A system is provided for performing injections in the ventricle of a patient. The system includes an injection catheter with a proximal and distal end. Importantly, a flexible array is mounted at the distal end of the injection catheter and is moveable between a protective configuration and a flared configuration. Also, a needle of variable length is mounted on the distal end of the injection cath...

A powered stapler (10) and method of operating same for stapling together two or more metal workpieces. The powered stapler (10) includes a main frame member (20) adapted to carry a strip of staples. The frame member has an anvil (2Oe) covered by a front nosepiece (48) at one end. A lower jaw member (22), having a lower cam slot (34), is pivotally attached to the main frame member. The lower jaw m...

There are disclosed bicyclic heterocyclic spiro compounds; pharmaceutical compositions comprising these compounds; and methods for the treatment in a mammal of diseases and conditions which are susceptible to modulation of the M1 muscarinic receptor, including Alzheimer's disease, insulin resistance syndrome and type 2 diabetes. Other embodiments are also disclosed.

A method of braiding a stent includes braiding a number of elongate filaments around a mandrel using tensioned braiding carriers without spooling the filaments to the tensioned braiding carriers to form a braided stent having atraumatic ends.

The invention relates to methods of treating Duchenne muscular dystrophy with flavonoids. The methods may include (a) providing a pharmaceutical composition comprising a therapeutically effective amount of flavonoid, and (b) administering the composition to a human patient, wherein the flavonoid comprises an isoflav-4-one with at least one of the carbons located at positions 8, 7, 6, 5, 2, 2', 3',...

Exemplary embodiments provide a method and system for shifting a graphical user interface around a touch screen display so that the menus and icons can be utilized from a plurality of user access positions. A first locating touch from the user may be used to determine the user's access position and the graphical user interface may be located on the display based on this locating touch. Embodiments...

Cette unité photovoltaïque (1A, 1B) comprend une plaque de support et un composant photovoltaïque (4A, 4B) disposé sur la plaque de support et comprenant un élément de raccordement d'entrée (6A, 6B) et un élément de raccordement de sortie (8A, 8B). L'unité comprend en outre au moins un premier circuit auxiliaire (14A, 14B), disposé sur la plaque de support et adapté pour conduire le courant électr...

Processes for coating a carrier with microparticles of a drug are described. For example, a coated carrier can be obtained in a one-stage process that entails evaporating a solvent from microdroplets of a solution containing an API to obtain dry microparticles, which are then coated on the carrier.

A system comprising a combination of orthopedic traction devices for limiting abduction of the arm and preventing impingement of the user's shoulder. The devices include a nighttime ipsilateral shoulder traction device with removable leg and wrist cuffs, an elastic connecting strap connecting the cuffs to apply impingement-reducing traction to the shoulder joint; and a daytime centrifugal exercise...

A passive inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler comprises a metallic piercing member with two piercing elements extending at least essentially in V-shape away from each other and being at least essentially flat. A contact member is arranged between the piercing elements to contact a lid of a bl...

The application claims a microfluidic device and a corresponding method suitable for immunofluorescence assays. The device comprises two planar components, one of which includes a groove on one surface. When the two surfaces are paired, the groove becomes a channel. The component without the groove is functionalised with nano-particles of metal oxide: this layer constitutes the bottom of the chann...

The invention relates to a portable, solar thermal device (1) for producing fresh water from wastewater or salt water. The device comprises a closed fluid circuit (2) made of pipe or hose elements connected to each other having a wastewater feed (3) and a fresh water drain (4), wherein the fluid circuit (2) comprises a tilted heating section (5) oriented substantially normal to the solar irradiati...

The invention relates to a syringe (1), comprising a syringe cylinder (5), a distal end (7) designed as a syringe cone, wherein said distal end (7) has a region (9) set back in a radial direction such that an edge (11) extending in the circumferential direction is formed, wherein said edge (11) has a chamfer, and comprising an attachment piece (13) having a clamping region (15), wherein holding fo...

An electric submersible motor is provided that includes a plurality of rotors and bearings mounted on a shaft, and a stator external to said rotors. A running clearance is located between an inner diameter of the stator and external diameter of the rotors, and includes a lubricating oil that includes a base hydrocarbon oil and a plurality of nanoparticles. Also provided is an improved lubricant oi...

A film sheet having a series of strips extending from an edge may have the film strips gathered and folded into a stacked array wherein the strips are in parallel abutment. The collected ends of the stacked strips are then suitable for receiving light for transmission into (and emission from) the body of the film sheet. A pair of frame members, when urged toward each other about the strips, may au...

This disclosure generally relates to methods useful for improving, for example, blood vessel density and/or blood vessel patency to a tissue by administration of a hedgehog pathway inhibitor. In certain embodiments, the hedgehog pathway inhibitor is administered with an agent to improve the delivery of the agent to the tissue. In certain embodiments, the tissue comprises tumor tissue.

Provided herein are mixtures, emulsions and other additives for use in manufacturing gypsum wallboard. The mixtures and emulsions may be wax-based emulsions or wax- free mixtures or emulsions, with wax-based emulsions including water; at least one wax, a dispersant which may include sulfur or a sulfur-containing group, and a particular wetting agent or surfactant. Mixtures may also be prepared inc...

Regimen for the treatment of rosacea include the application of an anti- redness composition to at least a portion of the cleansed area of skin afflicted with rosacea. The regimen may include the application of one or more of a polymetal complex, a composition containing metronidazole, and/or a protective composition. Kits containing components useful in performing such regimens are also described...

Provided is an ink for ballpoint pens which allows very light and smooth writing even under high writing pressure. An ink for ballpoint pens which comprises a coloring agent, a liquid medium, polyoxyethylene castor oil and/or polyoxyethylene hardened castor oil and derivatives of the same, and one member or a mixture of two or more members selected from among a monoalkyl ether phosphate, a polyoxy...

A surgical fastener applier having a handle and a fastener housing extending from the handle. The housing contains a plurality of surgical fasteners. The surgical fasteners have a base, and two legs extending away from the base, wherein the legs have distal end segments. The fastener has a first shape wherein the distal end segments bend towards each other so that they are adjacent and form the fa...