Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders...

Compounds of the formula (I) wherein R1 is each independently hydrogen or a group easily hydrolyzable under physiological conditions; R2 is -(CH2)n-cycloalkyl wherein cycloalkyl contains 3 to 5 carbon atoms and n is an integer from 0 to 4, heteroaryl-(lower-alkyl), (lower-alkoxy)-(lower-alkyl), aryloxy-(lower-alkyl), aralkyloxy-(lower-alkyl), (lower-alkylthio)-(lower-alkyl), arylthio-(lower-alkyl)...

The present invention relates to the preparation of novel vector systems which are generated by in-vitro recombination, using gene technology, of nucleic acids from foamy virus species and of exogenous nucleic acid, and are produced by suitable host cells or by recombinantly altered packaging cell lines. The recombinant preparation of particularly suitable packaging cell lines is likewise a consti...

Erythromycin derivs. of formula (I) and their acid addn. salts are new: wavy line indicates 10(R) or 10(S) methyl; R1, R2 = H or up to 24C opt. unsatd. hydrocarbyl (opt. interrupted by 1 or more heteroatoms and opt. carrying 1 or more functional gps.); or R1 + R2 = a heterocycle, opt. with 1 or more additional heteroatoms (N, O and/or S); or R1 + R2 = a gp. of formula (i); R1', R2' = H or up to 23...

The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) wherein R<1> may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R<2> may be hydrogen, a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, X represents sulfur, a sulfi...

The present invention provides the use of pramipexole as a neuroprotective agent.

A procedure for preparing 6-O-alkyl erythromycin compounds having the formula: wherein R1 is a loweralkyl group, R2 and R3 are independently hydrogen or a hydroxy-protecting group, except that R2 and R3 may not both be hydrogen simultaneously; Y is oxygen or a specifically substituted oxime; and Z is hydrogen, hydroxy or protected-hydroxy; by reaction of the compound wherein R1 is hydr...

A device for receiving and transporting objects has at least one pair of parallel chains or belts situated opposite each other and driven in synchrony, which define a space between each other for transporting the objects therethrough. Each chain has at least one gripper which is mounted so as to be pivotable thereon and faces a corresponding gripper on the other chain. Each gripper has an extensio...

The present invention provides various novel oligonucleotide analogs having one or more properties that make the subject compounds superior to conventional oligonucleotides for use in procedures employing oligonucleotides. The compounds of the invention are oligonucleotide analogs in which the furanose ring of a naturally occurring nucleic acid is replaced with an amino acid or a modified amino al...

The invention relates to 9-N-ethenyl derivatives of 9(S)-erythromycylamine, new semisynthetic antibiotics of the macrolide class of the general formula (I) wherein R<1> and R<2> are the same or different and represent nitryl, a carboxyl group of the formula COOR<3>, wherein R<3> represents a C1-C4 alkyl group, or a keto group of the formula COR<4>, wherein R<4> represents a C1-C4 alkyl grou...

A compound of formula 1, for which the substituents are defined herein. The compounds are used in the manufacture of pharmaceutical compositions for the treatment of a bacterial infection or a protozoa infection in a mammal, fish or bird.

Compounds of formula 1 and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, X1 and X2 are as defined herein. The compounds of formula 1 are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The disclosure also relates to pharmaceutical compositions containing the compounds...

A method of treating bacterial infection in non-human animals by administering a compound of formula (1) wherein: R1 is H, hydroxy or methoxy; R2 is hydroxy; R3 is alkyl, alkenyl, alkynyl, cyano, -CH2S(O)nR8 wherein n is an integer ranging from 0 to 2, -CH2OR8, -CH2N(OR9)R8, -CH2NR8R15, -(CH2)m(aryl), or -(CH2)m(heteroaryl), wherein m is an integer ranging from 0 to 4, and wherein the foregoing R3...

PURPOSE: A method and a circuit for repairing nonvolatile ferroelectric memory device are provided to change or add the redundancy by controlling the repair operation in response to the program encryption of the user. CONSTITUTION: A circuit for repairing nonvolatile ferroelectric memory device includes a row address buffer block(51), an address latch(52), a state diagram generation block(53), a p...

PROBLEM TO BE SOLVED: To obtain a metal wiring board, a semiconductor device and its manufacturing method in which a carrier sheet ensuring a highly reliable low resistance bump connection is provided using a low cost wiring pattern.

SOLUTION: The metal wiring board is manufactured by pasting a metal wiring (105) buried in the surface layer of an electric insulating substrate (104) and a me...

PROBLEM TO BE SOLVED: To provide a wiring board which is inexpensive and high in connection reliability, a semiconductor device, and a method of manufacturing the same.

SOLUTION: The wiring board is equipped with; a board provided with an electrode and covered with an insulating layer which is provided with a hole to expose the electrode; a wiring layer which is connected to the electrode a...

PROBLEM TO BE SOLVED: To solve a problem that it is necessary to strengthen the durability of an electronic watermark since various kinds of operation are applied to the contents data embedded with an electronic watermark.

SOLUTION: A multiplexer 20 produces L kinds of bit sequences by inserting different initial data to the head of watermark data X. A scrambler 22 respectively scrambles th...

PROBLEM TO BE SOLVED: To provide systems and methods for remotely scheduling tasks that are transmitted to a set-top box and implemented on the set-top box.

SOLUTION: A task service includes a website that provides program guide data to users. From the program guide data, a user selects a task. The website generates a notification that includes the task and certain identifiers, including a ...

PROBLEM TO BE SOLVED: To provide a cable television system in which a mobile terminal device can receive a cable television service even if it is located within the service area of any repeater, and to provide a repeater, a center device and a cable television service providing method.

SOLUTION: When a vehicle 5 mounted with a CATV mobile terminal 6 travels into the service areas of CATV st...

PROBLEM TO BE SOLVED: To provide a method and apparatus for discriminating a channel viewed on a television receiver, at high-speed.

SOLUTION: A reference tuner 32 uniquely reproduces an audio signal of a channel being a discrimination object and provides an output. An audio comparison section 31 discriminates the similarity of feature quantity of an audio signal outputted from a speaker ou...