Syringe has a barrel holding a piston on a plunger rod which has a resilient blocking member contacting the barrel inside surface to engage the sharp edge of a recess in the surface extending from the edge towards the needle end of the barrel. Engagement of the member with the edge prevents further retraction of the rod towards the barrel rear end. The rod is pref. slidably connected with the pist...

Compounds of formula (I) or pharmaceutically acceptable salts thereof; wherein R1 is a group -X-Y where X is a carbonyl group and Y is hydrogen, C1-8 alkyl, C2-8 alkenyl, or optionally substituted aryl or heteroaryl; R2 is hydroxy or C1-8 alkoxy; R3 is hydrogen or an amine protection group; and each R4 is hydrogen; their preparation, compositions containing them and their use as antifungal ...

Compounds of formula (I), or pharmaceutically acceptable salts thereof: wherein R1 is -CH2OH; R2 is hydrogen or C1-8 alkyl; R3 is hydrogen or an amine protection group; and each R4 is hydrogen; their preparation, compositions containing them and their use in the treatment of fungal infections are described.

Fermentation product A83543 (1), comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insectici...

7-O-glycosyl-rhodomycins which correspond to the following general formula I are described, in which the radicals have the following meaning: R<1> is a hydrogen atom or a hydroxyl group, R<2> is a hydrogen atom or a C1-C4-alkyl group, R<3> is a hydroxyl group, an acyl protective group or methoxycarbonyl group, R<4> is a hydrogen atom, an O-acyl protective group, an azido group, an am...

The compound of formula (I> has antiparasitic activity and is a useful intermediate in the preparation of other compounds having antibiotic activity.

Compounds having a polyhydroxylated hydrophilic moiety, a highly fluorinated moiety and a functional junction group linking said moieties together, wherein said hydrophilic moiety is derived from a polyol or an aminopolyol, and wherein said highly fluorinated moiety consists of a fluorocarbon group wherein at least 50 % of the atoms bonded to the carbon skeleton are fluorine atoms, the other atoms...

Compounds of the formula I wherein A is C1-8-alkylene, R1 is halogen, C1-4-alkyl or halo-(C1-4-alkyl), R2 is hydrogen, hydroxy or acyloxy, R3 is hydrogen or C1-4-alkyl, R4 is aryl or aryloxy and X is O or NH, and tautomers thereof are described. The compounds of formula I and their tautomers possess antiviral activity and can be used in the form of medicaments for the control and prev...

Novel hydrogen-phosphonodithioate compositions (I) are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides. The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be therapeutically useful as antiviral and anticancer agents and may have other therapeutic or diagnosti...

An integrated circuit memory is provided in which a repair circuit allows a redundant cell line to be substituted for a cell line which has proved defective. In the invention, access is had to the repair circuit by using the properties of the decoder of the memory. An instruction for decomposing a fuse is given, for all the repair circuits of the memory, through a single external terminal conected...

Griseolic acid derivatives of formula (I): (I) wherein A represents: have enzyme-inhibitory activity, especially against cAMP PDE and cGMP PDE. When formulated as compositions with appropriate carriers or diluents, they may be used for the treatment of a variety of organic disorders and show toxicities less than griseolic acid itself.

Stable salts of S-adenosyl-L-methionine with water-soluble polyanions, such as polyphosphates, polyvinylsulfonates -sulfates or -phosphates, polyacrylates, polystyrene sulfonates, are described. The salts according to the invention, prepared by precipitation from aqueous solutions of pH not exceeding 3.5, possess peculiar stability, solubility, nonhygroscopicity and are valuable for use as active ...

The present invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts particularly suitable for parenteral use, their production process, and pharmaceutical compositions containing them as active principles. Said salts correspond to the general formula: SAMe.n(CH2)m(SO3H)2(I) where n can vary from 1 to 2 and m can vary from 3 to 12. The process for producing said salts consists of ...

Circuit arrangement for telecommunications systems, in particular telephone switching systems, with storage devices in which the correctness of stored information portions is checked. Two parallel main memories for information and one secondary memory for parity bits are provided. If the information read out does not correspond owing to an error in one of the main memories or the write or read dev...

The device comprises a support plate (10) mounted on a first cylindrical body (13) and moved by a first system and a heating body (16) surrounding the said cylindrical body under the support plate and an insulating body (20) surrounding the heating body and integral therewith mounted on a second cylindrical body and moved coaxially with respect to the first cylindrical body by a second system, the...

The invention concerns a device for detecting variations in the physical state of the plastic material in a coupling piece used for welding pipes and incorporating a heating resistor, cavities which the softened material can enter and sensors for detecting the state of the material within the cavities. According to the invention, in order to obtain a weld of high quality, it is necessary for the d...

The present invention includes a method of enhancing the flavor of a mint flavored chewing gum by the addition of a minor amount of cocoa powder, as well as the chewing gum so produced. The amount of cocoa powder is selected so as to cause the flavor enhancement and so as to not impart a detectable chocolate flavor to the chewing gum. The level of cocoa powder added is between about 0.08 and 0.5 p...

A method and apparatus for winding yarn to produce a wound yarn package (40) having a variable density profile. The variable density profile in the wound yarn is produced by variably tensioning the yarn during the winding process by an electrical apparatus which is responsive to a programmed control signal to provide variable tension on the yarn. The density profile thus produced is preferably a p...

"DISPOSITIF POUR DETECTER AU COURS DU SOUDAGE DES VARIATIONS DANS L'ETAT PHYSIQUE DE LA MATIERE PLASTIQUE D'UNE PIECE DE RACCORDEMENT PREVUE POUR LA JONCTION DE TUBES" Au nom de : Service National dit : GAZ DE FRANCE L'invention concerne un dispositif pour détecter des variations dans l'état physique de la matière plastique d'une pièce de raccordement utilisée pour le soudage de tubes et comportan...

A wood preservative based on leaching-resistant, inorganic compounds for protection of wood and wood materials against wood-damaging insects and fungi, including wood-rot fungi, is disclosed. The wood preservative, which is fixed without chromium, contains as active ingredient in an aqueous solution which is stable on impregnation, (a) a Cu(II), Zn, Ni, Co, Fe, Mg and/or Mn salt of monofluorophosp...