The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.

The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R, X,...

The invention relates to active fragments of the IL-18 binding protein, to pharmaceutical compositions comprising such active fragments, and to medical uses thereof.

Novel compounds and compositions containing ()-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making -3-hydroxybutyrate derivatives a...

This disclosure relates to compositions capable of use in the treatment of spinal cord injuries and related disorders of the central nervous system (CNS), and in particular, compositions including proteoglycan degrading molecules and compositions capable of blocking and/or over coming the activity of neuronal growth inhibitory molecules, as well as fusion proteins which includes a proteoglycan deg...

The present invention provides a method of treatment using human sequence antibodies against human CTLA-4. In particular, methods of treating cancer are provided.

The invention relates to compounds of formula (I) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.

The present invention provides isolated metal regulated polypeptides obtainable from a spp., and compositions including the polypeptides. The present invention also includes methods for using the compositions disclosed herein, including methods for treating in infection in a subject, for treating a condition caused by a spp., and for decreasing colonization of an animal.

A sustained release dosage form is comprising a pharmaceutically active agent and pharmaceutically acceptable salts thereof and adapted to release as an erodible solid over a prolonged period of time, wherein the dosage form provides an ascending rate of release of the pharmaceutically active agent for at least about 4 hours. The dosage form is able to deliver high doses of poorly soluble or slowl...

Insect control articles and methods of controlling insects comprising a cellulosic based substrate or matrix having a specified surface area impregnated and/or dosed with a vapour active pyrethroid in a carrier solvent, such that the vapour active pyrethroid is emanated into the environment at a rate of at least approximately 0.040 mg/h at a temperature of approximately 18-40 °C.

Accordingly, one object of the present invention are novel piperidine-substituted indoles- or heteroderivatives thereof of the formula (1) wherein R, R, R, A, B, D-E, X-W-V, Y, i, j, n and m are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositi...

[PROBLEMS] To provide an apparatus for carrying an article, a method of carrying an article into a transportation container by using the apparatus, and a method of carrying an article out from a transportation container by using the apparatus. The conveying apparatus is inexpensive and simple in structure and is capable of carrying various kinds of articles relative to a transportation container. ...

A combustible coil or stick for controlling mosquitoes is disclosed containing an insecticidally effective amount of bifenthrin.

The invention relates to novel active substance combinations comprising cyclic keto-enols or other insecticides and additional insecticides from the group of anthranilic acid amines. Said active substance combinations are very suitable for controlling animal pests such as insects and undesired mites.

The present invention provides transgenic plants with reduced levels of saturated fatty acids in the seed oil and methods of making these plants. The transgenic plants developed through this method contain reduced levels of saturated fatty acids in seed oil due to expression of a prokaryotic delta-9 desaturase enzyme (i.e. an enzyme that introduces cis double bonds at the delta-9 position of satur...

The present invention concerns a method for modifying the growth characteristics of plants by modulating expression in a plant of a nucleic acid sequence encoding a GRUBX protein and/or modulating activity and/or levels in a plant of a GRUBX protein. The present invention furthermore provides novel GRUBX proteins and nucleic acids encoding such proteins. The invention also relates to constructs co...

Novel compositions consisting of semi-interpenetrating network of cross-linked water soluble derivatives of basic polysaccharides and a non-cross-linked component, which is an anionic polysaccharide are provided. Methods for the production of such compositions are also disclosed. Preferably the basic polysaccharide is chitosan or a derivative thereof and the anionic polysaccharide is hyaluronic ac...

A breathing arrangement includes a patient interface (10), at least one inlet conduit (22), and a headgear assembly (31). The patient interface (10) includes a mouth covering assembly (14) including a cushion structured to sealingly engage around exterior of a patient's mouth in use, a nozzle assembly (16) including a pair of nozzles (17) structured to sealingly engage within nasal passages of a p...

The short form version of c-Maf transcription factor is up-regulated in steroid-treated and transforming growth factor beta2-treated trabecular meshwork cells, and is present at elevated levels in glaucomatous versus normal trabecular meshwork cells and in glaucomatous versus normal optic nerve head tissue. Expression of short form c-Maf transcription factor under these conditions indicates a caus...

Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.