-E19020 alpha and beta (formula I), are produced by chemical reaction. The derivatives are also active antibiotics useful in the treatment of bacterial infections. t

The present invention relates to 2 min -fluoro substituted purine nucleosides and their use in medical therapy, particularly for the treatment of infectious diseases including influenza virus and respiratory syncytial virus infections, to methods for their preparation and to compositions containing them.

A stable memory circuit (1) is disclosed. The circuit (1) includes a pair of memory banks (2(a)) and (2(b)) each having eight arrays of eight VRAMs (3). Each VRAM (3) is dual-ported and includes a processor port connected to a processor bus (6) and a stable memory port connected to a stable memory bus (7). Accordingly, stable memory operations such as copying operations may be carried out on the s...

There are provided certain 13-alkyl-23-imino and 13-halo-23-imino-LL-F28249 compounds which are useful for controlling endo- and ectoparasites, insects, acarids and nematodes.