Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

PCT No. PCT/US95/06641 Sec. 371 Date Oct. 30, 1996 Sec. 102(e) Date Oct. 30, 1996 PCT Filed May 25, 1995 PCT Pub. No. WO95/35102 PCT Pub. Date Dec. 28, 1995A method for the preparation of 2'-modified nucleosides is provided. The method comprises a novel intramolecular nucleophilic displacement reaction. Included in the invention are novel 2'-modified pyrimidines and purines prepared according to t...

Compounds have the general formula (I) Z[-Y<1>-(A-Y<2>)m-X]n, in which the variables have the following meanings: Z stands for an n-valent aliphatic residue with 2 to 20 C atoms or for an n-valent three to seven-membered saturated or unsaturated carbocyclic or heterocyclic residue that may also be benzocyclised, or for an n-valent siloxane or cyclosiloxane residue with up to 10 Si atoms; Y<1>, Y<2...

Methods and compositions related to HIV are disclosed. Using the methods of the present invention, nucleoside analogs may be screened for the ability to be incorporated by reverse transcriptase of human immunodeficiency virus ("HIV RT") and cause incorrect base pairing. Progressive mutation of the virus by such nucleoside analogs renders it non-viable.

A method and apparatus for copyright protection for various recording media such as compact discs (CDs) uses a combination of symmetrical and asymmetrical data encryption to permit the player to handle either copy-protected or non-copy-protected media, in a manner that is extremely difficult to compromise. Coupled with the combination of encrypting methods, an Authenticating Signature is recorded ...

A trocar having an obturator with an obturator housing, a piercing tip and a rigid stem is disclosed. The piercing tip has a cutting edge surface and first and second spaced-apart legs generally parallel to each other extending away from the cutting edge surface. The stem is attached to the obturator housing at a first end of the obturator, and the legs of the piercing tip straddle the stem at an ...

Punching machine used advantageously, but not only, to prearrange substrates (20) for electrical micro-circuits, such as for example green-tape sheets, the machine having a supporting table movable on two axes (x, y) of the horizontal plane in cooperation with a punching stand (21), the punching stand (21) supporting a punching actuator movable on a vertical axis (z) and having at its lower end a ...

Portions (A1-D1) of multimedia program (presentation) are repetitively broadcast to receiving stations (122) with subsequent portions (C1-D1) being broadcast less frequently than preceding portions (A1-C1). Blocks (a-f) of at least one of the portions (A1) are broadcast in varying permutations from one repetition to a next repetition. Further, each portion is of a length which is proportional to a...

6-Alkoxy derivatives of Ara-G, and pharmaceutically acceptable esters thereof, are described as being useful in tumour therapy. Novel pharmaceutically acceptable esters, their preparation and pharmaceutical formulations containing them are also disclosed.

A conjugate of formula (1), wherein the moiety A-O- is the residue of any anthracycline of formula A-O-H bearing at least one primary or secondary hydroxyl group; a is an integer of from 1 to 30; W is a residue of formula (2), wherein B represents a C1-C6 alkylene group optionally hetero interrupted and m is 0 or 1; Z is a spacer group and T is a carrier moiety. The conjugates of formula (1) of th...

PCT No. PCT/GB91/01929 Sec. 371 Date Apr. 27, 1993 Sec. 102(e) Date Apr. 27, 1993 PCT Filed Nov. 4, 1991 PCT Pub. No. WO92/08193 PCT Pub. Date May 14, 1992A fault tolerant random access data storage system comprises a plurality of rows of memory chips 31 plus a first spare row of chips 32 and a second spare row of chips 33, each chip comprising an array of memory locations. A controller 25 address...

A pantyhose or the like garment having a novel waistband construction comprising an anchor portion (12) and an integrally knit wide band portion (14). The waistband (11) is substantially wider than conventional waistbands, the anchor portion (12) consisting of a narrow turned welt portion and a wide single ply band portion, each incorporating textured nylon and elastomer yarns.

PCT No. PCT/FI92/00077 Sec. 371 Date Jan. 6, 1994 Sec. 102(e) Date Jan. 6, 1994 PCT Filed Mar. 19, 1992 PCT Pub. No. WO92/16542 PCT Pub. Date Jan. 10, 1992.The invention relates to a novel crystalline anhydrous lactitol, a process for the preparation thereof, and the use thereof. The novel crystalline anhydrous lactitol belongs to the monoclinic crystal system and has the unit cell constants: (a)=...

PCT No. PCT/EP93/03236 Sec. 371 Date Jul. 26, 1994 Sec. 102(e) Date Jul. 26, 1994 PCT Filed Nov. 19, 1993 PCT Pub. No. WO94/12540 PCT Pub. Date Jun. 9, 1994.Compounds of formulae I and Ia R-Y-CO-R3-CO-O-A(I), R-Y-CO-R3-CO-O-CH2-A1(Ia), wherein R is a radically polymerisable hydrocarbon group, R3 is a direct bond, linear or branched C1-C22alkylene, C3-C8cycloalkylene or C6-C14arylene, A is the radi...

The invention concerns pale-coloured surfactants with an extremely low peroxide content, the surfactants being obtained by treating pastes of inorganic, non-ionic and/or amphoteric or zwitterionic surfactants with hydrogen peroxide in the presence of transition-metal compounds.

The present invention relates to methods for diagnosing vaginal disorders associated with various microorganisms that may be used in a medical practitioner's private office or in a more structured clinical environment, such as a hospital, a commercial clinical microbiology laboratory or the like. In addition, methods for simultaneously selectively detecting gram positive bacteria and at least one ...

PCT No. PCT/IB94/00199 Sec. 371 Date Dec. 22, 1995 Sec. 102(e) Date Dec. 22, 1995 PCT Filed Jul. 4, 1994 PCT Pub. No. WO95/02594 PCT Pub. Date Jan. 26, 1995The present invention relates to amide derivatives of formula (I) or (II) of 19-carboxy-19-deformyl 16-membered ring macrolide antibiotics rosaramicin, repromicin, tylosin, 5-O-mycaminosyltylonolide, 4-deoxy-O-mycaminosyltylonolide, desmycosin ...

Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

Derivát 1,5-dijod-|2S, R|-3-oxapentanu obecného vzorce I, kde znamená X alkylovou skupinu s 1 až 6 atomy uhlíku s přímým nebo s rozvětveným řetězcem nebo benzylovou skupinu, jakožto meziprodukt pro výrobu anthracyklinových glykosidů, které jsou účinnými látkami farmaceutických prostředků s nadějným účinkem proti nádorům. Způsob přípravy derivátu 1,5-dijod-|2S,R|-3-oxapentanu tak, že se oxiduje jod...

Zlepšená farmaceutická tableta obsahující nový polymorf dirithromycinu. Tableta může být povlečena jednou nebo několika vrstvami odolnými proti působení žaludeční kyseliny.ŕ; A tablet containing dirithromycin Form II.