The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.

An apparatus for thermoforming plastic substrates (10) has a mould (52) corresponding to the shape of the thermoformed substrate and a vacuum source for generating a pressure difference with which the substrate can be pressed onto the mould. The substrate is heated on one side using a plurality of infrared radiators (36) which are in each case assigned to individual segments of the substrate (10)....

To form a plating coat on steel works, the works are held in a fluorine- or fluoride-containing gas atmosphere in a heated condition to thereby remove oxidized scales such as SiOx, MnOx and the like on the surface layer of the work and form a fluoride layer to prevent forming oxidized scale newly. The fluoride layer is easily eliminated by the action of flux added to a plating bath or by holding t...

A RF choke for use in shielded cable control lines between a RF receive and transmit coil and the control circuitry of a MRI system is disclosed. The RF choke is formed of conductive tubing in the shape of a coil, within which the control signal wires are housed. A capacitor is added in parallel with the conductive tubing coil to complete a resonance circuit acting as a choke to spurious RF curren...

A matching circuit for a RF coil on an MRI device is disclosed. The matching circuit includes a variable neutralizing inductance on the output side of the matching circuit ground breaker. All variable components are removed from the coil trace board, providing greater access to the tuning components during the MRI operation.

A method of controlling the hydration of a cementitious composition comprising the steps of: i) providing a cementitious composition containing an amount of a neutralized salt of an alpha-monohydroxy carboxylic acid effective to retard the cementitious composition, said carboxylic acid containing two or more carboxylic acid groups, and subsequently, ii) adding an additional amount of said neutrali...

Rapid-setting cementitious compositions comprise hydraulic cement and at least 4% by weight based on the weight of the cement of a water-soluble citrate, malate or citramalate or a mixture thereof. Alkali metal citrates, malates and citramalates are preferred. The compositions are especially useful as shotcrete.

A data processing system utilising two instruction sets. Both instruction sets control processing using full N-bit data pathways within a processor core 2. One instruction set is a 32-bit instruction set and the other is a 16-bit instruction set. Both instruction sets are permanently installed and have associated instruction decoding hardware 30, 36, 38.

A data processing system utilises multiple instruction sets. The program instruction words are supplied to a processor core via an instruction pipeline. As program instruction words of a second instruction set pass along the instruction pipeline, they are mapped to program instruction words of the first instruction set. The second instruction set has program instruction words of a smaller bit size...

An improved technique for processing Prolog objects is described. The first bit of the Prolog object word is used as a flag to indicate whether the object word is a type pointer or type descriptor. If the one-bit flag indicates that the object word is a type pointer, then the address is available for immediate processing without the unnecessary processing associated with the prior art. Significant...

The present invention relates to a stable mutant of Bacillus subtilis which can produce surfactin with high yields, a method of producing surfactin with the use of the strain and the use of the surfactin obtained for pharmaceutical, energy and environmental problems.

The invention relates to concrete and mortar for the wet-spraying process, whose setting time is extended and, for example, retarded to such an extent that it can be supplied from a ready-mixed concrete works to the building site and remains processable at the latter for up to 2 days, but can be caused at any time to stiffen immediately, to set and to harden quickly by addition of a setting accele...

Hydantoin derivatives of the general formula I in which n is 3 or 4, R<1> is alkyl or a radical of the formula with R' and R'' being hydrogen or alkyl and R<2> is hydrogen, -NH-CO-NH2 and optionally substituted alkyl, and processes for the preparation thereof and the use thereof for inhibiting platelet aggregation are described.

The individually controllable grippers (14) are partially opened as soon as the leading, open edge (30) of the folded printed product (24) in question reaches the region of the alignment device (28). The printed products (24) slide in the mouth (22) in the direction of the arrow (F) until the open edge (30) strikes an alignment cam (38). The alignment cams (38) are driven so as to rotate at a slig...

To improve the friction coefficients, in particular those of railway brake linings in the wet, it is proposed to impregnate the porous friction material with silicone oil. The water-repellent oil prevents the penetration of moisture into the lining and thus wet fading.

A tablet dispenser (1) for delivering individual tablets, in particular sweetner tablets, has essentially a container part (5) for said tablets and an outer part (7), relative to which the container part (5) can be displaced from the top downwards during the dispensing operation. A separating mechanism (3) is actuated by this movement, which mechanism allows in each case one tablet - in special ca...

A pressing or pelletizing device for compacting vegetable materials, in particular grass blades, is disclosed for use with a harvester. In order to reduce the pressing forces required for the pelletizing process, the pressing channels are heated up to a temperature above 100 degrees C. It has been demonstrated that by heating the pressing channels, local overheating of the device, which could othe...

An intraluminal imaging catheter system for viewing segments of vessels downstream of the catheter itself is provided. The catheter system incorporates an ultrasonic transducer pivotally mounted adjacent the catheter's distal end. A flexible drive means disposed within a flexible tubular member adapted for insertion into the vessel causes the transducer to pivot back and forth to scan a segment of...

Described is a method for determining the potency of bovine somatrotopin. The level of biologically active bovine somatotropin protein in the bovine somatotropin sample is measured by size exclusion HPLC employing as the stationary phase a hydrophilic porous polymer gel having an average particle diameter of about 5 mu m to about 15 mu m and as a mobile phase a buffered aqueous solution having a...

This invention provides for an acetabular cup and the manufacturing of an acetabular cup implant formed from a composite of polymer materials such that the articulating surface of the implant is 100% ultra high molecular weight poly ethylene (UHMWPE) and the bone engaging surface of the cup contains a significant amount of poly methyl methacrylate (PMMA). The cup would consist of at least two zone...