Compounds of structure (I) in which, R<1> is hydrogen, C1-4alkyl, CHR<6>CONHR<7> or CHR<6>COOR<7> in which R<6> and R<7> are each hydrogen or C1-4alkyl; R<2> is hydrogen, C1-5alkyl or a residue R<2> of an amino acid R<2> CH(NH2)COOH; R<3> is hydrogen, C1-4alkyl, CONH2 or CO2R<8> in which R<8> is hydrogen or C1-4alkyl; and n is 2, 3 or 4, processes for their preparation, intermediates useful...

Novel 2-aminopyrimidinone derivatives of formula wherein -A<1>=A<2>-A<3>=A<4>- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N-, -N=CH-N=CH-, -CH=N-CH=N-; B is NR<8>, CH2, O, S, SO or SO2; R<8> is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl or Ar<2>-C1-6alkyl; R<1> is hydrogen, C1-10alkyl, C3-6cycloalkyl, Ar<1>, mono- and di(Ar<1>)-C...

New benzo[b][1,8]naphthyridine derivatives of general formula (I) in which R is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkoxy, alkylamino or protected alkylamino radical, Hal is F, Cl or Br if R' is hydrogen, or Hal and R' are F, and Alk is an alkyl radical, and their preparation. These new products can be used as intermediates for the preparation of biologically active p...

New benzo[b][1,8]naphthyridine derivatives of general formula (I) in which R1 is a hydrogen atom or an alkyl or hydroxyalkyl radical, R2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkoxy or alkylamino radical and R3 is alkyl, R4 and R5 are different and are hydrogen or alkyl, or R3 is H, alkyl or cycloalkyl and R4 and R5 are hydrogen, R6 is hydrogen or fluorine and n is eq...

1,8-Benzo (b) naphthyridine derivs. of formula (I), and their salts with metals and nitrogen bases, are new. R = H, alkyl, fluoroalkyl, 3-6C cycloalkyl, alkoxy, alkylamino, or it is a protecting gp., Hal = F, Cl, or Br and R' = H, or Hal = R' = F, 'alkyl' gps. may be opt. branched and contain 1-4C atoms.

The pyrrole derivatives of the formula in which R<1> to R<8>, R, X, Y and m have the meaning given in the description, are therapeutically active substances, in particular for use as substances having antiinflammatory, immunological, oncological, bronchopulmonary and cardiovascular activity or as active substances in the treatment of asthma or AIDS. They are prepared from corresponding fur...

The recovery of vitamin K-dependent proteins produced by transformed microorganisms can be effected from the cell culture medium utilizing the changes in the protein which occur in the presence of divalent cations. The present process uses divalent cations to alter the binding affinity of the proteins and thereby selectively elute the proteins away from contaminants in the culture medium using sta...

Amino acid derivatives of the formula I R<1>-Z-NR<2>-CHR<3>-CR<4>-(CHR<5>)a-CO-E-Q-Y I in which R<1> to R<5>, a, Z, E, Q and Y have the meanings indicated in Patent Claim 1, and the salts thereof, inhibit the activity of human plasma renin.

The invention is directed to C<6><3>-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicolplanins of the formula I wherein: A represents N[(C9-C12)aliphatic acyl]-beta-D-2-deoxy-2-aminoglucopyranosyl: B is hydrogen or a protecting group of the amine function; M represents alpha-D-mannopyranosyl; Y represents a di- or poly-amine group of the formula -NR-[(CH2)mNR<1>]n-X-[(CH2)k...

The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a teicoplanin-like compound to controlled strong acid hydrolysis in the presence of an organic aprotic solvent, and a purification thereof.

A process for the in situ blending of polymers comprising continuously contacting, under polymerization conditions, a mixture of ethylene and at least one alpha-olefin having at least 3 carbon atoms with a catalyst in at least two fluidized bed reactors connected in series, said catalyst comprising: (i) a complex consisting essentially of magnesium,titanium, a halogen, and an electron donor; (ii...

Alkyl methacrylate/alkyl acrylate polymers can be stabilised against degradation by ultraviolet light by the use of 0.5 to 2% non-polymerizable C1-C10 aliphatic alcohol and/or high boiling hydroxy compound.

The novel chain extenders based on chlorinated 4,4'-methylenebisanilines are used for p-phenylenemethylene diisocyanate prepolymers for cast polyurethane elastomers.

The present invention relates to polysiloxanes containing pendant sterically hindered phenol moieties. The compounds are represented by the general formula MDxD min yM.

Fe oxide pigment characteristics are modified by heating and maintaining the starting material at red heat in a neutral or reducing atmos. The glowing material is treated directly with and cooled down by water. - ()

Iron oxide pigment paste is obtd. from fly-ash of converter steel-mills. The enanuation from the stock is extracted by water, settled and filtered following addn. of coopulants. The filtration cake contains at least 80% iron oxide. This homogenised, its water content set, surfactant added and pigment particles dispersed. Pigment particles may be classified and sepd. in a hydrocyclone. - ()

A silicate based aq. exterior and interior paint compsn. of a controlled setting mechanism comprises (all %, 15-20 K-silicate soln. 5-20 aq. styrene-acrylate emulsion, 5-20 Ti02 pigment, 20-40 filler/borytes, dolomite, silica flour), 0.05-5.0 ethandolamine, 0.1-0.5 wetting agent (LOPAN TK) 0.15-0.5 thickness (NATROSOL H4BR) and 3-10 mica (PLASTORITOOO). - ()

A powdered wallpaper adhesive contains 50-96 % carboxy -methyl-cellulose, 2-35 % styrene-acrylonitrile copolymer, 1-4% sodium-tri-polyphosphate and 1-5% mould growth inhibitor or fungicide. - ()