Improved oral dosage formulations for acid-labile dideoxy purine nucleoside derivatives such as ddA, ddI, and ddG, have been developed by incorporating selected water-insoluble buffering systems in the formulation. These novel formulations provide reduced mass dosage units in the form of convenient, palatable chewable/ dispersible tablets or a dry powder sachet. The reduced mass requirement, neces...

The invention relates to compounds of formula (I): in which - Y represents - either a Cy-N or Cy-CH2-N group in which Cy represents an optionally substituted phenyl; - or a group in which .Ar represents an optionally substituted phenyl; .x is zero or one; .X represents a hydrogen, a hydroxyl, an alkoxy; an acyloxy; a carboxy; a carbalkoxy; a cyano; a -N(X1)2 group in w...

Synthesizing peptide mixts. comprises doing a 1st synthesis of peptide mixts., each made up of n amino acids or gps. of amino acids, by n synthetic steps of which the 1st steps comprises coupling to completion amino acids or gps. of amino acids individually to aliquots of solid-support resin, and the additional steps involve thoroughly mixing the aliquots of resin-coupled amino acids or gps. of am...

A method and apparatus for continuously extruding an elastomeric material 27 on the interior of a continuous tubular woven fabric 8 in a loom 1. The apparatus comprises motive means 3 for creating relevant movement between an extruder 2 and the woven fabric, sensing means for detecting stoppage of said loom or extruder and control means 4 responsive to said sensing means directing said motive mean...

NEW MATERIAL:2-(Dimethyloleylammonio)ethylphosphate of formula I (R is oleyl). USE:The compound can be applied as an emulsifier, solubilizing agent, dispersing agent, etc., to drugs, quasidrugs, cosmetics, pen inks, etc., and has excellent antibacterial property and surface activity. PREPARATION:Dimethyl(2-hydroxyethyl)oleylammonium halide of formula II (X is Cl, I, Br or F) is dissolved in benzen...

Ivermectin, an antiparasitic agent which is insoluble and unstable in water, is solubilized by the formation of colloidal particles, called micelles, with surface-active agents as solubilizers and stabilized by using water-miscible organic cosolvents and/or appropriate substrates in the aqueous formulation. The liquid formulations are suitable for use as parenteral or oral administration for the t...

In order to provide hinge fittings for seats with reclining backrests, particularly for motor vehicles, with an eccentric planetary gear mechanism whose rolling members are produced using an extrusion process and permit lockable reclining adjustments, and to do so in conjunction with functional reliability and safety with respect to their loadability - even in the event of a crash - accompanied at...

A lead-seal securing means of a bolt (13) which retains a covering (27) in the electric installation and can be released by turning exhibits a cap (20) which is seated on a head (15) of the bolt (13) and, by means of a locking element in the form of a flat tongue (21), which can be axially pushed on or in, engages in a rotationally fixed manner into an axial slot (19) of the head (15), on the one ...

The invention relates to a cable sleeve for the connection and branching of telecommunications cables, having a longitudinally divided sleeve tube and closure profiles bounding the longitudinal division, having sealing bodies which are sheathed by the sleeve tube for closing the sleeve tube at the ends and have cable bushings which can be matched to different cable diameters, and having circumfere...

Cable conduit bundle comprising a plurality of plastics tubes which are joined with the aid of moulded-on and deformable longitudinally extending connecting webs and can be unbundled to form a planar tube assembly having two outer tubes. A tube-bundle closure fin is moulded onto at least one of the outer tubes along a moulding-on line. Using this fin, the gap between the outer tubes in the tube bu...