A series of sulfated disaccharides having blocked anomeric centers have been shown to exhibit blood anticoagulant properties specific to inhibition of factor IXa, and can be used in vivo to inhibit clotting, extracorporeally, or in vitro to coat surfaces which come into contact with blood to inhibit the formation of clots thereon.

Disclosed are oligonucleotide analogs comprising oligonucleoside sequences having from 3 to about 200 bases and containing internucleoside linkages wherein amide linkages replace phosphodiester linkages that are the backbones of the natural oligonucleotides that make up RNA and DNA. Also disclosed are bifunctional nucleoside analogs, a process for preparing dimers and trimers therefrom, and a meth...

A copolymer of general formula (I), wherein unit A is a monomer of an electronically conductive polymer, unit B is a nucleotide, an oligonucleotide or an analogue thereof, x, y, z are integers of 1 or higher or y is 0, and 1 is a covalent bond, or a spacer arm. Methods for preparing polymer (I) and its use, in particular for nucleic acid synthesis, sequencing and hybridization, are also disclosed.

Disclosed are novel 5'-substituted nucleosides and oligonucleotide analog compounds prepared therefrom having from 2 to about 60 bases and having an internucleoside backbone containing one or more 3'-O-PO2H-O-5'-CR1R2- internucleoside linkages instead of the naturally occurring backbone of phosphodiester internucleoside linkages. The present invention also discloses a method of synthesizing oligon...

Oligonucleotides, which incorporate 7-deazanucleosides, are useful as antisense sequences to inhibit the function of RNA and DNA.

The present invention is directed to a non-radioactive targeting immunoreagent that comprises an immunoreactive group, one or more non-self-associating L-enantiomeric oligonucleotide sequences, and one or more linking groups, and to a radioactive targeting immunoreagent that comprises an L-enantiomeric oligonucleotide sequence that is complementary in sequence to and capable of hybridization with ...

Invention maintains duplicate files in safe places. A TOKEN Table (18) reflects the indices of successive segments of the file and the exclusive-or (XR) and Cyclic redundancy check (CRC) products of the characters in each segment. The XR and CRC products of segments in the updated file (10) are compared to the XR and CRC products in the TOKEN Table (18). On mismatch, the segment (window) for the u...

A media player and the clock which controls it are integrated into a single object. This integration may be achieved by the construct of inheritance between objects in an object oriented programming environment. A software class for player objects is established which inherits from a software class for clock objects. In this way, a player "is a" clock. This integration provides improved synchroniz...

This invention relates to a new electrochemiluminescent (ECL) label for oligonucleotides using phosphoramidite chemistry.

Polyamide-oligonucleotide derivs. of formula TÄ(NA-L)q (PA-L)r (NA-L)s (PA)tÜxT<1> (I) and their salts are new. In (I), q, r, s and t=0 or 1, provided that the sum of two or more adjacent q, r, s and t is at least 2; x=1-20; NA=a nucleic acid or a known nucleic acid deriv.; L=a covalent linker which is a direct bond or an organic gp. contg. at least one C, N, O or S atom; PA=a polyamide structure ...

Reagents useful in the preparation of 5 min -fluorescence-tagged oligonucleotides are disclosed. A class of oligonucleotides is also disclosed.

In a process for the production of moulded objects, in particular optical lenses, specifically contact lenses (CL), a starting material which can be crosslinked by exposure to suitable energy is introduced into a mould which is at least partially permeable to the energy concerned and has a mould cavity (15). The starting material is introduced in an at least partially still uncrosslinked state int...

The present invention provides a method for the purification of a 23-E isomer of a 23-imino derivative of a LL-F28249 compound having the structural formula I

PCT No. PCT/EP94/00145 Sec. 371 Date Sep. 18, 1995 Sec. 102(e) Date Sep. 18, 1995 PCT Filed Jan. 18, 1994 PCT Pub. No. WO94/17090 PCT Pub. Date Aug. 4, 1994The present invention relates to 2,6-diaminopurine- beta -D-ribofuranuronamide derivatives of the following formula (I). These compounds and their salts and solvates are useful as anti-inflammatory agents, particularly in the treatment of patie...

A row redundancy circuit for use in a semiconductor memory device having one memory cell array, and first and second main row decoders and first and second spare row decoders formed on both sides of the memory cell array includes a first fuse box for receiving addresses and, during the occurrence of a defective address out of the received addresses, cutting a fuse on an input path of the defective...

A composite material is disclosed in which an ultra-high molecular weight polyethylene top layer is backed with a non-woven fabric using a polyolefin resin as an adhesive layer disposed therebetween, and in which a portion of the non-woven fabric is impregnated with the polyolefin resin. The adhesive layer is formed by extruding a molten mass of the polyolefin resin through a die between the top a...

A packaging component (10) comprises a first, generally rectangular plastics element (11) and a second generally oval plastics element (12), each of such elements being inflatable and deflatable. A plastics coupling element (13) couples the first and second elements (11,12) and a valve (15) is used to permit air under pressure to be supplied to, or to be released from, the fist and second elements...

The invention provides method and apparatus for forming upper stops of a concealed type slide fastener. A concealed type slide fastener comprises a pair of fastener stringers each consisting of a fastener tape having a turn-up along one side thereof and fastener elements of thermoplastic resin secured to the turn-up. Portions of the elements are fused to form upper stops. In the method and apparat...

Method for attaching an insert (18), at least partly composed of thermoplastic material, in an at least partly hollow body also composed mainly of thermoplastic material, which is produced in a mould (1) either by melting the thermoplastic material in the mould (1) or adding it to the mould in a readymolten state and, after having spread the molten thermoplastic material in a layer (33) over the i...

Mechanically robust star couplers of polymer optical waveguides having low insertion losses and small fluctuations between the individual output fibers are obtained if polymer optical waveguides are arranged in parallel in the middle region of an apparatus and fused with one another under pressure and with the supply of heat. The optical cladding of the polymer optical waveguides has been previous...