Novel macrolides of formula (I): where Q is -CHO or -CH2OH and Y is hydroxyl or a mycarosyloxy group; and salts or esters thereof; can be prepared by the submerged aerobic cultivation of Streptomyces fradiae ATCC 31669 and are of value in the chemotherapy of microbiai infections in warm blooded animals and as intermediates in the preparation of other closely related macrolide antibiotics.

Compacts are provided in which one or more single crystal diamonds, having a largest dimension of at least one millimeter, are embedded in the polycrystalline matrix which may be made of diamond ; cubic boron nitride (CBN): and silicon and silicon carbide bonded diamond, CBN, or mixtures of diamond and CBN. The single crystal diamond is from 10-90 volume percent of the compact. The compacts (excep...

Novel 5'-deoxy-5-fluoropyrimidine nucleosides are potent anti-tumor agents. Preferred compounds are 5'-deoxy-5-fluorocytidine and 5'-deoxy-5-fluorouridine.

Disclosed are new antitumor compounds of the formula: I wherein R is hydrogen or trifluoroacetyl and the hydrochlorides thereof and a process for making same. Also disclosed is a novel intermediate (9-desacetyl-9-formyl-N-trifluoroacetyl-daunorubicin) used in the process.

Compounds of the formula wherein R1 is lower alkyl, lower alkoxycarbonyl-lower alkyl, phenyl, phenyl substituted by one or more lower alkyl or halogen, phenyl-lower alkyl optionally substituted in its side chain by lower alkyl or lower alkoxycarbonyl, thienylmethyl or thiazolyl, R2 is hydrogen or lower alkyl, or constitutes a 3-7-membered nitrogen-containing heterocyclic ring...

Compounds of the formula wherein R1 is optionally substituted phenyl, thienyl, 2-amino-4-thiazolyl or 2-chloroacetamido-4-thiazolyl; A is lower alkylene, lower alkenylene, or lower alkylene substituted by lower alkyl, amino, lower alkoxyimino or phenyl-Z-group wherein Z is a single bond or -S- or -SO2-, but when R1 is 2-amino-4-thiazolyl or 2-chloroacetamido-4-thiazolyl then A is lower...

New semi-synthetic antibiotic derivative are formed from N-methanesulfonic acid derivatives of 3-O-demethylistamycin B which are less toxic than the parent 3-O-demethylistamycin B and retain usefully high antibacterial activity of the parent antibiotic. The new derivatives are produced by a method of N-sulfomethylation where 3-O-demethylistamycin B is reacted with an aldehyde such as paraformaldeh...

A chair lift has a body housing a face plate electric motor (20) with a stator (40) and a shaft (35) secured to a face plate (42) which is driven by excitation of the stator. Spur gears (21) extend from the shaft to a driven sprocket (16) which engages a stairway track. The face plate is biased by a spring (48) into engagement with brake blocks (44) and excitation of the stator draws the face plat...

An aluminum co-precipitate of sucrose sulfate dihydroxyaluminum allantoinate of the general formula (R = SO3H, m = 1-3 and n = 7-12) is useful for treatment of peptic ulcers.

A process for the selective hydrogenation of dienes in pyrolysis gasoline which comprises catalytic hydrogenation of the pyrolysis gasoline in at least three consecutive reactors (R1, R2 and R3) in at least two of the said consecutive reactors recirculating part of the hydrocarbon mixture emerging from a reactor over that reactor, (5 and 7) no recirculation of the hydrocarbon mixture emerging from...

Novel erythromycin compounds of the formula wherein R1 is hydrogen or methyl, and a pharmaceutically acceptable salt thereof are disclosed. They exhibit excellent antibacterial activity against Gram-positive bacteria, acid stability and in vivo activity.

Plastics material mesh structures are made by providing a starting material having a pattern of primary holes or depressions and smaller secondary holes or depressions between the primary holes or depressions and stretching the plastics material to orientate the zones between adjacent holes or depressions to form orientated strands. A first stretch in a single direction produces intermediate struc...

This invention describes a process for preparing a high viscosity index low pour point lube base stock from an asphalt-free heavy hydrocarbon oil by first catalytically dewaxing the heavy oil with a catalyst comprising a zeolite having a Constraint Index of 1 to 12 and then hydrocracking or hydroconverting the dewaxed oil with a large pore zeolite catalyst such as dealuminized Y or ZSM-20 associat...

Hydrocarbon oils, particularly oils which have a high boiling temperature, are treated to remove organic sulphur compounds by subjecting a mixture of a hydrogenating gas, e.g. a gas containing at least 90% v/v hydrogen and is substantially free from carbon oxides, and partially vaporized oil to a hydrogenation reaction over a known hydrogenation catalyst and thereafter passing the resulting liquid...

The cured polyester or polyurethane adhesive bond seam joining two FRP (fiberglass reinforced plastic) parts, particularly in-mold coated FRP parts, is coated with a reactive polyepoxide resin-polyamide resinamine coating. After curing, sanding, sealing and painting, the seam area joining the parts did not exhibit any paint pops or sinks and the seam itself was invisible or nearly invisible.

An intraocular lens system including a negative-powered intraocular lens for use in combination with a positive-powered external lens system. The intraocular lens is preferably positioned in the posterior chamber of the eye and is configured so as to provide maximum separation between the intraocular lens and the external lens system, thereby achieving maximum magnification and field of view. Alte...

A pulse rate monitor for displaying the heart beat of a subject (12) while exercising comprises a pair of infrared emitters positioned on either side of a thin appendage of the body, such as the septum of the nose or the upper part of an ear (16). The emitter light paths are modulated by changes in the superficial blood volume in these areas, causing corresponding changes in the amount of reflecte...

Apparatus for stopping a sleeping person from snoring comprises a microphone 7 for receiving snoring sounds connected to a transmitter 15 which wirelessly transmits signals corresponding to the snoring sounds; and a mobile unit 3 comprising a receiver 17 which receives the signals emitted by the said transmitter and a voltage source 23, 25 controllable by the received signals and connected to two ...

An alcohol mixture suitable for combining with gasoline is produced by contacting synthesis gas at elevated temperature and pressure with an oxide complex catalyst containing copper, thorium, an alkali metal and at least one other specific element.