The present invention is concerned with the compounds of formula I, wherein one or both of the acidic hydroxy groups of the phosphonic acid moiety may be etherified, m reprensents one or zero, R<1> is carboxy, esterified carboxy or amidated carboxy, wherein the five or six-membered heterocyclic ring may be additionally substituted on carbon and/or nitrogen, may have present a carbon-carbo...

There are disclosed antitumor active 1,2-diphenyl-ethylenediamine)-platinum(II)-complex of the general formula I wherein R7 is hydrogen or C1-C6-alkyl and R2 is either (1) a halogen atom and the groups R1, R3, R4, R5, and R6 are the same or different and are hydrogen, halogen, trihalomethyl, C1-C6-alkyl, hydrogen C1-C6-alkoxy, a C2-C6-alkanoyloxy or a halo or C1-C4-alkanesulfonyloxy s...

An antibiotic, TAN-588, produced by bacteria belonging to genus Empedobacter or Risobacter, p-nitrobenzyl- or benzhydryl ester derivatives thereof, N-deacetyl derivatives thereof, and salts thereof have an anti-bacterial effect on Gram-positive and Gram-negative bacteria, and can be used as agents for treating bacterial diseases of mammal, fowl, etc.

4-Demethoxy daunorubicin of formula (I) is made from optically-active 4-demethoxy daunomycinone, which is condensed in organic solvent in presence of silver trifluoromethanosulphonate, with a N,O-trifluoroacetyl-protected 1-chloro daunosamine, to obtain the N,O-protected alpha-anomeric glucoside. By elimination of the protective gps., first with methanol and then by mild alkaline hydrolysis, e.g. ...

The invention relates to the separation of corrinoids, more particularly to the separation of corrinoids by selective adsorption and/or selective elution on a polymeric absorbent having a large specific surface. The process according to the invention is equally suitable for the separation of incomplete corrinoids from complete corrinoids and various complete corrinoids, preferably vitamin B12 and ...

A novel steroid of the formula I wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or -S- and R is optionally substituted carbocyclic aryl or heterocyclic aryl, R2 is methyl or ethyl, R3 is selected from the group consisting of optionally substituted alkyl of 1 to 8 carbon at...

Novel glyco-cholic bile acid derivs. of general formula (1) (R representing alkyl groups of 1-4C atoms and m is 1,2,3 or 4) are prepared by the action of an acetylating derivative of a dicerbonic acid (111) on a cpd. of general formula (11).

Compounds of the formula in which R1 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, X represents -CH2-, -O-or -NH-, R2 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, R3, R4 and R5, independently of one another, denotes hydrogen or acyl-CO-R6, R6 being an alkyl r...

Compounds having activity in treating or preventing foot and mouth disease are disclosed. The compounds contain a sequence of the formula X-A-Y-B-Z in which A and B are amino acid residue sequences comprising sequences of the foot-and-mouth disease virus VP1 capsid protein serotypes, one of which contains from 18 to 24 amino acid residues and includes the amino acid residue sequence in positions ...

Compounds of the formula I are disclosed, in which: P is a D or L isomer of Arg, Lys, HArg, MeArg, MeLys or MeHArg; A is a D or L isomer of Arg, Lys, HArg, MeArg, MeLys or MeHArg; B is OH, NH2 or NHAlk; Z is Phe, Phe(4 min -Alk), Tyr(Alk), Ile or Tyr; X is a D or L isomer of Phe, Phe(4 min -Alk), Val, Nva, Leu, Ile, Pba, Nle, Cha, Abu, Met, Chg, Tyr or Tyr(Alk); Y is Val, Ile, Abu, Ala...

Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH, can be used to prepare solutions having prolonged insulin action. In the novel insulin derivatives, a basic amino acid has been substituted in the B27-position and/or a neutral amino acid has been inserted in the A4-, A17-, B13- and/or B21-position. Furthermore, the C-terminal carboxyl gr...

The present invention is directed to ester derivatives at the carboxylic function of the glycopeptidic antibiotic substance called antibiotic L 17046 with antimicrobial activity mainly against gram-positive bacteria.

The invention relates to a process for chemical sensitizing of silver halide photographic emulsions. For sensiblizing a sensitizer is used in form of an inclusion complex formed with cyclodextrin, substituted cyclodextrin or water soluble cyclodextrin polymer in an amount of 1 to 100 mu mole/mole silver halide. In the inclusion complex the ratio cyclodextrin/sensitizer may vary between 4:1 and 1...

Storage-stable polyisocyanurate-polyisocyanates, essentially devoid of polyisocyanate monomer and dimer over time, are conveniently prepared by catalytically cyclotrimerizing an aliphatic, cycloaliphatic or aromatic polyisocyanate in the presence of a catalytically effective amount of an aminosilyl catalyst, and terminating the cyclotrimerization reaction when predetermined desired amount of isocy...

Prepn. of farau based series by reacting formaldehyde carbamide and furfaryl alcohol and additives in the presence of water, occasionally phenol at pH:3-10. Some of the raw materials (mix A) are fed into the first and sometimes into the second unit of a series of interconnecting vessel ensuring undirectional flow. Another mixture of raw materials (mix B) is fed into vessel two and/or one occasion ...

The proposed plant is based on a maximum of five reaction units, connected in series by the reacting fluid pipes and each equipped with a refluxing cooler. Each reactor unit is located at a lower elevation than the unit upstream of it. The first, and/or the second, and/or the third reactor unit is connected by a feed pipe to a feeder. The last reactor unit connected to a product collector tank.

Non-shrinkage epoxy resin foams are formed by adding to 99.9-3 wt.% epoxy resin, 0.1-97wt.% physical blowing agent, as blowing agent contg. polystyrene beads. The mix is heated to 50-180 deg.C. - The foamed product shows no shrinkage, has limited thermal expansion, decreased density and in comparison with epoxy resins foamed by chemical means, exhibits improved physical mechanical properties.

Asphalt concrete is regenerated by comminution, and addn. of 0.1-1 wt.% of recovered motor oil as regenerating agent. - Pref. used motor oil has kinematic viscosity of 25-70 x 10 power minus 6 sq.m/sec. at 50 deg.C. Before and/or after comminution, the asphalt concrete is heated to 50-130 deg.C and the regenerant is worked into the asphalt concrete mixt. by thorough mixing.

Mixed solvents based coating agent, which contains solvent mixture swollen polymer powder or granules at 5-35% concn. calculated on dry wt. in addition to film forming polymer, pigment, and other formulating agents.