An occlusion compound of 2-nitroxymethyl-6-chloropyridine with beta -cyclodextrin is disclosed herein as well as a process for preparing the occlusion compound thereof. The occlusion compound of the present invention has a molar ratio of 2-nitroxymethyl-6-chloropyridine to beta -cyclodextrin of between about 1:1 and about 3:1. The present occlusion compound is nonvolatile, thereby overcoming the ...

Examples of the compounds are D- and L-erythro-1-( beta -D- glucopyranosyloxy)-3-hydroxy-2-palmitoylamino-4-trans-octadecene, and the compounds promote wound healing and have a cell- and tissue-regenerating action and can be used for the treatment of wounds of any origin. They are prepared from ceramides of the formula (II)-D and/or (II)-L in good yield and in stereochemically pure form. The proce...

Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections. The fractions of hyaluronic acid are further useful as vehicles for opthalmic...

Vancomycin reacts with phosphoric acid to form a vancomycin diphosphate salt form that is highly crystalline when hydrated. An improved process for isolating vancomycin from an aqueous solution comprises formation of vancomycin diphosphate.

The known cpd., 4'-epidoxorubicine hydrochloride of formula (I), is made from N-trifluoroacetyl daunorubicin by (a) oxidising in 4'-position to obtain 4'-keto N-trifluoroacetyl daunorubicin, (b) stereo-specific redn. of the 4'-keto gp. and hydrolysis of the N-protecting gp. to obtain 4'-epidaunorubicin, (c) reacting with bromine to the 14'-bromo deriv., and (d) hydrolysis with aq. sodium formate s...

The present invention relates to anthracyclin derivatives of the formula I (I) in which R1 and R2 are identical or different and represent the sugar residue Roa (L-rhodosamine) of the formula or the sugar combination Roa-dF=CinB (dF=2-deoxy-L-fucose; CinB=L-cinerulose B) of the formula The invention furthermore relates to a process for the preparation of the above...

The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a teicoplanin-like compound to controlled strong acidic hydrolysis conditions.

The present invention is directed to a chemical process for preparing the antibiotic substance denominated antibiotic L 17054 and its pharmaceutically acceptable salts by selectively hydrolyzing teicoplanin or a factor or component thereof with a concentrated strong organic acid.

11 beta -Arylestradienes of general Formula I are disclosed (I) wherein R2 is a hydrogen atom, a methyl group, or an ethyl group, R3 is a hydrogen atom or an acyl group, R1 and A-B have various meanings, which possess antigestagen and antimineralocorticoid activity.

2-Fluoro-17 beta -estradiol is synthesized by mercurating a 17 beta -estradiol diacylate or dietherate at C-2, replacing the mercury group with fluorine and then cleaving the acyl or ether protecting groups.

Novel oxolinic-acid-amides of general formula I and their pharmaceutically acceptable salts are prepd. by reacting quinolin-3-carboxylic-acid-esters of general formula (II) iwth with a peptide of general formula (III). - In the formulae A, B, C and D stand for amino-acid rests opt. carrying the protective gp. usual inpeptide chemistry, Y means -OR1 or -NHR2, R1 is hydrogen or alkyl with 1-4 carbon...

1. Claims for the Contracting States : BE CH DE FR GB IT LI LU NL SE A medicament having a delayed action for the treatment of diabetes mellitus, comprising at least one insulin derivative of the formula I see diagramm : EP0137361,P16,F1 in which R**1 denotes H or H-Phe R**30 represents the radical of a neutral, genetically codable L-aminoacid whose OH group, where present, can be free or protect...

There is provided by this invention cell-targeting cytotoxic compositions comprising transferrin covalently coupled to vinca alkaloid.

The use as an activator for a chemical blowing agent, or as an accelerator or activator in the vulcanization of rubber, of a reaction product of urea and an oxide, carbonate or hydroxide of zinc, cadmium, calcium or lead, which reaction product may be optionally solvated, and certain such products per se.

Bitumen based composition with high heat sound corrosion resistance consists of (wt%): 20-30 Bitumen, from distillation of softening pt. 30-60 dc; 3-8 bodying gelling agent, of chlorinated rubber or polyolefins and organophilic bentonite. 32-50 fillers of aluminium hydro-silicate or aluminium-magnesium-silicate 1-8 tackifier, poly-cetyl-methacrylate and poly-iso-butylene, 9-43 mixed solvents iso-b...

The invention concerns a heat-sealing adhesive on the basis of copolyamides for the coating of fabrics, and especially of linings for outerwear. The invention consists of the fact that this heat-sealing adhesive contains from 0.3 to 15% by weight, preferably 0.7 to 12% by weight, of behenic acid. Thereby a substantially and unexpectedly increased adhesion strength of the adhesive is attained, so t...

The invention relates to a plastic deformable composition containing an adhesive and mineral grist. The adhesive is a mixture of 20-25% by weight of middle oil raffinate, 20-25% by weight of heavy oil raffinate, 40-52% by weight of microcrystalline paraffin, 1-4% by weight of macrocrystalline paraffin, 0.1-1.0% by weight of stearic acid and 0.01-2.0% by weight of coloring agent. The invention furt...

The compsns. used to prevent the formation of slippery road surfaces in freezing conditions contain mixts. of rock salt and granulated rhyolite tuff as roughening granular ingredient. The rhyolite tuff has a high content of zeolites, up to 50 wt.% The zeolites bind by ion exchange and ion adsorption, a large proportion of the salt soln. generated on the wet or icy road surface and considerably red...

Hydrocarbons are removed from water surfaces by compsns. contg. I 95.0-99.5 wt.% molten natural or synthetic wax having a m.p. of at least 40 deg.C or paraffins with 17-28 carbons are any mixt. of these, II 0.5-3.0 wt.% ground pumice or talc with an average particle size of 10-20 micrometer, and III opt. 0.5-2.0 wt.% calcium-hypochlorite with a particle size of 10-20 micrometer.

The drilling mud comprises (a) 30-50 kg/cu.m. bentonite, (b) 0.05-3 kg/cu.m. of acrylamide-alpha, beta-unsaturated aliphatic dicarboxylic acid copolymer, (c) 1-10 kg/cu.m. of a water deposition reducing agent and (d) a density increasing cpd. (b) pref. contains maleic or fumaric acid or their alkali or ammonium salts, or maleic anhydride, (c) is usually sodium polyacrylate or a cellulose glycolate...