Novel short peptides of up to about 20 amino acid residues are disclosed that bind to the SEC receptor. These novel peptides preferably are pentapeptides which are synthetic analogs of a pentapeptide domain in the carboxy-terminal fragment of alpha 1-antitrypsin (amino acids 370-374, Phe-Val-Phe-Leu-Met [SEQ ID NO:2]). A preferred binding peptide is Phe-Val-Ala-Leu-Met [SEQ ID NO:6].

A microprocesseur comprises a decoder for decoding an instruction supplied thereto and producing a decoded instruction, storage means for temporarily storing said decoded instruction, means for producing an execution ready signal when said decoded instruction stored in said storage means is brought into a ready state for execution, means responsive to said execution ready signal for reading out sa...

The invention provides human- or rat-derived neurotrophic peptides and derivatives thereof, precursor peptides thereof, genes encoding the same, transformants containing recombinant expression vectors bearing the genes, and compositions comprising as an effective ingredient these neurotrophic peptides or derivatives thereof. The neurotrophic peptide or its derivatives of the present invention have...

An improved process for the synthesis of 3'-fluoropyrimidine nucleosides of the general formula: by reacting a 5'-methanesulfonyl-2'-dideoxy-2,3' -anhydropyrimidine nucleoside at a concentration of up to 20% with hydrogen fluoride in the presence of a suitable aluminum reagent, recovering the 5'-methanesulfonyl-2',3'-dideoxy-3'-fluoropyrimidine nucleoside intermediate by direct crystallizat...

The invention relates to novel labelled modified oligonucleotides useful for gene therapy, a conjugate of a targeting moiety, such as an antibody and a modified oligonucleotide complementary to the labelled oligonucleotide, the combination of both being useful in therapy of viral infections, tumours and (auto) immunodiseases. Also disclosed are pharmaceutical formalations comprising the various co...

The present invention relates to 3 min -fluoro nucleoside analogues and their use in medical therapy, particularly for the treatment or prophylaxis of human immunodeficiency virus and hepatitis B virus infections, to methods for their preparation and to formulations containing them.

A method of linking nucleosides with a siloxane bridge comprising reacting a 3'-silylated-5'-protected nucleoside with an unprotected nucleoside is disclosed. The silylated and unprotected nucleosides may be either monomeric nucleosides or the terminal nucleosides of an oligonucleotide or oligonucleotide analog. A method of synthesizing an oligonucleotide analog having siloxane internucleoside lin...

Incubation of 13- beta -hydroxy avermectin aglycone with a species of B. subtilis results in the production of 13- beta ivermectin monoglucopyranoside as the major product and of 5- beta ivermectin monoglucopyranoside as the minor product.

A process is provided for the preparation of a compound of formula (I) or a salt thereof: wherein R<1> is hydrogen or a C1-4 alkyl, comprising reacting a compound of formula II: with an agent serving to introduce the alkynyl radical of formula -C IDENTICAL CR<1> (wherein R<1> is as described above) at the 5-position of the pyrimidine base, the reaction being carried out in the presen...

PURPOSE:To realize incidence of a trigger light beam to the upper external side of a semiconductor multilayered material without requiring an area by providing a trigger beam incidence window to an electrode or a semiconductor distributed reflector forming the semiconductor multilayered material attached on the main plane thereof. CONSTITUTION:A laser beam emitting and trigger beam incident window...

A row redundancy circuit for repairing a defective cell of a memory cell array in a semiconductor memory device comprising an address selector 300 for receiving two or more of address bit pairs, of an address bit pair group, designating the defective cell to selectively output one of the two or more address bit pairs, a fuse box 100 for storing the information of the remaining address bits of the ...

A column redundancy circuit for a semiconductor memory device, e.g., a DRAM, which includes a normal memory array comprised of a plurality of memory blocks each comprised of a matrix of rows and columns of memory cells, with at least two of the memory blocks sharing common columns, and with at least one of the columns being defective, in the sense of being connected to at least one memory cell whi...

3-Deoxy-derivatives of D-mannosamine of formula wherein R is -NH2 or a C2-C5 alkanoyl-NH- or CF3CONH- group; each of R1 and R2 independently is C1-C4 alkyl, or R1 is hydrogen, halogen, C1-C4 alkyl or C1-C4 alkoxy, and R2 is hydrogen or both of R1 and R2 are fluorine; and wherein, when R1 is methoxy and R2 is hydrogen then R is other than -NH2, and pharmaceutically acceptable salts thereof,...

PCT No. PCT/NL91/00009 Sec. 371 Date Jul. 16, 1992 Sec. 102(e) Date Jul. 16, 1992 PCT Filed Jan. 18, 1991 PCT Pub. No. WO91/10675 PCT Pub. Date Jul. 25, 1991.The invention relates to primers and a method of detecting human papilloma virus (HPV) genotypes by means of the Polymerase Chain Reaction (PCR). The invention provides such primers and such PCR conditions that in principle any genital HPV ge...

A conjugate of formula (1), wherein the moiety A-O- is the residue of any anthracycline of formula A-O-H bearing at least one primary or secondary hydroxyl group; a is an integer of from 1 to 30; W is a residue of formula (2), wherein B represents a C1-C6 alkylene group optionally hetero interrupted and m is 0 or 1; Z is a spacer group and T is a carrier moiety. The conjugates of formula (1) of th...

Apparatus for supporting a microphone C, connected by cord B to plug A, comprises triangular plate 1 screwable to a wall with its apex lowermost. In use a lead, not shown, passes via plate groove 12 and a rear recess (22, not shown) to socket 3 receiving plug A in forward facing recess 21. Cord B passes through a cord retainer (4, not shown) and gap 214 to be stored as windings on body 2 bounded b...

The probes of the invention are able to withstand higher temperatures, thereby allowing unmatched probes and mismatched probes to be washed off at higher hybridization stringency, thereby eliminating background readings and improving ease and accuracy of probe use.

A ligated technetium (III/II) complex is useful as a brain perfusion imaging agent. The complex has a technetium (III/II) center surrounded by six ligating moieties. The complex preferably has a reduction potential Tc(III) to Tc(II) which is less than about +0.6 volts vs Ag/AgCl (3M NaCl) and at least low enough to be oxidized in vivo after crossing the blood brain diffusion barrier. The technetiu...

A fused, redundancy selection circuit (20) is disclosed which is disabled by the absence of a chip select signal (CS). The circuit has the feature of avoiding the use of nodes with a floating potential and in this manner it provides an enhanced radiation hardened characteristics. The circuit is effectively disabled if no redundancy is required on a particular memory chip, by leaving fuses which ar...